Cholangiocyte anion exchange and biliary bicarbonate excretion

Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors including hormones, innervation/neuropeptides, and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an importan...

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Autores: Banales, J.M. (Jesús M.)|||/items/0c1309ae-e4e4-4e85-b2f1-567a388889d5, Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71, Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
Tipo de recurso: artículo
Fecha de publicación:2006
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/20249
Acceso en línea:https://hdl.handle.net/10171/20249
Access Level:acceso abierto
Palabra clave:AE2 anion exchange
Bile salt-independent flow
Biliary bicarbonate excretion
Regulation of intracellular pH
Hydroionic fluxes in cholangiocytes
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spelling Cholangiocyte anion exchange and biliary bicarbonate excretionBanales, J.M. (Jesús M.)|||/items/0c1309ae-e4e4-4e85-b2f1-567a388889d5Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cfAE2 anion exchangeBile salt-independent flowBiliary bicarbonate excretionRegulation of intracellular pHHydroionic fluxes in cholangiocytesPrimary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors including hormones, innervation/neuropeptides, and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of the so-called bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms which involve chloride efflux through activation of Cl- channels, and further bicarbonate secretion via AE2/SLC4A2-mediated Cl-/HCO3- exchange. Glucagon and secretin are two relevant hormones which seem to act very similarly in their target cells (hepatocytes for the former and cholangiocytes for the latter). These hormones interact with their specific G protein-coupled receptors, causing increases in intracellular levels of cAMP and activation of cAMP-dependent Cl- and HCO3- secretory mechanisms. Both hepatocytes and cholangiocytes appear to have cAMP-responsive intracellular vesicles in which AE2/SLC4A2 colocalizes with cell specific Cl- channels (CFTR in cholangiocytes and not yet determined in hepatocytes) and aquaporins (AQP8 in hepatocytes and AQP1 in cholangiocytes). cAMP-induced coordinated trafficking of these vesicles to either canalicular or cholangiocyte lumenal membranes and further exocytosis results in increased osmotic forces and passive movement of water with net bicarbonate-rich hydrocholeresis.Baishideng Publishing Group Co. LimitedDadun. Depósito Académico Digital Universidad de Navarra20112011-12-1920062006-01-0120062006-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/20249reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/202492026-06-21T12:47:57Z
dc.title.none.fl_str_mv Cholangiocyte anion exchange and biliary bicarbonate excretion
title Cholangiocyte anion exchange and biliary bicarbonate excretion
spellingShingle Cholangiocyte anion exchange and biliary bicarbonate excretion
Banales, J.M. (Jesús M.)|||/items/0c1309ae-e4e4-4e85-b2f1-567a388889d5
AE2 anion exchange
Bile salt-independent flow
Biliary bicarbonate excretion
Regulation of intracellular pH
Hydroionic fluxes in cholangiocytes
title_short Cholangiocyte anion exchange and biliary bicarbonate excretion
title_full Cholangiocyte anion exchange and biliary bicarbonate excretion
title_fullStr Cholangiocyte anion exchange and biliary bicarbonate excretion
title_full_unstemmed Cholangiocyte anion exchange and biliary bicarbonate excretion
title_sort Cholangiocyte anion exchange and biliary bicarbonate excretion
dc.creator.none.fl_str_mv Banales, J.M. (Jesús M.)|||/items/0c1309ae-e4e4-4e85-b2f1-567a388889d5
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
author Banales, J.M. (Jesús M.)|||/items/0c1309ae-e4e4-4e85-b2f1-567a388889d5
author_facet Banales, J.M. (Jesús M.)|||/items/0c1309ae-e4e4-4e85-b2f1-567a388889d5
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
author_role author
author2 Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Medina, J.F. (Juan Francisco)|||/items/128a68d6-535b-4f01-b435-866451a921cf
author2_role author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv AE2 anion exchange
Bile salt-independent flow
Biliary bicarbonate excretion
Regulation of intracellular pH
Hydroionic fluxes in cholangiocytes
topic AE2 anion exchange
Bile salt-independent flow
Biliary bicarbonate excretion
Regulation of intracellular pH
Hydroionic fluxes in cholangiocytes
description Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors including hormones, innervation/neuropeptides, and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of the so-called bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms which involve chloride efflux through activation of Cl- channels, and further bicarbonate secretion via AE2/SLC4A2-mediated Cl-/HCO3- exchange. Glucagon and secretin are two relevant hormones which seem to act very similarly in their target cells (hepatocytes for the former and cholangiocytes for the latter). These hormones interact with their specific G protein-coupled receptors, causing increases in intracellular levels of cAMP and activation of cAMP-dependent Cl- and HCO3- secretory mechanisms. Both hepatocytes and cholangiocytes appear to have cAMP-responsive intracellular vesicles in which AE2/SLC4A2 colocalizes with cell specific Cl- channels (CFTR in cholangiocytes and not yet determined in hepatocytes) and aquaporins (AQP8 in hepatocytes and AQP1 in cholangiocytes). cAMP-induced coordinated trafficking of these vesicles to either canalicular or cholangiocyte lumenal membranes and further exocytosis results in increased osmotic forces and passive movement of water with net bicarbonate-rich hydrocholeresis.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01
2006
2006-01-01
2011
2011-12-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/20249
url https://hdl.handle.net/10171/20249
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group Co. Limited
publisher.none.fl_str_mv Baishideng Publishing Group Co. Limited
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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