Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity

© 2020 Jiménez-Saiz, Anipindi, Galipeau, Ellenbogen, Chaudhary, Koenig, Gordon, Walker, Mandur, Abed, Humbles, Chu, Erjefält, Ask, Verdú and Jordana.

Detalles Bibliográficos
Autores: Jiménez Saiz, Rodrigo, Anipindi, Varun C., Galipeau, Heather, Ellenbogen, Yosef, Chaudhary, Roopali, Koenig, Joshua F., Gordon, Melissa E., Walker, Tina D., Mandur, Talveer S., Abed, Soumeya, Humbles, Alison, Chu, Derek K., Erjefält, Jonas, Ask, Kjetil, Verdú, Elena F., Jordana, Manel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/229430
Acceso en línea:http://hdl.handle.net/10261/229430
Access Level:acceso abierto
Palabra clave:Eosinophils
Microbiota
Tissue remodeling
Small intestine
Allergy
Germfree
IgE
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spelling Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunityJiménez Saiz, RodrigoAnipindi, Varun C.Galipeau, HeatherEllenbogen, YosefChaudhary, RoopaliKoenig, Joshua F.Gordon, Melissa E.Walker, Tina D.Mandur, Talveer S.Abed, SoumeyaHumbles, AlisonChu, Derek K.Erjefält, JonasAsk, KjetilVerdú, Elena F.Jordana, ManelEosinophilsMicrobiotaTissue remodelingSmall intestineAllergyGermfreeIgE© 2020 Jiménez-Saiz, Anipindi, Galipeau, Ellenbogen, Chaudhary, Koenig, Gordon, Walker, Mandur, Abed, Humbles, Chu, Erjefält, Ask, Verdú and Jordana.Eosinophils have emerged as multifaceted cells that contribute to tissue homeostasis. However, the impact of the microbiota on their frequency and function at mucosal sites remains unclear. Here, we investigated the role of the microbiota in the regulation of enteric eosinophils. We found that small intestinal (SI) eosinophilia was significantly greater in germ-free (GF) mice compared to specific pathogen free (SPF) controls. This was associated with changes in the production of enteric signals that regulate eosinophil attraction and survival, and was fully reversed by complex colonization. Additionally, SI eosinophils of GF mice exhibited more cytoplasmic protrusions and less granule content than SPF controls. Lastly, we generated a novel strain of eosinophil-deficient GF mice. These mice displayed intestinal fibrosis and were less prone to allergic sensitization as compared to GF controls. Overall, our study demonstrates that commensal microbes regulate intestinal eosinophil frequency and function, which impacts tissue repair and allergic sensitization to food antigens. These data support a critical interplay between the commensal microbiota and intestinal eosinophils in shaping homeostatic, innate, and adaptive immune processes in health and disease.This work was supported by Food Allergy Canada, the Delaney family, the Zych family, the Walter and Maria Schroeder Foundation and AllerGen NCE. EV holds a Canada Research Chair and is funded by CIHR grant MOP# 142773.Frontiers MediaCanada Research ChairsCanadian Institutes of Health ResearchConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/229430reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3389/fimmu.2020.00155Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2294302026-05-22T06:33:51Z
dc.title.none.fl_str_mv Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
title Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
spellingShingle Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
Jiménez Saiz, Rodrigo
Eosinophils
Microbiota
Tissue remodeling
Small intestine
Allergy
Germfree
IgE
title_short Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
title_full Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
title_fullStr Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
title_full_unstemmed Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
title_sort Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity
dc.creator.none.fl_str_mv Jiménez Saiz, Rodrigo
Anipindi, Varun C.
Galipeau, Heather
Ellenbogen, Yosef
Chaudhary, Roopali
Koenig, Joshua F.
Gordon, Melissa E.
Walker, Tina D.
Mandur, Talveer S.
Abed, Soumeya
Humbles, Alison
Chu, Derek K.
Erjefält, Jonas
Ask, Kjetil
Verdú, Elena F.
Jordana, Manel
author Jiménez Saiz, Rodrigo
author_facet Jiménez Saiz, Rodrigo
Anipindi, Varun C.
Galipeau, Heather
Ellenbogen, Yosef
Chaudhary, Roopali
Koenig, Joshua F.
Gordon, Melissa E.
Walker, Tina D.
Mandur, Talveer S.
Abed, Soumeya
Humbles, Alison
Chu, Derek K.
Erjefält, Jonas
Ask, Kjetil
Verdú, Elena F.
Jordana, Manel
author_role author
author2 Anipindi, Varun C.
Galipeau, Heather
Ellenbogen, Yosef
Chaudhary, Roopali
Koenig, Joshua F.
Gordon, Melissa E.
Walker, Tina D.
Mandur, Talveer S.
Abed, Soumeya
Humbles, Alison
Chu, Derek K.
Erjefält, Jonas
Ask, Kjetil
Verdú, Elena F.
Jordana, Manel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Canada Research Chairs
Canadian Institutes of Health Research
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Eosinophils
Microbiota
Tissue remodeling
Small intestine
Allergy
Germfree
IgE
topic Eosinophils
Microbiota
Tissue remodeling
Small intestine
Allergy
Germfree
IgE
description © 2020 Jiménez-Saiz, Anipindi, Galipeau, Ellenbogen, Chaudhary, Koenig, Gordon, Walker, Mandur, Abed, Humbles, Chu, Erjefält, Ask, Verdú and Jordana.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/229430
url http://hdl.handle.net/10261/229430
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3389/fimmu.2020.00155
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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