The Role of Immune Cells in Oxi-Inflamm-Aging

Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade...

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Autores: Martínez de Toda Cabeza, Irene, Ceprián, Noemí, Díaz Del Cerro, Estefanía, Fuente del Rey, Mónica de la
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/4867
Acceso en línea:https://hdl.handle.net/20.500.14352/4867
Access Level:acceso abierto
Palabra clave:612.67
577.27
591.1
Aging
Immune cells
Oxidative stress
Inflammatory stress
Biological age
Inmunología
Fisiología animal (Biología)
2412 Inmunología
2401.13 Fisiología Animal
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oai_identifier_str oai:docta.ucm.es:20.500.14352/4867
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spelling The Role of Immune Cells in Oxi-Inflamm-AgingMartínez de Toda Cabeza, IreneCeprián, NoemíDíaz Del Cerro, EstefaníaFuente del Rey, Mónica de la612.67577.27591.1AgingImmune cellsOxidative stressInflammatory stressBiological ageInmunologíaFisiología animal (Biología)2412 Inmunología2401.13 Fisiología AnimalAging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.MDPIUniversidad Complutense de Madrid20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/4867reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/48672026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Role of Immune Cells in Oxi-Inflamm-Aging
title The Role of Immune Cells in Oxi-Inflamm-Aging
spellingShingle The Role of Immune Cells in Oxi-Inflamm-Aging
Martínez de Toda Cabeza, Irene
612.67
577.27
591.1
Aging
Immune cells
Oxidative stress
Inflammatory stress
Biological age
Inmunología
Fisiología animal (Biología)
2412 Inmunología
2401.13 Fisiología Animal
title_short The Role of Immune Cells in Oxi-Inflamm-Aging
title_full The Role of Immune Cells in Oxi-Inflamm-Aging
title_fullStr The Role of Immune Cells in Oxi-Inflamm-Aging
title_full_unstemmed The Role of Immune Cells in Oxi-Inflamm-Aging
title_sort The Role of Immune Cells in Oxi-Inflamm-Aging
dc.creator.none.fl_str_mv Martínez de Toda Cabeza, Irene
Ceprián, Noemí
Díaz Del Cerro, Estefanía
Fuente del Rey, Mónica de la
author Martínez de Toda Cabeza, Irene
author_facet Martínez de Toda Cabeza, Irene
Ceprián, Noemí
Díaz Del Cerro, Estefanía
Fuente del Rey, Mónica de la
author_role author
author2 Ceprián, Noemí
Díaz Del Cerro, Estefanía
Fuente del Rey, Mónica de la
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.67
577.27
591.1
Aging
Immune cells
Oxidative stress
Inflammatory stress
Biological age
Inmunología
Fisiología animal (Biología)
2412 Inmunología
2401.13 Fisiología Animal
topic 612.67
577.27
591.1
Aging
Immune cells
Oxidative stress
Inflammatory stress
Biological age
Inmunología
Fisiología animal (Biología)
2412 Inmunología
2401.13 Fisiología Animal
description Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/4867
url https://hdl.handle.net/20.500.14352/4867
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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