Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study

ObjectiveTo produce reference ranges and Z-scores for corpus callosal (CC) length in the fetus, based on transvaginal three-dimensional (3D) ultrasound imaging.MethodsThis was a cross-sectional multicenter retrospective study based on 3D volume dataset acquisitions of the fetal CC between the 15th a...

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Autores: Paladini, D, Parodi, S, Xie, H, Viñals, F, Haratz, K, Birnbaum, R, Azumendi, G, Pomar, L, Montaguti, E, Acharya, P, Volpe, P, Cruz, MP, Katrin, K, Chaoui, R, Pooh, R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p28610
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28610
Access Level:acceso abierto
Palabra clave:biometry
corpus callosum
fetus
neurosonography
three-dimensional ultrasound
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spelling Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional studyPaladini, DParodi, SXie, HViñals, FHaratz, KBirnbaum, RAzumendi, GPomar, LMontaguti, EAcharya, PVolpe, PCruz, MPKatrin, KChaoui, RPooh, Rbiometrycorpus callosumfetusneurosonographythree-dimensional ultrasoundObjectiveTo produce reference ranges and Z-scores for corpus callosal (CC) length in the fetus, based on transvaginal three-dimensional (3D) ultrasound imaging.MethodsThis was a cross-sectional multicenter retrospective study based on 3D volume dataset acquisitions of the fetal CC between the 15th and 37th weeks of gestation. Only volume datasets acquired transvaginally through the anterior fontanelle were selected. After plane alignment on multiplanar imaging, the length of the CC was measured edge-to-edge on magnified images. Intra- and interobserver variability were assessed and the related intraclass correlation coefficients (ICC) calculated. Biometric charts to assess the reference values for fetal CC were obtained using the method proposed by Altman in 1993.ResultsThe 13 participating centers provided valid data for 2131 patients. Excellent agreement was observed for both intra- and interobserver analysis, with an ICC range of 0.98-1.00. A quadratic model was used for construction of the reference charts, modified with the insertion of cubic spline coefficients with a single knot at 18 gestational weeks, to recover an apparent lack of fit at lower gestational ages. Centile reference values and the corresponding Z-scores were produced for CC length between 15 and 37 gestational weeks.ConclusionsThis multicenter study presents growth charts for the fetal CC, addressing the critical methodological weaknesses of several previous studies. An even distribution of cases across all gestational weeks, robust statistical methodology and a standardized, high-resolution transvaginal neurosonographic technique represent key factors supporting the reliability of the biometric curves presented here. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.WILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28610ULTRASOUND IN OBSTETRICS & GYNECOLOGYISSN: 09607692ISSNe: 14690705reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p286102026-05-27T12:37:41Z
dc.title.none.fl_str_mv Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
title Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
spellingShingle Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
Paladini, D
biometry
corpus callosum
fetus
neurosonography
three-dimensional ultrasound
title_short Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
title_full Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
title_fullStr Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
title_full_unstemmed Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
title_sort Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
dc.creator.none.fl_str_mv Paladini, D
Parodi, S
Xie, H
Viñals, F
Haratz, K
Birnbaum, R
Azumendi, G
Pomar, L
Montaguti, E
Acharya, P
Volpe, P
Cruz, MP
Katrin, K
Chaoui, R
Pooh, R
author Paladini, D
author_facet Paladini, D
Parodi, S
Xie, H
Viñals, F
Haratz, K
Birnbaum, R
Azumendi, G
Pomar, L
Montaguti, E
Acharya, P
Volpe, P
Cruz, MP
Katrin, K
Chaoui, R
Pooh, R
author_role author
author2 Parodi, S
Xie, H
Viñals, F
Haratz, K
Birnbaum, R
Azumendi, G
Pomar, L
Montaguti, E
Acharya, P
Volpe, P
Cruz, MP
Katrin, K
Chaoui, R
Pooh, R
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv biometry
corpus callosum
fetus
neurosonography
three-dimensional ultrasound
topic biometry
corpus callosum
fetus
neurosonography
three-dimensional ultrasound
description ObjectiveTo produce reference ranges and Z-scores for corpus callosal (CC) length in the fetus, based on transvaginal three-dimensional (3D) ultrasound imaging.MethodsThis was a cross-sectional multicenter retrospective study based on 3D volume dataset acquisitions of the fetal CC between the 15th and 37th weeks of gestation. Only volume datasets acquired transvaginally through the anterior fontanelle were selected. After plane alignment on multiplanar imaging, the length of the CC was measured edge-to-edge on magnified images. Intra- and interobserver variability were assessed and the related intraclass correlation coefficients (ICC) calculated. Biometric charts to assess the reference values for fetal CC were obtained using the method proposed by Altman in 1993.ResultsThe 13 participating centers provided valid data for 2131 patients. Excellent agreement was observed for both intra- and interobserver analysis, with an ICC range of 0.98-1.00. A quadratic model was used for construction of the reference charts, modified with the insertion of cubic spline coefficients with a single knot at 18 gestational weeks, to recover an apparent lack of fit at lower gestational ages. Centile reference values and the corresponding Z-scores were produced for CC length between 15 and 37 gestational weeks.ConclusionsThis multicenter study presents growth charts for the fetal CC, addressing the critical methodological weaknesses of several previous studies. An even distribution of cases across all gestational weeks, robust statistical methodology and a standardized, high-resolution transvaginal neurosonographic technique represent key factors supporting the reliability of the biometric curves presented here. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28610
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28610
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv ULTRASOUND IN OBSTETRICS & GYNECOLOGY
ISSN: 09607692
ISSNe: 14690705
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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