Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism

The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse...

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Autores: Antolín Llovera, Meritxell, Leivar Rico, Pablo, Arró i Plans, Montserrat, Ferrer i Prats, Albert, Boronat i Margosa, Albert, Campos Martínez, Narciso
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2011
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/51383
Acceso en línea:https://hdl.handle.net/2445/51383
Access Level:acceso abierto
Palabra clave:Genètica vegetal
Proteïnes vegetals
Metabolisme de les plantes
Biosíntesi
Isoprenoides
Plant genetics
Plant proteins
Plant metabolism
Biosynthesis
Isopentenoids
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spelling Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolismAntolín Llovera, MeritxellLeivar Rico, PabloArró i Plans, MontserratFerrer i Prats, AlbertBoronat i Margosa, AlbertCampos Martínez, NarcisoGenètica vegetalProteïnes vegetalsMetabolisme de les plantesBiosíntesiIsoprenoidesPlant geneticsPlant proteinsPlant metabolismBiosynthesisIsopentenoidsThe enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.Landes Bioscience2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/51383Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.4161/psb.6.8.16363Plant Signaling and Behavior, 2011, vol. 6, num. 8, p. 1127 -1131http://dx.doi.org/10.4161/psb.6.8.16363(c) Landes Bioscience , 2011info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/513832026-05-27T06:46:51Z
dc.title.none.fl_str_mv Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
title Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
spellingShingle Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
Antolín Llovera, Meritxell
Genètica vegetal
Proteïnes vegetals
Metabolisme de les plantes
Biosíntesi
Isoprenoides
Plant genetics
Plant proteins
Plant metabolism
Biosynthesis
Isopentenoids
title_short Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
title_full Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
title_fullStr Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
title_full_unstemmed Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
title_sort Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
dc.creator.none.fl_str_mv Antolín Llovera, Meritxell
Leivar Rico, Pablo
Arró i Plans, Montserrat
Ferrer i Prats, Albert
Boronat i Margosa, Albert
Campos Martínez, Narciso
author Antolín Llovera, Meritxell
author_facet Antolín Llovera, Meritxell
Leivar Rico, Pablo
Arró i Plans, Montserrat
Ferrer i Prats, Albert
Boronat i Margosa, Albert
Campos Martínez, Narciso
author_role author
author2 Leivar Rico, Pablo
Arró i Plans, Montserrat
Ferrer i Prats, Albert
Boronat i Margosa, Albert
Campos Martínez, Narciso
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Genètica vegetal
Proteïnes vegetals
Metabolisme de les plantes
Biosíntesi
Isoprenoides
Plant genetics
Plant proteins
Plant metabolism
Biosynthesis
Isopentenoids
topic Genètica vegetal
Proteïnes vegetals
Metabolisme de les plantes
Biosíntesi
Isoprenoides
Plant genetics
Plant proteins
Plant metabolism
Biosynthesis
Isopentenoids
description The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/51383
url https://hdl.handle.net/2445/51383
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.4161/psb.6.8.16363
Plant Signaling and Behavior, 2011, vol. 6, num. 8, p. 1127 -1131
http://dx.doi.org/10.4161/psb.6.8.16363
dc.rights.none.fl_str_mv (c) Landes Bioscience , 2011
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Landes Bioscience , 2011
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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