Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis

Cirrhosis is associated with changes in gut microbiome composition. Although acute-on-chronic liver failure (ACLF) is the most severe clinical stage of cirrhosis, there is lack of information about gut microbiome alterations in ACLF using quantitative metagenomics. We investigated the gut microbiome...

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Detalles Bibliográficos
Autores: Solé, Cristina, Guilly, Susie, Da Silva, Kevin, Llopis, Marta, Le-Chatelier, Emmanuelle, Huelin Álvarez, Patricia, Carol, Marta, Moreira, Rebeca, Fabrellas, Núria, De Prada, Gloria, Napoleone, Laura, Graupera, Isabel, Pose, Elisa, Juanola, Adrià, Borruel, Natalia, Berland, Magali, Toapanta, David, Casellas, Francesc, Guarner, Francisco, Doré, Jöel, Solà, Elsa, Ehrlich, Stanislav Dusko, Ginès, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/469813
Acceso en línea:https://doi.org/10.1053/j.gastro.2020.08.054
https://hdl.handle.net/10459.1/469813
Access Level:acceso abierto
Palabra clave:Chronic Liver Diseases
Gut-Liver Axis
Infections
Liver Failure
Descripción
Sumario:Cirrhosis is associated with changes in gut microbiome composition. Although acute-on-chronic liver failure (ACLF) is the most severe clinical stage of cirrhosis, there is lack of information about gut microbiome alterations in ACLF using quantitative metagenomics. We investigated the gut microbiome in patients with cirrhosis encompassing the whole spectrum of disease (compensated, acutely decompensated without ACLF, and ACLF). A group of healthy subjects was used as control subjects.

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