Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis

Background: The purpose of this work was to determine the influence of myocardial wringing on ventricular function in patients with cardiac amyloidosis (CA). Methods: Fifteen healthy volunteers (group 1) and 34 patients with CA (17 with left ventricular ejection fractions [LVEFs] >= 53% [group 2]...

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Autores: Mora V, Roldán I, Bertolín J, Faga V, Pérez-Gil MDM, Saad A, Serrats R, Callizo R, Arbucci R, Lowenstein J
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p9289
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/9289
Access Level:acceso abierto
Palavra-chave:Cardiac amyloidosis
Myocardial wringing
Myocardial strain
Ventricular torsion
Ventricular function
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spelling Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac AmyloidosisMora VRoldán IBertolín JFaga VPérez-Gil MDMSaad ASerrats RCallizo RArbucci RLowenstein JCardiac amyloidosisMyocardial wringingMyocardial strainVentricular torsionVentricular functionBackground: The purpose of this work was to determine the influence of myocardial wringing on ventricular function in patients with cardiac amyloidosis (CA). Methods: Fifteen healthy volunteers (group 1) and 34 patients with CA (17 with left ventricular ejection fractions [LVEFs] >= 53% [group 2] and 17 with LVEFs < 53% [group 3]) were evaluated using two-dimensional speckletracking echocardiography. A control group of mass-matched patients (n = 20) with left ventricular (LV) hypertrophy and LVEFs >= 53% was also included. Longitudinal strain (LS), circumferential strain, and LV twist and torsion were calculated. Deformation index (DefI), a new parameter of wringing, calculated as twist/LS, that takes into account actions that occur simultaneously during LV systole (i.e., longitudinal shortening and twist), was evaluated. Torsional and wringing parameters were calculated according to LVEF. Results: Lower global values of LS and circumferential strain were observed among patients with CA (LS: group 1, -20.6 6 2.5%; group 2, -11.6 6 4.1%; group 3, -9.0 +/- 3.1%; circumferential strain: group 1, -22.7 +/- 4.9%; group 2, -14.4 +/- 8.0%; group 3, -13.6 +/- 3.8%; P <.001 for both). Torsion did not vary between group 2 and group 1 (2.5 +/- 1.1-/cm vs 2.7 6 0.8-/cm, P = NS). In contrast, DefI was greater in group 2 than in group 1 (-1.8 6 0.8 degrees/% vs -1.0 6 0.3 degrees/%, P <.01). Torsion and DefI were lower in group 3 (1.2 6 0.7 degrees/cm and -1.1 6 0.6-/%, respectively, P <.001 for both) than in group 2. DefI was similar in patients with LV hypertrophy (-1.7 6 0.6 degrees/%, P = NS) and group 2. Conclusions: In patients with CA, preservation of LVEF depends on greater ventricular wringing. DefI, a parameter that integrates the twist and the simultaneous longitudinal shortening of the left ventricle, is a more accurate indicator of the efficacy of this mechanism.MOSBY-ELSEVIER2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/9289JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHYISSN: 08947317ISSNe: 10976795reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p92892026-06-11T12:45:17Z
dc.title.none.fl_str_mv Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
title Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
spellingShingle Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
Mora V
Cardiac amyloidosis
Myocardial wringing
Myocardial strain
Ventricular torsion
Ventricular function
title_short Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
title_full Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
title_fullStr Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
title_full_unstemmed Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
title_sort Influence of Ventricular Wringing on the Preservation of Left Ventricular Ejection Fraction in Cardiac Amyloidosis
dc.creator.none.fl_str_mv Mora V
Roldán I
Bertolín J
Faga V
Pérez-Gil MDM
Saad A
Serrats R
Callizo R
Arbucci R
Lowenstein J
author Mora V
author_facet Mora V
Roldán I
Bertolín J
Faga V
Pérez-Gil MDM
Saad A
Serrats R
Callizo R
Arbucci R
Lowenstein J
author_role author
author2 Roldán I
Bertolín J
Faga V
Pérez-Gil MDM
Saad A
Serrats R
Callizo R
Arbucci R
Lowenstein J
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cardiac amyloidosis
Myocardial wringing
Myocardial strain
Ventricular torsion
Ventricular function
topic Cardiac amyloidosis
Myocardial wringing
Myocardial strain
Ventricular torsion
Ventricular function
description Background: The purpose of this work was to determine the influence of myocardial wringing on ventricular function in patients with cardiac amyloidosis (CA). Methods: Fifteen healthy volunteers (group 1) and 34 patients with CA (17 with left ventricular ejection fractions [LVEFs] >= 53% [group 2] and 17 with LVEFs < 53% [group 3]) were evaluated using two-dimensional speckletracking echocardiography. A control group of mass-matched patients (n = 20) with left ventricular (LV) hypertrophy and LVEFs >= 53% was also included. Longitudinal strain (LS), circumferential strain, and LV twist and torsion were calculated. Deformation index (DefI), a new parameter of wringing, calculated as twist/LS, that takes into account actions that occur simultaneously during LV systole (i.e., longitudinal shortening and twist), was evaluated. Torsional and wringing parameters were calculated according to LVEF. Results: Lower global values of LS and circumferential strain were observed among patients with CA (LS: group 1, -20.6 6 2.5%; group 2, -11.6 6 4.1%; group 3, -9.0 +/- 3.1%; circumferential strain: group 1, -22.7 +/- 4.9%; group 2, -14.4 +/- 8.0%; group 3, -13.6 +/- 3.8%; P <.001 for both). Torsion did not vary between group 2 and group 1 (2.5 +/- 1.1-/cm vs 2.7 6 0.8-/cm, P = NS). In contrast, DefI was greater in group 2 than in group 1 (-1.8 6 0.8 degrees/% vs -1.0 6 0.3 degrees/%, P <.01). Torsion and DefI were lower in group 3 (1.2 6 0.7 degrees/cm and -1.1 6 0.6-/%, respectively, P <.001 for both) than in group 2. DefI was similar in patients with LV hypertrophy (-1.7 6 0.6 degrees/%, P = NS) and group 2. Conclusions: In patients with CA, preservation of LVEF depends on greater ventricular wringing. DefI, a parameter that integrates the twist and the simultaneous longitudinal shortening of the left ventricle, is a more accurate indicator of the efficacy of this mechanism.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/9289
url https://fisabio.portalinvestigacion.com/publicaciones/9289
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MOSBY-ELSEVIER
publisher.none.fl_str_mv MOSBY-ELSEVIER
dc.source.none.fl_str_mv JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
ISSN: 08947317
ISSNe: 10976795
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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