Investigating Efficient Risk-Stratified Pathways for the Early Detection of Clinically Significant Prostate Cancer

Risk-stratified pathways (RSPs) are recommended by the European Association of Uro-logy (EAU) to improve the early detection of clinically significant prostate cancer (csPCa). RSPs can reduce magnetic resonance imaging (MRI) demand, prostate biopsies, and the over-detection of insignificant PCa (iPC...

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Detalles Bibliográficos
Autores: Morote Robles, Juan|||0000-0002-2168-323X, Borque-Fernando, Ángel|||0000-0003-0178-4567, Esteban, Luis M.|||0000-0002-3007-302X, Celma, Ana|||0000-0002-3128-3811, Campistol i Torres, Miriam|||0000-0002-3212-3473, Miró, Berta|||0000-0001-6049-8697, Méndez Fernández, Olga|||0000-0003-4237-330X, Trilla Herrera, Enrique|||0000-0001-9401-0872
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:304446
Acceso en línea:https://ddd.uab.cat/record/304446
https://dx.doi.org/urn:doi:10.3390/jpm14020130
Access Level:acceso abierto
Palabra clave:Screening
Prostate cancer
Barcelona risk calculator
Proclarix
Risk-stratified pathway
Descripción
Sumario:Risk-stratified pathways (RSPs) are recommended by the European Association of Uro-logy (EAU) to improve the early detection of clinically significant prostate cancer (csPCa). RSPs can reduce magnetic resonance imaging (MRI) demand, prostate biopsies, and the over-detection of insignificant PCa (iPCa). Our goal is to analyze the efficacy and cost-effectiveness of several RSPs by using sequential stratifications from the serum prostate-specific antigen level and digital rectal examination, the Barcelona risk calculators (BCN-RCs), MRI, and Proclarix™. In a cohort of 567 men with a serum PSA level above 3.0 ng/mL who underwent multiparametric MRI (mpMRI) and targeted and/or systematic biopsies, the risk of csPCa was retrospectively assessed using Proclarix™ and BCN-RCs 1 and 2. Six RSPs were compared with those recommended by the EAU that, stratifying men from MRI, avoided 16.7% of prostate biopsies with a prostate imaging-reporting and data system score of <3, with 2.6% of csPCa cases remaining undetected. The most effective RSP avoided mpMRI exams in men with a serum PSA level of.

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