Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles

The number of people suffering from mental health problems is rising, with anxiety and depression now the most commonly diagnosed psychiatric conditions. Selective serotonin reuptake inhibitors (SSRIs) are one of the most prescribed pharmaceuticals to treat these conditions, which has led to their c...

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Autores: Faria, Melissa, Bellot, Marina, Soto, Oscar, Prats, Eva, Montemurro, Nicola, Manjarrés, Diana, Gómez-Canela, Cristian, Raldúa, Demetrio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285001
Acceso en línea:http://hdl.handle.net/10261/285001
https://api.elsevier.com/content/abstract/scopus_id/85143362842
Access Level:acceso abierto
Palabra clave:Zebrafish larvae
Environmental concentrations
Neurotransmitters
Sertraline
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spelling Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profilesFaria, MelissaBellot, MarinaSoto, OscarPrats, EvaMontemurro, NicolaManjarrés, DianaGómez-Canela, CristianRaldúa, DemetrioZebrafish larvaeEnvironmental concentrationsNeurotransmittersSertralineThe number of people suffering from mental health problems is rising, with anxiety and depression now the most commonly diagnosed psychiatric conditions. Selective serotonin reuptake inhibitors (SSRIs) are one of the most prescribed pharmaceuticals to treat these conditions, which has led to their common detection in many aquatic ecosystems. As the monoaminergic system shows a high degree of structural conservation across diverse animal phyla, a reasonable assumption is that the environmental levels of SSRIs in surface water can lead to adverse effects on fish and other aquatic wildlife. For instance, Sertraline (SER), a widely prescribed SSRI, has been shown to induce adverse effects in fish, albeit most of the reports used exposure concentrations exceeding those occurring in natural environments. Therefore, there is still a great lack of knowledge regarding SERs effects in fish species, especially during early life stages. This study describes the evaluation of developmental exposure of zebrafish (Danio rerio) to environmentally relevant concentrations of SER (from 0.01 to 10 μg/L), using a battery of key survival behaviors and further relating them with the expression of genes and neurochemical profiles of the monoaminergic system. We found that developmental exposure to SER did not affect embryo morphogenesis and growth. However, concentrations as low as 0.1 μg/L induced hypolocomotion and delayed learning. The observed behavioral impairment was associated with augmented serotonin levels rather than other neurochemicals and molecular markers, highlighting the relationship between serotonin signaling and behavior in zebrafish.This work was fundded by “Agencia Estatal de Investigación” from the Spanish Ministry of Science and Innovation (projects PID2020-113371RB-C21 and PID2020-113371RA-C22) and by IDAEA-CSIC, Severo Ochoa Centre of Excellence (CEX2018-000794-S).Peer reviewedFrontiers MediaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/285001https://api.elsevier.com/content/abstract/scopus_id/85143362842reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésFrontiers in physiologyhttps://doi.org/10.3389/fphys.2022.1040598Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2850012026-05-22T06:33:51Z
dc.title.none.fl_str_mv Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
title Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
spellingShingle Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
Faria, Melissa
Zebrafish larvae
Environmental concentrations
Neurotransmitters
Sertraline
title_short Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
title_full Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
title_fullStr Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
title_full_unstemmed Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
title_sort Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles
dc.creator.none.fl_str_mv Faria, Melissa
Bellot, Marina
Soto, Oscar
Prats, Eva
Montemurro, Nicola
Manjarrés, Diana
Gómez-Canela, Cristian
Raldúa, Demetrio
author Faria, Melissa
author_facet Faria, Melissa
Bellot, Marina
Soto, Oscar
Prats, Eva
Montemurro, Nicola
Manjarrés, Diana
Gómez-Canela, Cristian
Raldúa, Demetrio
author_role author
author2 Bellot, Marina
Soto, Oscar
Prats, Eva
Montemurro, Nicola
Manjarrés, Diana
Gómez-Canela, Cristian
Raldúa, Demetrio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Zebrafish larvae
Environmental concentrations
Neurotransmitters
Sertraline
topic Zebrafish larvae
Environmental concentrations
Neurotransmitters
Sertraline
description The number of people suffering from mental health problems is rising, with anxiety and depression now the most commonly diagnosed psychiatric conditions. Selective serotonin reuptake inhibitors (SSRIs) are one of the most prescribed pharmaceuticals to treat these conditions, which has led to their common detection in many aquatic ecosystems. As the monoaminergic system shows a high degree of structural conservation across diverse animal phyla, a reasonable assumption is that the environmental levels of SSRIs in surface water can lead to adverse effects on fish and other aquatic wildlife. For instance, Sertraline (SER), a widely prescribed SSRI, has been shown to induce adverse effects in fish, albeit most of the reports used exposure concentrations exceeding those occurring in natural environments. Therefore, there is still a great lack of knowledge regarding SERs effects in fish species, especially during early life stages. This study describes the evaluation of developmental exposure of zebrafish (Danio rerio) to environmentally relevant concentrations of SER (from 0.01 to 10 μg/L), using a battery of key survival behaviors and further relating them with the expression of genes and neurochemical profiles of the monoaminergic system. We found that developmental exposure to SER did not affect embryo morphogenesis and growth. However, concentrations as low as 0.1 μg/L induced hypolocomotion and delayed learning. The observed behavioral impairment was associated with augmented serotonin levels rather than other neurochemicals and molecular markers, highlighting the relationship between serotonin signaling and behavior in zebrafish.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285001
https://api.elsevier.com/content/abstract/scopus_id/85143362842
url http://hdl.handle.net/10261/285001
https://api.elsevier.com/content/abstract/scopus_id/85143362842
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in physiology
https://doi.org/10.3389/fphys.2022.1040598
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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