mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars

One of the most important threats to global human health is the increasing incidences of metabolic pathologies (including obesity, type 2 diabetes and non-alcoholic fatty liver disease), which is paralleled by increasing consumptions of hypercaloric diets enriched in simple sugars. The challenge is...

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Autores: Sangüesa Puigventós, Gemma, Roglans i Ribas, Núria, Baena Muñoz, Miguel, Velázquez, Ana Magdalena, Laguna Egea, Juan Carlos, Alegret i Jordà, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/133317
Acceso en línea:https://hdl.handle.net/2445/133317
Access Level:acceso abierto
Palabra clave:Metabolisme
Diabetis
Obesitat
Bioquímica
Sucres
Regulació del metabolisme
Metabolism
Diabetes
Obesity
Biochemistry
Sugars
Metabolic regulation
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spelling mTOR is a Key Protein Involved in the Metabolic Effects of Simple SugarsSangüesa Puigventós, GemmaRoglans i Ribas, NúriaBaena Muñoz, MiguelVelázquez, Ana MagdalenaLaguna Egea, Juan CarlosAlegret i Jordà, MartaMetabolismeDiabetisObesitatBioquímicaSucresRegulació del metabolismeMetabolismDiabetesObesityBiochemistrySugarsMetabolic regulationOne of the most important threats to global human health is the increasing incidences of metabolic pathologies (including obesity, type 2 diabetes and non-alcoholic fatty liver disease), which is paralleled by increasing consumptions of hypercaloric diets enriched in simple sugars. The challenge is to identify the metabolic pathways affected by the excessive consumption of these dietary components when they are consumed in excess, to unravel the molecular mechanisms leading to metabolic pathologies and identify novel therapeutic targets to manage them. Mechanistic (mammalian) target of rapamycin (mTOR) has emerged as one of the key molecular nodes that integrate extracellular signals, such as energy status and nutrient availability, to trigger cell responses that could lead to the above-mentioned diseases through the regulation of lipid and glucose metabolism. By activating mTOR signalling, excessive consumption of simple sugars (such as fructose and glucose), could modulate hepatic gluconeogenesis, lipogenesis and fatty acid uptake and catabolism and thus lipid deposition in the liver. In the present review we will discuss some of the most recent studies showing the central role of mTOR in the metabolic effects of excessive simple sugar consumption.MDPI2019201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/133317Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms20051117International Journal of Molecular Sciences, 2019, vol. 20, num. 5, p. 1117https://doi.org/10.3390/ijms20051117cc-by (c) Sangüesa Puigventós, Gemma et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1333172026-05-29T05:05:01Z
dc.title.none.fl_str_mv mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
title mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
spellingShingle mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
Sangüesa Puigventós, Gemma
Metabolisme
Diabetis
Obesitat
Bioquímica
Sucres
Regulació del metabolisme
Metabolism
Diabetes
Obesity
Biochemistry
Sugars
Metabolic regulation
title_short mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
title_full mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
title_fullStr mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
title_full_unstemmed mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
title_sort mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
dc.creator.none.fl_str_mv Sangüesa Puigventós, Gemma
Roglans i Ribas, Núria
Baena Muñoz, Miguel
Velázquez, Ana Magdalena
Laguna Egea, Juan Carlos
Alegret i Jordà, Marta
author Sangüesa Puigventós, Gemma
author_facet Sangüesa Puigventós, Gemma
Roglans i Ribas, Núria
Baena Muñoz, Miguel
Velázquez, Ana Magdalena
Laguna Egea, Juan Carlos
Alegret i Jordà, Marta
author_role author
author2 Roglans i Ribas, Núria
Baena Muñoz, Miguel
Velázquez, Ana Magdalena
Laguna Egea, Juan Carlos
Alegret i Jordà, Marta
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Metabolisme
Diabetis
Obesitat
Bioquímica
Sucres
Regulació del metabolisme
Metabolism
Diabetes
Obesity
Biochemistry
Sugars
Metabolic regulation
topic Metabolisme
Diabetis
Obesitat
Bioquímica
Sucres
Regulació del metabolisme
Metabolism
Diabetes
Obesity
Biochemistry
Sugars
Metabolic regulation
description One of the most important threats to global human health is the increasing incidences of metabolic pathologies (including obesity, type 2 diabetes and non-alcoholic fatty liver disease), which is paralleled by increasing consumptions of hypercaloric diets enriched in simple sugars. The challenge is to identify the metabolic pathways affected by the excessive consumption of these dietary components when they are consumed in excess, to unravel the molecular mechanisms leading to metabolic pathologies and identify novel therapeutic targets to manage them. Mechanistic (mammalian) target of rapamycin (mTOR) has emerged as one of the key molecular nodes that integrate extracellular signals, such as energy status and nutrient availability, to trigger cell responses that could lead to the above-mentioned diseases through the regulation of lipid and glucose metabolism. By activating mTOR signalling, excessive consumption of simple sugars (such as fructose and glucose), could modulate hepatic gluconeogenesis, lipogenesis and fatty acid uptake and catabolism and thus lipid deposition in the liver. In the present review we will discuss some of the most recent studies showing the central role of mTOR in the metabolic effects of excessive simple sugar consumption.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/133317
url https://hdl.handle.net/2445/133317
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms20051117
International Journal of Molecular Sciences, 2019, vol. 20, num. 5, p. 1117
https://doi.org/10.3390/ijms20051117
dc.rights.none.fl_str_mv cc-by (c) Sangüesa Puigventós, Gemma et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sangüesa Puigventós, Gemma et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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