The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription...
| Autores: | , |
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| Formato: | artículo |
| Estado: | Versión enviada para evaluación y publicación |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/127908 |
| Acesso em linha: | https://hdl.handle.net/11441/127908 https://doi.org/10.1080/23723556.2021.1976582 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cancer cBAF Chromatin Epigenetics Genome instability R-loops SWI/SNF Transcription-replication conflicts |
| Resumo: | Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription-replication conflicts. Here we discuss the significance and biomedical applications of this finding. |
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