The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential

Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription...

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Detalles Bibliográficos
Autores: Bayona Feliu, Aleix, Aguilera López, Andrés
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/127908
Acceso en línea:https://hdl.handle.net/11441/127908
https://doi.org/10.1080/23723556.2021.1976582
Access Level:acceso abierto
Palabra clave:Cancer
cBAF
Chromatin
Epigenetics
Genome instability
R-loops
SWI/SNF
Transcription-replication conflicts
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spelling The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potentialBayona Feliu, AleixAguilera López, AndrésCancercBAFChromatinEpigeneticsGenome instabilityR-loopsSWI/SNFTranscription-replication conflictsGenome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription-replication conflicts. Here we discuss the significance and biomedical applications of this finding.Taylor & FrancisGenética2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/127908https://doi.org/10.1080/23723556.2021.1976582reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésMolecular and Cellular Oncology, 1976582.https://doi.org/10.1080/23723556.2021.1976582info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1279082026-06-17T12:51:07Z
dc.title.none.fl_str_mv The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
title The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
spellingShingle The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
Bayona Feliu, Aleix
Cancer
cBAF
Chromatin
Epigenetics
Genome instability
R-loops
SWI/SNF
Transcription-replication conflicts
title_short The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
title_full The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
title_fullStr The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
title_full_unstemmed The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
title_sort The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
dc.creator.none.fl_str_mv Bayona Feliu, Aleix
Aguilera López, Andrés
author Bayona Feliu, Aleix
author_facet Bayona Feliu, Aleix
Aguilera López, Andrés
author_role author
author2 Aguilera López, Andrés
author2_role author
dc.contributor.none.fl_str_mv Genética
dc.subject.none.fl_str_mv Cancer
cBAF
Chromatin
Epigenetics
Genome instability
R-loops
SWI/SNF
Transcription-replication conflicts
topic Cancer
cBAF
Chromatin
Epigenetics
Genome instability
R-loops
SWI/SNF
Transcription-replication conflicts
description Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription-replication conflicts. Here we discuss the significance and biomedical applications of this finding.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/127908
https://doi.org/10.1080/23723556.2021.1976582
url https://hdl.handle.net/11441/127908
https://doi.org/10.1080/23723556.2021.1976582
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular and Cellular Oncology, 1976582.
https://doi.org/10.1080/23723556.2021.1976582
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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