The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential

Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription...

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Bibliographic Details
Authors: Bayona Feliu, Aleix, Aguilera López, Andrés
Format: article
Status:Versión enviada para evaluación y publicación
Publication Date:2021
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/127908
Online Access:https://hdl.handle.net/11441/127908
https://doi.org/10.1080/23723556.2021.1976582
Access Level:Open access
Keyword:Cancer
cBAF
Chromatin
Epigenetics
Genome instability
R-loops
SWI/SNF
Transcription-replication conflicts
Description
Summary:Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription-replication conflicts. Here we discuss the significance and biomedical applications of this finding.

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