Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.

Background: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression...

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Autores: Siewert, Katherine M., Klarin, Derek, Damrauer, Scott M., Chang, Kyong-Mi, Tsao, Philip S., Assimes, Themistocles L., Smith, George Davey, Voight, Benjamin F., The International Headache Genetics Consortium, Cormand Rifà, Bru
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/194711
Acceso en línea:https://hdl.handle.net/2445/194711
Access Level:acceso abierto
Palabra clave:Migranya
Cefalàlgia
Migraine
Headache
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spelling Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.Siewert, Katherine M.Klarin, DerekDamrauer, Scott M.Chang, Kyong-MiTsao, Philip S.Assimes, Themistocles L.Smith, George DaveyVoight, Benjamin F.The International Headache Genetics ConsortiumCormand Rifà, BruMigranyaCefalàlgiaMigraineHeadacheBackground: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available. Results: We report multiple phenotypes with genetic correlation (P < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine. Conclusions: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci.Oxford University Press2023202320202023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/194711Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1093/ije/dyaa050International Journal of Epidemiology, 2020, vol. 49, num. 3, p. 1022-1031https://doi.org/10.1093/ije/dyaa050cc by (c) Siewert, Katherine M. et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1947112026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
title Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
spellingShingle Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
Siewert, Katherine M.
Migranya
Cefalàlgia
Migraine
Headache
title_short Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
title_full Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
title_fullStr Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
title_full_unstemmed Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
title_sort Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
dc.creator.none.fl_str_mv Siewert, Katherine M.
Klarin, Derek
Damrauer, Scott M.
Chang, Kyong-Mi
Tsao, Philip S.
Assimes, Themistocles L.
Smith, George Davey
Voight, Benjamin F.
The International Headache Genetics Consortium
Cormand Rifà, Bru
author Siewert, Katherine M.
author_facet Siewert, Katherine M.
Klarin, Derek
Damrauer, Scott M.
Chang, Kyong-Mi
Tsao, Philip S.
Assimes, Themistocles L.
Smith, George Davey
Voight, Benjamin F.
The International Headache Genetics Consortium
Cormand Rifà, Bru
author_role author
author2 Klarin, Derek
Damrauer, Scott M.
Chang, Kyong-Mi
Tsao, Philip S.
Assimes, Themistocles L.
Smith, George Davey
Voight, Benjamin F.
The International Headache Genetics Consortium
Cormand Rifà, Bru
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Migranya
Cefalàlgia
Migraine
Headache
topic Migranya
Cefalàlgia
Migraine
Headache
description Background: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available. Results: We report multiple phenotypes with genetic correlation (P < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine. Conclusions: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci.
publishDate 2020
dc.date.none.fl_str_mv 2020
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/194711
url https://hdl.handle.net/2445/194711
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/ije/dyaa050
International Journal of Epidemiology, 2020, vol. 49, num. 3, p. 1022-1031
https://doi.org/10.1093/ije/dyaa050
dc.rights.none.fl_str_mv cc by (c) Siewert, Katherine M. et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Siewert, Katherine M. et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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