Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma

Palpan Jr., Alexis; Vivancos Sanchez, Catalina; Roda, José M.; Cerdán, Sebastián; Barrios, Andrés Javier; Utrilla, Cristina; Royo, Aranzazu; Gandía-González, María L.

Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma

Detalles Bibliográficos
Autores:	Palpan Jr., Alexis, Vivancos Sanchez, Catalina, Roda, José M., Cerdán, Sebastián, Barrios, Andrés Javier, Utrilla, Cristina, Royo, Aranzazu, Gandía-González, María L.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/231843
Acceso en línea:	http://hdl.handle.net/10261/231843
Access Level:	acceso abierto
Palabra clave:	Glioblastoma Overall survival Progression free survival IDH mutation Tumor volumetry Linear method Semi-automatic segmentation method Ellipsoid method

id	ES_852db3faa3d29d032d17a3883e123e1f
oai_identifier_str	oai:digital.csic.es:10261/231843
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH GlioblastomaPalpan Jr., AlexisVivancos Sanchez, CatalinaRoda, José M.Cerdán, SebastiánBarrios, Andrés JavierUtrilla, CristinaRoyo, AranzazuGandía-González, María L.GlioblastomaOverall survivalProgression free survivalIDH mutationTumor volumetryLinear methodSemi-automatic segmentation methodEllipsoid method© 2020 Palpan Flores, Vivancos Sanchez, Roda, Cerdán, Barrios, Utrilla, Royo and Gandía González.[Objective]: We evaluate the performance of three MRI methods to determine non-invasively tumor size, as overall survival (OS) and Progression Free Survival (PFS) predictors, in a cohort of wild type, IDH negative, glioblastoma patients. Investigated protocols included bidimensional (2D) diameter measurements, and three-dimensional (3D) estimations by the ellipsoid or semi-automatic segmentation methods. [Methods]: We investigated OS in a cohort of 44 patients diagnosed with wild type IDH glioblastoma (58.2 ± 11.4 years, 1.9/1 male/female) treated with neurosurgical resection followed by adjuvant chemo and radiotherapy. Pre-operative MRI images were evaluated to determine tumor mass area and volume, gadolinium enhancement volume, necrosis volume, and FLAIR-T2 hyper-intensity area and volume. We implemented then multivariate Cox statistical analysis to select optimal predictors for OS and PFS. [Results]: Median OS was 16 months (1–42 months), ranging from 9 ± 2.4 months in patients over 65 years, to 18 ± 1.6 months in younger ones. Patients with tumors carrying O6-methylguanin-DNA-methyltransferase (MGMT) methylation survived 30 ± 5.2 vs. 13 ± 2.5 months in non-methylated. Our study evidenced high and positive correlations among the results of the three methods to determine tumor size. FLAIR-T2 hyper-intensity areas (2D) and volumes (3D) were also similar as determined by the three methods. Cox proportional hazards analysis with the 2D and 3D methods indicated that OS was associated to age ≥ 65 years (HR 2.70, 2.94, and 3.16), MGMT methylation (HR 2.98, 3.07, and 2.90), and FLAIR-T2 ≥ 2,000 mm2 or ≥60 cm3 (HR 4.16, 3.93, and 3.72), respectively. Other variables including necrosis, tumor mass, necrosis/tumor ratio, and FLAIR/tumor ratio were not significantly correlated with OS. [Conclusion]: Our results reveal a high correlation among measurements of tumor size performed with the three methods. Pre-operative FLAIR-T2 hyperintensity area and volumes provided, independently of the measurement method, the optimal neuroimaging features predicting OS in primary glioblastoma patients, followed by age ≥ 65 years and MGMT methylation.This work was supported in part by grants PI 2017/00361 from Instituto de Salud Carlos III to JR, MG, and AP and by grant B2017/BMD3688 from the Community of Madrid to JR, MG, and SC.Frontiers MediaInstituto de Salud Carlos IIIComunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/231843reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#B2017/BMD3688/MULTI-TARGET&VIEW-CMhttp://dx.doi.org/10.3389/fonc.2020.01662Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2318432026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
title	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
spellingShingle	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma Palpan Jr., Alexis Glioblastoma Overall survival Progression free survival IDH mutation Tumor volumetry Linear method Semi-automatic segmentation method Ellipsoid method
title_short	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
title_full	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
title_fullStr	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
title_full_unstemmed	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
title_sort	Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
dc.creator.none.fl_str_mv	Palpan Jr., Alexis Vivancos Sanchez, Catalina Roda, José M. Cerdán, Sebastián Barrios, Andrés Javier Utrilla, Cristina Royo, Aranzazu Gandía-González, María L.
author	Palpan Jr., Alexis
author_facet	Palpan Jr., Alexis Vivancos Sanchez, Catalina Roda, José M. Cerdán, Sebastián Barrios, Andrés Javier Utrilla, Cristina Royo, Aranzazu Gandía-González, María L.
author_role	author
author2	Vivancos Sanchez, Catalina Roda, José M. Cerdán, Sebastián Barrios, Andrés Javier Utrilla, Cristina Royo, Aranzazu Gandía-González, María L.
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Instituto de Salud Carlos III Comunidad de Madrid Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Glioblastoma Overall survival Progression free survival IDH mutation Tumor volumetry Linear method Semi-automatic segmentation method Ellipsoid method
topic	Glioblastoma Overall survival Progression free survival IDH mutation Tumor volumetry Linear method Semi-automatic segmentation method Ellipsoid method
description	© 2020 Palpan Flores, Vivancos Sanchez, Roda, Cerdán, Barrios, Utrilla, Royo and Gandía González.
publishDate	2020
dc.date.none.fl_str_mv	2020 2021 2021 2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/231843
url	http://hdl.handle.net/10261/231843
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	#PLACEHOLDER_PARENT_METADATA_VALUE# B2017/BMD3688/MULTI-TARGET&VIEW-CM http://dx.doi.org/10.3389/fonc.2020.01662 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Frontiers Media
publisher.none.fl_str_mv	Frontiers Media
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869412278811492352
score	15,811543

Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma

Similares en LA Referencia