What lies beneath? Molecular evolution during the radiation of caecilian amphibians

Background Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived phenotypes, and ecological ranges can provide insights into adaptive...

Descripción completa

Detalles Bibliográficos
Autores: Torres-Sánchez, María, Gower, David J., Álvarez-Ponce, David, Creevey, Christopher J., Wilkinson, Mark, San Mauro, Diego
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12337
Acceso en línea:https://hdl.handle.net/20.500.14352/12337
Access Level:acceso abierto
Palabra clave:574
575.8
597.6
Ecological opportunity
gene ontology
Gymnophiona
positive selection signatures
vertebrate evolution
Anfibios
Ecología (Biología)
Evolución
2401.17 Invertebrados
2401.06 Ecología animal
id ES_84f481e83d7cab78f5e1aba83f8ec978
oai_identifier_str oai:docta.ucm.es:20.500.14352/12337
network_acronym_str ES
network_name_str España
repository_id_str
spelling What lies beneath? Molecular evolution during the radiation of caecilian amphibiansTorres-Sánchez, MaríaGower, David J.Álvarez-Ponce, DavidCreevey, Christopher J.Wilkinson, MarkSan Mauro, Diego574575.8597.6Ecological opportunitygene ontologyGymnophionapositive selection signaturesvertebrate evolutionAnfibiosEcología (Biología)Evolución2401.17 Invertebrados2401.06 Ecología animalBackground Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived phenotypes, and ecological ranges can provide insights into adaptive radiations. Caecilians (order Gymnophiona), probably the least known of the major lineages of vertebrates, are limbless tropical amphibians, with adults of most species burrowing in soils (fossoriality). This enigmatic order of amphibians are very distinct phenotypically from other extant amphibians and likely from the ancestor of Lissamphibia, but little to nothing is known about the molecular changes underpinning their radiation. We hypothesised that colonization of various depths of tropical soils and of freshwater habitats presented new ecological opportunities to caecilians. Results A total of 8540 candidate groups of orthologous genes from transcriptomic data of five species of caecilian amphibians and the genome of the frog Xenopus tropicalis were analysed in order to investigate the genetic machinery behind caecilian diversification. We found a total of 168 protein-coding genes with signatures of positive selection at different evolutionary times during the radiation of caecilians. The majority of these genes were related to functional elements of the cell membrane and extracellular matrix with expression in several different tissues. The first colonization of the tropical soils was connected to the largest number of protein-coding genes under positive selection in our analysis. From the results of our study, we highlighted molecular changes in genes involved in perception, reduction-oxidation processes, and aging that likely were involved in the adaptation to different soil strata. Conclusions The genes inferred to have been under positive selection provide valuable insights into caecilian evolution, potentially underpin adaptations of caecilians to their extreme environments, and contribute to a better understanding of fossorial adaptations and molecular evolution in vertebrates.BMCUniversidad Complutense de Madrid20192019-05-0920192019-05-09journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12337reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/123372026-06-02T12:44:21Z
dc.title.none.fl_str_mv What lies beneath? Molecular evolution during the radiation of caecilian amphibians
title What lies beneath? Molecular evolution during the radiation of caecilian amphibians
spellingShingle What lies beneath? Molecular evolution during the radiation of caecilian amphibians
Torres-Sánchez, María
574
575.8
597.6
Ecological opportunity
gene ontology
Gymnophiona
positive selection signatures
vertebrate evolution
Anfibios
Ecología (Biología)
Evolución
2401.17 Invertebrados
2401.06 Ecología animal
title_short What lies beneath? Molecular evolution during the radiation of caecilian amphibians
title_full What lies beneath? Molecular evolution during the radiation of caecilian amphibians
title_fullStr What lies beneath? Molecular evolution during the radiation of caecilian amphibians
title_full_unstemmed What lies beneath? Molecular evolution during the radiation of caecilian amphibians
title_sort What lies beneath? Molecular evolution during the radiation of caecilian amphibians
dc.creator.none.fl_str_mv Torres-Sánchez, María
Gower, David J.
Álvarez-Ponce, David
Creevey, Christopher J.
Wilkinson, Mark
San Mauro, Diego
author Torres-Sánchez, María
author_facet Torres-Sánchez, María
Gower, David J.
Álvarez-Ponce, David
Creevey, Christopher J.
Wilkinson, Mark
San Mauro, Diego
author_role author
author2 Gower, David J.
Álvarez-Ponce, David
Creevey, Christopher J.
Wilkinson, Mark
San Mauro, Diego
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 574
575.8
597.6
Ecological opportunity
gene ontology
Gymnophiona
positive selection signatures
vertebrate evolution
Anfibios
Ecología (Biología)
Evolución
2401.17 Invertebrados
2401.06 Ecología animal
topic 574
575.8
597.6
Ecological opportunity
gene ontology
Gymnophiona
positive selection signatures
vertebrate evolution
Anfibios
Ecología (Biología)
Evolución
2401.17 Invertebrados
2401.06 Ecología animal
description Background Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived phenotypes, and ecological ranges can provide insights into adaptive radiations. Caecilians (order Gymnophiona), probably the least known of the major lineages of vertebrates, are limbless tropical amphibians, with adults of most species burrowing in soils (fossoriality). This enigmatic order of amphibians are very distinct phenotypically from other extant amphibians and likely from the ancestor of Lissamphibia, but little to nothing is known about the molecular changes underpinning their radiation. We hypothesised that colonization of various depths of tropical soils and of freshwater habitats presented new ecological opportunities to caecilians. Results A total of 8540 candidate groups of orthologous genes from transcriptomic data of five species of caecilian amphibians and the genome of the frog Xenopus tropicalis were analysed in order to investigate the genetic machinery behind caecilian diversification. We found a total of 168 protein-coding genes with signatures of positive selection at different evolutionary times during the radiation of caecilians. The majority of these genes were related to functional elements of the cell membrane and extracellular matrix with expression in several different tissues. The first colonization of the tropical soils was connected to the largest number of protein-coding genes under positive selection in our analysis. From the results of our study, we highlighted molecular changes in genes involved in perception, reduction-oxidation processes, and aging that likely were involved in the adaptation to different soil strata. Conclusions The genes inferred to have been under positive selection provide valuable insights into caecilian evolution, potentially underpin adaptations of caecilians to their extreme environments, and contribute to a better understanding of fossorial adaptations and molecular evolution in vertebrates.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-05-09
2019
2019-05-09
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12337
url https://hdl.handle.net/20.500.14352/12337
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412262811271168
score 15,301603

Similares en LA Referencia