Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering

Nanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing and supercritical carbon dioxide (scCO2) technologies are innovative processing strategies that, when combined, allow the...

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Authors: Iglesias-Mejuto, Ana, Malandain, Nanthilde, Ferreira-Gonçalves, Tânia, Ardao Palacios, Inés, Pinto Reis, Catarina, Laromaine, Anna, Roig, Anna, García González, Carlos A.
Format: article
Publication Date:2023
Country:España
Institution:Universidad de Santiago de Compostela (USC)
Repository:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Language:English
OAI Identifier:oai:minerva.usc.gal:10347/45768
Online Access:https://hdl.handle.net/10347/45768
Access Level:Open access
Keyword:Aerogeles
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spelling Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineeringIglesias-Mejuto, AnaMalandain, NanthildeFerreira-Gonçalves, TâniaArdao Palacios, InésPinto Reis, CatarinaLaromaine, AnnaRoig, AnnaGarcía González, Carlos A.AerogelesNanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing and supercritical carbon dioxide (scCO2) technologies are innovative processing strategies that, when combined, allow the precise fabrication of highly porous aerogel scaffolds. Novel sterile cellulose-in-cellulose aerogels decorated with superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized in this work by an integrated technological platform based on 3D-printing and scCO2. Methylcellulose (MC) and bacterial nanocellulose (BC) are two versatile cellulosic polysaccharides with remarkable physicochemical and biological performances, whereas SPIONs are commonly used to functionalize biomaterials aimed at tissue engineering. Aerogels with hierarchical porosity and high structural resolution were obtained according to nitrogen adsorption–desorption analysis, confocal, scanning and transmission microscopies (SEM and TEM). The magnetic properties of SPIONsdoped aerogels confirmed the correct functionalization of the nanostructures. Finally, NIH/3T3 fibroblast cell viability, hemocompatibility with human blood and safety tests (in ovo with HET-CAM and in vivo with Artemia salina) indicate the biocompatibility of the cellulose-in-cellulose aerogels.SpringerUniversidade de Santiago de Compostela. Facultade de FarmaciaUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS)Universidade de Santiago de Compostela. Instituto de Materiais (iMATUS)20232023-12-1220232023-12-12journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/45768reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-120010RB-I00 INGENIERIA DE AEROGELES PARA APLICACIONES BIOMEDICAS AVANZADASAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PDC2022-133526-I00 DESARROLLO DE PROTOTIPO AVANZADO PARA LA ESTERILIZACION DE PRODUCTOS SANITARIOS Y MEDICAMENTOSAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-122645OB-I00 NANOCOMPOSITES BLANDOS Y FUNCIONALES A BASE DE POLIMEROS NATURALES PARA LA REGENERACION DE TEJIDOSopen accesshttp://purl.org/coar/access_right/c_abf2© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/457682026-06-15T12:47:27Z
dc.title.none.fl_str_mv Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
title Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
spellingShingle Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
Iglesias-Mejuto, Ana
Aerogeles
title_short Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
title_full Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
title_fullStr Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
title_full_unstemmed Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
title_sort Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
dc.creator.none.fl_str_mv Iglesias-Mejuto, Ana
Malandain, Nanthilde
Ferreira-Gonçalves, Tânia
Ardao Palacios, Inés
Pinto Reis, Catarina
Laromaine, Anna
Roig, Anna
García González, Carlos A.
author Iglesias-Mejuto, Ana
author_facet Iglesias-Mejuto, Ana
Malandain, Nanthilde
Ferreira-Gonçalves, Tânia
Ardao Palacios, Inés
Pinto Reis, Catarina
Laromaine, Anna
Roig, Anna
García González, Carlos A.
author_role author
author2 Malandain, Nanthilde
Ferreira-Gonçalves, Tânia
Ardao Palacios, Inés
Pinto Reis, Catarina
Laromaine, Anna
Roig, Anna
García González, Carlos A.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Facultade de Farmacia
Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS)
Universidade de Santiago de Compostela. Instituto de Materiais (iMATUS)
dc.subject.none.fl_str_mv Aerogeles
topic Aerogeles
description Nanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing and supercritical carbon dioxide (scCO2) technologies are innovative processing strategies that, when combined, allow the precise fabrication of highly porous aerogel scaffolds. Novel sterile cellulose-in-cellulose aerogels decorated with superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized in this work by an integrated technological platform based on 3D-printing and scCO2. Methylcellulose (MC) and bacterial nanocellulose (BC) are two versatile cellulosic polysaccharides with remarkable physicochemical and biological performances, whereas SPIONs are commonly used to functionalize biomaterials aimed at tissue engineering. Aerogels with hierarchical porosity and high structural resolution were obtained according to nitrogen adsorption–desorption analysis, confocal, scanning and transmission microscopies (SEM and TEM). The magnetic properties of SPIONsdoped aerogels confirmed the correct functionalization of the nanostructures. Finally, NIH/3T3 fibroblast cell viability, hemocompatibility with human blood and safety tests (in ovo with HET-CAM and in vivo with Artemia salina) indicate the biocompatibility of the cellulose-in-cellulose aerogels.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-12-12
2023
2023-12-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/45768
url https://hdl.handle.net/10347/45768
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-120010RB-I00 INGENIERIA DE AEROGELES PARA APLICACIONES BIOMEDICAS AVANZADAS
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PDC2022-133526-I00 DESARROLLO DE PROTOTIPO AVANZADO PARA LA ESTERILIZACION DE PRODUCTOS SANITARIOS Y MEDICAMENTOS
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-122645OB-I00 NANOCOMPOSITES BLANDOS Y FUNCIONALES A BASE DE POLIMEROS NATURALES PARA LA REGENERACION DE TEJIDOS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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