Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis

PC receives a salary by an Intensification/Post-Residency Grant from Research Committee of the University Hospital of Bellvitge (HUB; Barcelona, Spain) 2019-2021. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was n...

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Autores: Cerdà, Pau, Ribas, Jesús, Iriarte, Adriana, Mora-Luján, José María, Torres, Raquel, Del Río, Belén, Jofre, Héctor Ignacio, Ruiz, Yolanda, Huguet, Marta, Fuset, Mari Paz, Martínez-Yélamos, Sergio, Santos, Salud, Llecha, Núria, Corbella Virós, Xavier, Riera-Mestre, Antoni
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/1971
Acceso en línea:http://hdl.handle.net/20.500.12328/1971
https://dx.doi.org/10.1371/journal.pone.0243533
Access Level:acceso abierto
Palabra clave:Embòlia pulmonar
Hospitals--Pacients
COVID-19 (Malaltia)
Corticosteroides
Embolia pulmonar
Hospitalizados
COVID-19
Pulmonary embolism
Hospitals--Patients
Corticosteroids
61
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oai_identifier_str oai:recercat.cat:20.500.12328/1971
network_acronym_str ES
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repository_id_str
spelling Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosisCerdà, PauRibas, JesúsIriarte, AdrianaMora-Luján, José MaríaTorres, RaquelDel Río, BelénJofre, Héctor IgnacioRuiz, YolandaHuguet, MartaFuset, Mari PazMartínez-Yélamos, SergioSantos, SaludLlecha, NúriaCorbella Virós, XavierRiera-Mestre, AntoniEmbòlia pulmonarHospitals--PacientsCOVID-19 (Malaltia)CorticosteroidesEmbolia pulmonarHospitalizadosCOVID-19CorticosteroidesPulmonary embolismHospitals--PatientsCOVID-19Corticosteroids61PC receives a salary by an Intensification/Post-Residency Grant from Research Committee of the University Hospital of Bellvitge (HUB; Barcelona, Spain) 2019-2021. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.Background: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with COVID-19. The main objective was to assess clinical and laboratory differences in hospitalized COVID-19 patients according to occurrence of PE. Methods: This retrospective study included all consecutive patients hospitalized with COVID-19 who underwent a computed tomography (CT) angiography for PE clinical suspicion. Clinical data and median blood test results distributed into weekly periods from COVID-19 symptoms onset, were compared between PE and non-PE patients. Results: Ninety-two patients were included, 29 (32%) had PE. PE patients were younger (63.9 (SD 13.7) vs 69.9 (SD 12.5) years). Clinical symptoms and COVID-19 CT features were similar in both groups. PE was diagnosed after a mean of 20.0 (SD 8.6) days from the onset of COVID-19 symptoms. Corticosteroid boluses were more frequently used in PE patients (62% vs. 43%). No patients met ISTH DIC criteria. Any parameter was statistically significant or clinically relevant except for D-Dimer when comparing both groups. Median values [IQR] of D-dimer in PE vs non-PE patients were: week 2 (2010.7 [770.1–11208.9] vs 626.0 [374.0–2382.2]; p = 0.004); week 3 (3893.1 [1388.2–6694.0] vs 1184.4 [461.8–2447.8]; p = 0.003); and week 4 (2736.3 [1202.1–8514.1] vs 1129.1 [542.5–2834.6]; p = 0.01). Median fold-increase of D-dimer between week 1 and 2 differed between groups (6.64 [3.02–23.05] vs 1.57 [0.64–2.71], p = 0.003); ROC curve AUC was 0.879 (p = 0.003) with a sensitivity and specificity for PE of 86% and 80%, respectively. Conclusions: Among hospitalized COVID-19 patients, D-dimer levels are higher at weeks 2, 3 and 4 after COVID-19 symptom onset in patients who develop PE. This difference is more pronounced when the fold increase between weeks 1 and 2 is compared.info:eu-repo/semantics/publishedVersionPublic Library of Science2020info:eu-repo/semantics/article15http://hdl.handle.net/20.500.12328/1971https://dx.doi.org/10.1371/journal.pone.0243533reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLoS One15;12©2020 Cerdà et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/19712026-05-29T05:05:01Z
dc.title.none.fl_str_mv Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
title Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
spellingShingle Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
Cerdà, Pau
Embòlia pulmonar
Hospitals--Pacients
COVID-19 (Malaltia)
Corticosteroides
Embolia pulmonar
Hospitalizados
COVID-19
Corticosteroides
Pulmonary embolism
Hospitals--Patients
COVID-19
Corticosteroids
61
title_short Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
title_full Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
title_fullStr Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
title_full_unstemmed Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
title_sort Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
dc.creator.none.fl_str_mv Cerdà, Pau
Ribas, Jesús
Iriarte, Adriana
Mora-Luján, José María
Torres, Raquel
Del Río, Belén
Jofre, Héctor Ignacio
Ruiz, Yolanda
Huguet, Marta
Fuset, Mari Paz
Martínez-Yélamos, Sergio
Santos, Salud
Llecha, Núria
Corbella Virós, Xavier
Riera-Mestre, Antoni
author Cerdà, Pau
author_facet Cerdà, Pau
Ribas, Jesús
Iriarte, Adriana
Mora-Luján, José María
Torres, Raquel
Del Río, Belén
Jofre, Héctor Ignacio
Ruiz, Yolanda
Huguet, Marta
Fuset, Mari Paz
Martínez-Yélamos, Sergio
Santos, Salud
Llecha, Núria
Corbella Virós, Xavier
Riera-Mestre, Antoni
author_role author
author2 Ribas, Jesús
Iriarte, Adriana
Mora-Luján, José María
Torres, Raquel
Del Río, Belén
Jofre, Héctor Ignacio
Ruiz, Yolanda
Huguet, Marta
Fuset, Mari Paz
Martínez-Yélamos, Sergio
Santos, Salud
Llecha, Núria
Corbella Virós, Xavier
Riera-Mestre, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embòlia pulmonar
Hospitals--Pacients
COVID-19 (Malaltia)
Corticosteroides
Embolia pulmonar
Hospitalizados
COVID-19
Corticosteroides
Pulmonary embolism
Hospitals--Patients
COVID-19
Corticosteroids
61
topic Embòlia pulmonar
Hospitals--Pacients
COVID-19 (Malaltia)
Corticosteroides
Embolia pulmonar
Hospitalizados
COVID-19
Corticosteroides
Pulmonary embolism
Hospitals--Patients
COVID-19
Corticosteroids
61
description PC receives a salary by an Intensification/Post-Residency Grant from Research Committee of the University Hospital of Bellvitge (HUB; Barcelona, Spain) 2019-2021. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/1971
https://dx.doi.org/10.1371/journal.pone.0243533
url http://hdl.handle.net/20.500.12328/1971
https://dx.doi.org/10.1371/journal.pone.0243533
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS One
15;12
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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