Differences Between Human and Murine Tau at the N-terminal End

Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the...

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Authors: Hernández, Félix, Merchán-Rubira, Jesús, Vallés-Saiz, Laura, Rodríguez-Matellán, Alberto, Ávila, Jesús
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/235843
Online Access:http://hdl.handle.net/10261/235843
Access Level:Open access
Keyword:Alzheimer’s disease
Human tau
Murine tau
Neurodegeneration
Tauopathies
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Differences Between Human and Murine Tau at the N-terminal EndHernández, FélixMerchán-Rubira, JesúsVallés-Saiz, LauraRodríguez-Matellán, AlbertoÁvila, JesúsAlzheimer’s diseaseHuman tauMurine tauNeurodegenerationTauopathiesHuman tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R isoforms are not present in adult mice. In contrast, the adult human brain contains Tau 3R and also Tau 4R isoforms. In addition, the N-terminal sequence of Tau protein in mice and humans differs, a Tau peptide (residues 17–28) being present in the latter but absent in the former. Here we review the main published data on this N-terminal sequence that suggests that human and mouse Tau proteins interact with different endogenous proteins and also show distinct secretion patterns.Spanish Ministry of Economy and Competitiveness (Ministerio de Economía, Industria y Competitividad, Gobierno de España; BFU2016-77885-P), Structural Funds of the European Union from the Comunidad de Madrid [S2017/BMD-3700 (NEUROMETABCM)], institutional funding from the Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII), and an institutional grant from the Fundación R. Areces. JM-R has a fellowship from the Fundación La Caixa.Ministerio de Economía y Competitividad (España)European CommissionComunidad de MadridCentro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)Fundación Ramón ArecesFundación la CaixaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/235843reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3389/fnagi.2020.00011Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2358432026-05-22T06:33:51Z
dc.title.none.fl_str_mv Differences Between Human and Murine Tau at the N-terminal End
title Differences Between Human and Murine Tau at the N-terminal End
spellingShingle Differences Between Human and Murine Tau at the N-terminal End
Hernández, Félix
Alzheimer’s disease
Human tau
Murine tau
Neurodegeneration
Tauopathies
title_short Differences Between Human and Murine Tau at the N-terminal End
title_full Differences Between Human and Murine Tau at the N-terminal End
title_fullStr Differences Between Human and Murine Tau at the N-terminal End
title_full_unstemmed Differences Between Human and Murine Tau at the N-terminal End
title_sort Differences Between Human and Murine Tau at the N-terminal End
dc.creator.none.fl_str_mv Hernández, Félix
Merchán-Rubira, Jesús
Vallés-Saiz, Laura
Rodríguez-Matellán, Alberto
Ávila, Jesús
author Hernández, Félix
author_facet Hernández, Félix
Merchán-Rubira, Jesús
Vallés-Saiz, Laura
Rodríguez-Matellán, Alberto
Ávila, Jesús
author_role author
author2 Merchán-Rubira, Jesús
Vallés-Saiz, Laura
Rodríguez-Matellán, Alberto
Ávila, Jesús
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Comunidad de Madrid
Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)
Fundación Ramón Areces
Fundación la Caixa
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Alzheimer’s disease
Human tau
Murine tau
Neurodegeneration
Tauopathies
topic Alzheimer’s disease
Human tau
Murine tau
Neurodegeneration
Tauopathies
description Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R isoforms are not present in adult mice. In contrast, the adult human brain contains Tau 3R and also Tau 4R isoforms. In addition, the N-terminal sequence of Tau protein in mice and humans differs, a Tau peptide (residues 17–28) being present in the latter but absent in the former. Here we review the main published data on this N-terminal sequence that suggests that human and mouse Tau proteins interact with different endogenous proteins and also show distinct secretion patterns.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/235843
url http://hdl.handle.net/10261/235843
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3389/fnagi.2020.00011
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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