Combined treatments with photodynamic therapy for non-melanoma skin cancer

Non-melanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population. Among NMSC types, basal cell carcinoma (BCC) has the highest incidence and squamous cell carcinoma (SCC) is less common although it can metastasize, accounting for the majority of NMSC-related deaths. Trea...

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Authors: Lucena, Silvia Rocío, Salazar Ayestarán, Nerea, Gracia Cazaña, Tamara, Zamarrón, Alicia, González, Salvador, Juarranz de la Fuente, Ángeles, Gilaberte, Yolanda
Format: article
Publication Date:2015
Country:España
Institution:Universidad Autónoma de Madrid
Repository:Biblos-e Archivo. Repositorio Institucional de la UAM
Language:English
OAI Identifier:oai:repositorio.uam.es:10486/710141
Online Access:http://hdl.handle.net/10486/710141
https://dx.doi.org/10.3390/ijms161025912
Access Level:Open access
Keyword:Photodynamic therapy
Methyl-aminolevulinic acid
Aminolevulinic acid
Actinic keratosis
Basal cell carcinoma
Bowen disease
Squamous cell carcinoma
Tumor resistance
Biología y Biomedicina / Biología
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spelling Combined treatments with photodynamic therapy for non-melanoma skin cancerLucena, Silvia RocíoSalazar Ayestarán, NereaGracia Cazaña, TamaraZamarrón, AliciaGonzález, SalvadorJuarranz de la Fuente, ÁngelesGilaberte, YolandaPhotodynamic therapyMethyl-aminolevulinic acidAminolevulinic acidActinic keratosisBasal cell carcinomaBowen diseaseSquamous cell carcinomaTumor resistanceBiología y Biomedicina / BiologíaNon-melanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population. Among NMSC types, basal cell carcinoma (BCC) has the highest incidence and squamous cell carcinoma (SCC) is less common although it can metastasize, accounting for the majority of NMSC-related deaths. Treatment options for NMSC include both surgical and non-surgical modalities. Even though surgical approaches are most commonly used to treat these lesions, Photodynamic Therapy (PDT) has the advantage of being a non-invasive option, and capable of field treatment, providing optimum cosmetic outcomes. Numerous clinical research studies have shown the efficacy of PDT for treating pre-malignant and malignant NMSC. However, resistant or recurrent tumors appear and sometimes become more aggressive. In this sense, the enhancement of PDT effectiveness by combining it with other therapeutic modalities has become an interesting field in NMSC research. Depending on the characteristics and the type of tumor, PDT can be applied in combination with immunomodulatory (Imiquimod) and chemotherapeutic (5-fluorouracil, methotrexate, diclofenac, or ingenol mebutate) agents, inhibitors of some molecules implicated in the carcinogenic process (COX2 or MAPK), surgical techniques, or even radiotherapy. These new strategies open the way to a wider improvement of the prevention and eradication of skin cancerThe work has been supported by Spanish MINECO grant FIS PI12/01253 and Comunidad Autónoma de Madrid grant SkinModel CAM S10/BMD-2359. Silvia Lucena and Nerea Salazar were supported by UAM-FPI fellowshipsMDPIDepartamento de BiologíaFacultad de Ciencias20152015-10-28research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/710141https://dx.doi.org/10.3390/ijms161025912reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7101412026-06-23T12:46:27Z
dc.title.none.fl_str_mv Combined treatments with photodynamic therapy for non-melanoma skin cancer
title Combined treatments with photodynamic therapy for non-melanoma skin cancer
spellingShingle Combined treatments with photodynamic therapy for non-melanoma skin cancer
Lucena, Silvia Rocío
Photodynamic therapy
Methyl-aminolevulinic acid
Aminolevulinic acid
Actinic keratosis
Basal cell carcinoma
Bowen disease
Squamous cell carcinoma
Tumor resistance
Biología y Biomedicina / Biología
title_short Combined treatments with photodynamic therapy for non-melanoma skin cancer
title_full Combined treatments with photodynamic therapy for non-melanoma skin cancer
title_fullStr Combined treatments with photodynamic therapy for non-melanoma skin cancer
title_full_unstemmed Combined treatments with photodynamic therapy for non-melanoma skin cancer
title_sort Combined treatments with photodynamic therapy for non-melanoma skin cancer
dc.creator.none.fl_str_mv Lucena, Silvia Rocío
Salazar Ayestarán, Nerea
Gracia Cazaña, Tamara
Zamarrón, Alicia
González, Salvador
Juarranz de la Fuente, Ángeles
Gilaberte, Yolanda
author Lucena, Silvia Rocío
author_facet Lucena, Silvia Rocío
Salazar Ayestarán, Nerea
Gracia Cazaña, Tamara
Zamarrón, Alicia
González, Salvador
Juarranz de la Fuente, Ángeles
Gilaberte, Yolanda
author_role author
author2 Salazar Ayestarán, Nerea
Gracia Cazaña, Tamara
Zamarrón, Alicia
González, Salvador
Juarranz de la Fuente, Ángeles
Gilaberte, Yolanda
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología
Facultad de Ciencias
dc.subject.none.fl_str_mv Photodynamic therapy
Methyl-aminolevulinic acid
Aminolevulinic acid
Actinic keratosis
Basal cell carcinoma
Bowen disease
Squamous cell carcinoma
Tumor resistance
Biología y Biomedicina / Biología
topic Photodynamic therapy
Methyl-aminolevulinic acid
Aminolevulinic acid
Actinic keratosis
Basal cell carcinoma
Bowen disease
Squamous cell carcinoma
Tumor resistance
Biología y Biomedicina / Biología
description Non-melanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population. Among NMSC types, basal cell carcinoma (BCC) has the highest incidence and squamous cell carcinoma (SCC) is less common although it can metastasize, accounting for the majority of NMSC-related deaths. Treatment options for NMSC include both surgical and non-surgical modalities. Even though surgical approaches are most commonly used to treat these lesions, Photodynamic Therapy (PDT) has the advantage of being a non-invasive option, and capable of field treatment, providing optimum cosmetic outcomes. Numerous clinical research studies have shown the efficacy of PDT for treating pre-malignant and malignant NMSC. However, resistant or recurrent tumors appear and sometimes become more aggressive. In this sense, the enhancement of PDT effectiveness by combining it with other therapeutic modalities has become an interesting field in NMSC research. Depending on the characteristics and the type of tumor, PDT can be applied in combination with immunomodulatory (Imiquimod) and chemotherapeutic (5-fluorouracil, methotrexate, diclofenac, or ingenol mebutate) agents, inhibitors of some molecules implicated in the carcinogenic process (COX2 or MAPK), surgical techniques, or even radiotherapy. These new strategies open the way to a wider improvement of the prevention and eradication of skin cancer
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-10-28
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/710141
https://dx.doi.org/10.3390/ijms161025912
url http://hdl.handle.net/10486/710141
https://dx.doi.org/10.3390/ijms161025912
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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