Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort

BACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrog...

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Autores: Iñiguez C, Esplugues A, Sunyer J, Basterrechea M, Fernández-Somoano A, Costa O, Estarlich M, Aguilera I, Lertxundi A, Tardón A, Guxens M, Murcia M, Lopez-Espinosa MJ, Ballester F, INMA Project
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p1187
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/1187
Access Level:acceso abierto
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spelling Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA CohortIñiguez CEsplugues ASunyer JBasterrechea MFernández-Somoano ACosta OEstarlich MAguilera ILertxundi ATardón AGuxens MMurcia MLopez-Espinosa MJBallester FINMA ProjectBACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrogen dioxide (NO2) exposure on fetal and neonatal biometry in the Spanish INMA study. METHODS: Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were evaluated for up to 2,478 fetuses in each trimester of pregnancy. Size at 12, 20, and 34weeks of gestation and growth between these points, as well as anthropometry at birth, were assessed by SD scores derived using cohort-specific growth curves. Temporally adjusted land-use regression was used to estimate exposure to NO2 at home addresses for up to 2,415 fetuses. Associations were investigated by linear regression in each cohort and subsequent meta-analysis. RESULTS: A 10-mu g/m(3) increase in average exposure to NO2 during weeks 0-12 was associated with reduced growth at weeks 0-12 in AC (-2.1%; 95% CI: -3.7, -0.6) and EFW (-1.6%; 95% CI: -3.0, -0.3). The same exposure was inversely associated with reduced growth at weeks 20-34 in BPD (-2.6%; 95% CI: -3.9, -1.2), AC (-1.8%; 95% CI: -3.3, -0.2), and EFW (-2.1%; 95% CI: -3.7, -0.2). A less consistent pattern of association was observed for FL. The negative association of this exposure with BPD and EFW was significantly stronger in smoking versus nonsmoking mothers. CONCLUSIONS: Maternal exposure to NO2 in early pregnancy was associated with reduced fetal growth based on ultrasound measures of growth during pregnancy and measures of size at birth.US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/1187ENVIRONMENTAL HEALTH PERSPECTIVESISSN: 00916765ISSNe: 15529924reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p11872026-06-11T12:45:17Z
dc.title.none.fl_str_mv Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
title Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
spellingShingle Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
Iñiguez C
title_short Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
title_full Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
title_fullStr Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
title_full_unstemmed Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
title_sort Prenatal Exposure to NO<sub>2</sub> and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort
dc.creator.none.fl_str_mv Iñiguez C
Esplugues A
Sunyer J
Basterrechea M
Fernández-Somoano A
Costa O
Estarlich M
Aguilera I
Lertxundi A
Tardón A
Guxens M
Murcia M
Lopez-Espinosa MJ
Ballester F
INMA Project
author Iñiguez C
author_facet Iñiguez C
Esplugues A
Sunyer J
Basterrechea M
Fernández-Somoano A
Costa O
Estarlich M
Aguilera I
Lertxundi A
Tardón A
Guxens M
Murcia M
Lopez-Espinosa MJ
Ballester F
INMA Project
author_role author
author2 Esplugues A
Sunyer J
Basterrechea M
Fernández-Somoano A
Costa O
Estarlich M
Aguilera I
Lertxundi A
Tardón A
Guxens M
Murcia M
Lopez-Espinosa MJ
Ballester F
INMA Project
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
description BACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrogen dioxide (NO2) exposure on fetal and neonatal biometry in the Spanish INMA study. METHODS: Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were evaluated for up to 2,478 fetuses in each trimester of pregnancy. Size at 12, 20, and 34weeks of gestation and growth between these points, as well as anthropometry at birth, were assessed by SD scores derived using cohort-specific growth curves. Temporally adjusted land-use regression was used to estimate exposure to NO2 at home addresses for up to 2,415 fetuses. Associations were investigated by linear regression in each cohort and subsequent meta-analysis. RESULTS: A 10-mu g/m(3) increase in average exposure to NO2 during weeks 0-12 was associated with reduced growth at weeks 0-12 in AC (-2.1%; 95% CI: -3.7, -0.6) and EFW (-1.6%; 95% CI: -3.0, -0.3). The same exposure was inversely associated with reduced growth at weeks 20-34 in BPD (-2.6%; 95% CI: -3.9, -1.2), AC (-1.8%; 95% CI: -3.3, -0.2), and EFW (-2.1%; 95% CI: -3.7, -0.2). A less consistent pattern of association was observed for FL. The negative association of this exposure with BPD and EFW was significantly stronger in smoking versus nonsmoking mothers. CONCLUSIONS: Maternal exposure to NO2 in early pregnancy was associated with reduced fetal growth based on ultrasound measures of growth during pregnancy and measures of size at birth.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/1187
url https://fisabio.portalinvestigacion.com/publicaciones/1187
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
publisher.none.fl_str_mv US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
dc.source.none.fl_str_mv ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN: 00916765
ISSNe: 15529924
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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