Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications

This study describes an innovative apoferritin-based nanohybrid, Apo:[o-COSAN]-, as a high-capacity boron delivery system for potential application in boron neutron capture therapy (BNCT). The nanohybrid is characterized by a high boron content, stability, and the promotion of biological interaction...

Descripción completa

Detalles Bibliográficos
Autores: Alberti, Diego, Piña Marcos, Julieta Nicole, Rakhshan, Sahar, Protti, Nicoletta, Altieri, Saverio, Nuez Martínez, Miquel, Teixidor, Francesc, Viñas, Clara, Geninatti Crich, Simonetta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/394337
Acceso en línea:http://hdl.handle.net/10261/394337
https://api.elsevier.com/content/abstract/scopus_id/105003291535
Access Level:acceso abierto
Palabra clave:Neutron capture therapy
Ferritin
Nanoparticles
id ES_84b35fea5060db4e0859073133003cb5
oai_identifier_str oai:digital.csic.es:10261/394337
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applicationsAlberti, DiegoPiña Marcos, Julieta NicoleRakhshan, SaharProtti, NicolettaAltieri, SaverioNuez Martínez, MiquelTeixidor, FrancescViñas, ClaraGeninatti Crich, SimonettaNeutron capture therapyFerritinNanoparticlesThis study describes an innovative apoferritin-based nanohybrid, Apo:[o-COSAN]-, as a high-capacity boron delivery system for potential application in boron neutron capture therapy (BNCT). The nanohybrid is characterized by a high boron content, stability, and the promotion of biological interactions of cobaltabis(dicarbollide) ([o-COSAN]-), encapsulated within the apoferritin protein cavity through an acid-induced dissociation and reassembly process. The Apo:[o-COSAN]- nanohybrid demonstrated enhanced boron uptake in MCF7 breast cancer and AB22 mesothelioma cell lines, with superior stability and biocompatibility under physiological conditions. Notably, AB22 cells treated with Apo:[o-COSAN]- showed significant cytotoxic effects following neutron irradiation, highlighting the potential of this system in BNCT. These findings underscore the versatility of apoferritin as a multifunctional nanocarrier for targeted cancer therapy, combining high boron payloads with selective tumour cell uptake.We thank AIRC (Associazione italiana per la ricerca sul cancro, project n. 23267 “An innovative Neutron Capture Therapy approach for the treatment of Mesothelioma and diffused thoracic tumour”) and Fondazione San Paolo (bando Trapezio, “Studies for an innovative approach for malignant mesothelioma treatment by radiotherapy for supporting this work”).With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2023-001263-S).Peer reviewedRoyal Society of Chemistry (UK)Associazione Italiana per la Ricerca sul CancroCompagnia di San PaoloAgencia Estatal de Investigación (España)Alberti, Diego [0000-0002-4842-1109]Teixidor, Francesc [0000-0002-3010-2417]Viñas, Clara [0000-0001-5000-0277]Geninatti Crich, Simonetta [0000-0003-2998-5424]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/394337https://api.elsevier.com/content/abstract/scopus_id/105003291535reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2021-2023/CEX2023-001263-SNanoscalehttp://doi.org/10.1039/d5nr00362hSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3943372026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
title Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
spellingShingle Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
Alberti, Diego
Neutron capture therapy
Ferritin
Nanoparticles
title_short Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
title_full Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
title_fullStr Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
title_full_unstemmed Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
title_sort Cobaltabis(dicarbollide) [o-COSAN]- loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
dc.creator.none.fl_str_mv Alberti, Diego
Piña Marcos, Julieta Nicole
Rakhshan, Sahar
Protti, Nicoletta
Altieri, Saverio
Nuez Martínez, Miquel
Teixidor, Francesc
Viñas, Clara
Geninatti Crich, Simonetta
author Alberti, Diego
author_facet Alberti, Diego
Piña Marcos, Julieta Nicole
Rakhshan, Sahar
Protti, Nicoletta
Altieri, Saverio
Nuez Martínez, Miquel
Teixidor, Francesc
Viñas, Clara
Geninatti Crich, Simonetta
author_role author
author2 Piña Marcos, Julieta Nicole
Rakhshan, Sahar
Protti, Nicoletta
Altieri, Saverio
Nuez Martínez, Miquel
Teixidor, Francesc
Viñas, Clara
Geninatti Crich, Simonetta
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Associazione Italiana per la Ricerca sul Cancro
Compagnia di San Paolo
Agencia Estatal de Investigación (España)
Alberti, Diego [0000-0002-4842-1109]
Teixidor, Francesc [0000-0002-3010-2417]
Viñas, Clara [0000-0001-5000-0277]
Geninatti Crich, Simonetta [0000-0003-2998-5424]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Neutron capture therapy
Ferritin
Nanoparticles
topic Neutron capture therapy
Ferritin
Nanoparticles
description This study describes an innovative apoferritin-based nanohybrid, Apo:[o-COSAN]-, as a high-capacity boron delivery system for potential application in boron neutron capture therapy (BNCT). The nanohybrid is characterized by a high boron content, stability, and the promotion of biological interactions of cobaltabis(dicarbollide) ([o-COSAN]-), encapsulated within the apoferritin protein cavity through an acid-induced dissociation and reassembly process. The Apo:[o-COSAN]- nanohybrid demonstrated enhanced boron uptake in MCF7 breast cancer and AB22 mesothelioma cell lines, with superior stability and biocompatibility under physiological conditions. Notably, AB22 cells treated with Apo:[o-COSAN]- showed significant cytotoxic effects following neutron irradiation, highlighting the potential of this system in BNCT. These findings underscore the versatility of apoferritin as a multifunctional nanocarrier for targeted cancer therapy, combining high boron payloads with selective tumour cell uptake.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/394337
https://api.elsevier.com/content/abstract/scopus_id/105003291535
url http://hdl.handle.net/10261/394337
https://api.elsevier.com/content/abstract/scopus_id/105003291535
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2021-2023/CEX2023-001263-S
Nanoscale
http://doi.org/10.1039/d5nr00362h
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412243927465984
score 15,81155

Similares en LA Referencia