Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial
Biomarkers; Hormone receptor-positive; Advanced breast cancer
| Authors: | , , , , , |
|---|---|
| Format: | article |
| Status: | Published version |
| Publication Date: | 2025 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/13527 |
| Online Access: | http://hdl.handle.net/11351/13527 |
| Access Level: | Open access |
| Keyword: | Marcadors bioquímics Proteïnes quinases - Inhibidors - Ús terapèutic Mama - Càncer - Tractament Quimioteràpia combinada CHEMICALS AND DRUGS::Biological Factors::Biomarkers CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::/therapeutic use DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada |
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Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trialArteaga, CarlosRojo, FedericoGonzalez-Perez, AbelAlbanell, JoanGamez-Pozo, AngeloBellet Ezquerra, MeritxellMarcadors bioquímicsProteïnes quinases - Inhibidors - Ús terapèuticMama - Càncer - TractamentQuimioteràpia combinadaCHEMICALS AND DRUGS::Biological Factors::BiomarkersCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase InhibitorsOther subheadings::Other subheadings::/therapeutic useDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsOther subheadings::Other subheadings::Other subheadings::/drug therapyANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy ProtocolsCOMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadoresCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasasOtros calificadores::Otros calificadores::/uso terapéuticoENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinadaBiomarkers; Hormone receptor-positive; Advanced breast cancerBiomarcadores; Cáncer de mama avanzado; Receptor hormonal positivoBiomarcadors; Càncer de mama avançat; Receptor hormonal positiuCurrently, there are no clinically actionable biomarkers to predict patient to cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) plus endocrine therapy for hormone receptor (HR)[+]/ human epidermal growth factor receptor 2 (HER2)[-] advanced breast cancer (ABC). Herein, we report an exploratory biomarker substudy (transFAL) from a subset of patients included in PARSIFAL, a phase II randomized clinical trial that evaluated first-line palbociclib plus fulvestrant or letrozole for HR[+]/HER2[−] ABC. No definitive biomarkers were discovered, however, worse outcomes were found with CDK6 postivity (p = 0.008), ER negativity (p = 0.008), high Ki67 (p = 0.04), and TP53 mutation (p = 0.04). ctDNA density (p = 0.036) and number of mutations (p = 0.033) at baseline were significantly higher for resistant patients. Our study reveals future directions to explore in the goal to determine biomarkers of response to CDK4/6i.Nature PortfolioInstitut Català de la Salut[Albanell J] Hospital del Mar Research Institute Barcelona, Depatment of Medical Oncology, Hospital del Mar, Barcelona, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Centro de Investigación Biomédica en Red de Oncología (CIBERONC-ISCIII), Madrid, Spain. [Gámez Pozo A] Translational Oncology Lab, University Hospital La Paz - IdiPAZ, Madrid, Spain. [Arteaga CL] UT Southwestern Simmons Comprehensive Cancer Center, Dallas, TX, USA. [Bellet M] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Rojo F, González A] Hospital del Mar Research Institute Barcelona, Depatment of Medical Oncology, Hospital del Mar, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13527http://hdl.handle.net/11351/13527Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésnpj Breast Cancer;11https://doi.org/10.1038/s41523-025-00777-0Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/135272026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial |
| title |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial |
| spellingShingle |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial Arteaga, Carlos Marcadors bioquímics Proteïnes quinases - Inhibidors - Ús terapèutic Mama - Càncer - Tractament Quimioteràpia combinada CHEMICALS AND DRUGS::Biological Factors::Biomarkers CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::/therapeutic use DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada |
| title_short |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial |
| title_full |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial |
| title_fullStr |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial |
| title_full_unstemmed |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial |
| title_sort |
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial |
| dc.creator.none.fl_str_mv |
Arteaga, Carlos Rojo, Federico Gonzalez-Perez, Abel Albanell, Joan Gamez-Pozo, Angelo Bellet Ezquerra, Meritxell |
| author |
Arteaga, Carlos |
| author_facet |
Arteaga, Carlos Rojo, Federico Gonzalez-Perez, Abel Albanell, Joan Gamez-Pozo, Angelo Bellet Ezquerra, Meritxell |
| author_role |
author |
| author2 |
Rojo, Federico Gonzalez-Perez, Abel Albanell, Joan Gamez-Pozo, Angelo Bellet Ezquerra, Meritxell |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Albanell J] Hospital del Mar Research Institute Barcelona, Depatment of Medical Oncology, Hospital del Mar, Barcelona, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Centro de Investigación Biomédica en Red de Oncología (CIBERONC-ISCIII), Madrid, Spain. [Gámez Pozo A] Translational Oncology Lab, University Hospital La Paz - IdiPAZ, Madrid, Spain. [Arteaga CL] UT Southwestern Simmons Comprehensive Cancer Center, Dallas, TX, USA. [Bellet M] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Rojo F, González A] Hospital del Mar Research Institute Barcelona, Depatment of Medical Oncology, Hospital del Mar, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Marcadors bioquímics Proteïnes quinases - Inhibidors - Ús terapèutic Mama - Càncer - Tractament Quimioteràpia combinada CHEMICALS AND DRUGS::Biological Factors::Biomarkers CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::/therapeutic use DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada |
| topic |
Marcadors bioquímics Proteïnes quinases - Inhibidors - Ús terapèutic Mama - Càncer - Tractament Quimioteràpia combinada CHEMICALS AND DRUGS::Biological Factors::Biomarkers CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::/therapeutic use DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada |
| description |
Biomarkers; Hormone receptor-positive; Advanced breast cancer |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/11351/13527 http://hdl.handle.net/11351/13527 |
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http://hdl.handle.net/11351/13527 |
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Inglés |
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Inglés |
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npj Breast Cancer;11 https://doi.org/10.1038/s41523-025-00777-0 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Nature Portfolio |
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Nature Portfolio |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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