Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery

Osteoporotic hip fracture (OHF) is an increasingly frequent age-related pathology, which results in high rates of functional loss and mortality within the first year after surgery. This study assessed whether preoperative levels of brain natriuretic peptide (NT-proBNP) and troponin I were related to...

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Autores: Araguas, M.A., Herrera, A., Garrido, I., Mateo, J., Mayoral, A.P., Muñoz, M.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:101535
Acceso en línea:http://zaguan.unizar.es/record/101535
Access Level:acceso abierto
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spelling Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgeryAraguas, M.A.Herrera, A.Garrido, I.Mateo, J.Mayoral, A.P.Muñoz, M.Osteoporotic hip fracture (OHF) is an increasingly frequent age-related pathology, which results in high rates of functional loss and mortality within the first year after surgery. This study assessed whether preoperative levels of brain natriuretic peptide (NT-proBNP) and troponin I were related to early occurrence (30d) of major adverse cardio-vascular events (MACE) after OHF repair surgery. During a 6-month period, perioperative clinical and analytical data from consecutive patients, without known history of cardiovascular disease and undergoing surgery for OHF repair at a single centre, were prospectively collected. MACE was defined as acute myocardial ischaemia or infarction, acute heart failure or cardiovascular death. amongst the 140 patients included, 23 (16.4%) developed postoperative MACE (MACE group) and 117 did not (Control group). Compared to those from control group, patients from MACE group were older, had poorer physical status (ASA III–IV), received preoperative red blood cell transfusion (RBCT) more frequently, presented with lower haemoglobin concentrations and higher NT-proBNP, creatinine and troponin I concentrations. Overall, RBCT requirements and 30d mortality rate were also higher in MACE group. However, in multivariate analysis, only preoperative RBCT, creatinine >1 mg/dL and NT-proBNP >450 pg/mL remained as independent preoperative risks factors for postoperative MACE, while 95% confidence intervals of odds ratios were wide. Though our findings require confirmation in a larger multicentre cohort, identifying risk factors for early postoperative MACE after OHF repair surgery, might facilitate assessing patients’ risk prior to and following surgery, and targeting them the appropriate preventive and/or therapeutic interventions.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://zaguan.unizar.es/record/101535reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/MINECO/DPI2016-77745-Rinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1015352026-05-29T13:59:51Z
dc.title.none.fl_str_mv Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
title Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
spellingShingle Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
Araguas, M.A.
title_short Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
title_full Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
title_fullStr Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
title_full_unstemmed Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
title_sort Risk factors for major adverse cardiovascular events after osteoporotic hip fracture repair surgery
dc.creator.none.fl_str_mv Araguas, M.A.
Herrera, A.
Garrido, I.
Mateo, J.
Mayoral, A.P.
Muñoz, M.
author Araguas, M.A.
author_facet Araguas, M.A.
Herrera, A.
Garrido, I.
Mateo, J.
Mayoral, A.P.
Muñoz, M.
author_role author
author2 Herrera, A.
Garrido, I.
Mateo, J.
Mayoral, A.P.
Muñoz, M.
author2_role author
author
author
author
author
description Osteoporotic hip fracture (OHF) is an increasingly frequent age-related pathology, which results in high rates of functional loss and mortality within the first year after surgery. This study assessed whether preoperative levels of brain natriuretic peptide (NT-proBNP) and troponin I were related to early occurrence (30d) of major adverse cardio-vascular events (MACE) after OHF repair surgery. During a 6-month period, perioperative clinical and analytical data from consecutive patients, without known history of cardiovascular disease and undergoing surgery for OHF repair at a single centre, were prospectively collected. MACE was defined as acute myocardial ischaemia or infarction, acute heart failure or cardiovascular death. amongst the 140 patients included, 23 (16.4%) developed postoperative MACE (MACE group) and 117 did not (Control group). Compared to those from control group, patients from MACE group were older, had poorer physical status (ASA III–IV), received preoperative red blood cell transfusion (RBCT) more frequently, presented with lower haemoglobin concentrations and higher NT-proBNP, creatinine and troponin I concentrations. Overall, RBCT requirements and 30d mortality rate were also higher in MACE group. However, in multivariate analysis, only preoperative RBCT, creatinine >1 mg/dL and NT-proBNP >450 pg/mL remained as independent preoperative risks factors for postoperative MACE, while 95% confidence intervals of odds ratios were wide. Though our findings require confirmation in a larger multicentre cohort, identifying risk factors for early postoperative MACE after OHF repair surgery, might facilitate assessing patients’ risk prior to and following surgery, and targeting them the appropriate preventive and/or therapeutic interventions.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
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dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/101535
url http://zaguan.unizar.es/record/101535
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/MINECO/DPI2016-77745-R
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
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publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
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