Liposomal cytarabine for the treatment of leptomeningeal dissemination of central nervous system tumours in children and adolescents
Leptomeningeal dissemination in paediatric central nervous system (CNS) tumours is associated with a poor outcome, and new therapeutic strategies are desperately needed. One of the main difficulties in the treatment of CNS tumours is blood brain barrier penetration. Intrathecal therapy has shown to...
| Autores: | , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Recursos: | Fundació Sant Joan de Déu |
| Repositorio: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:fsjd.fundanetsuite.com:p9651 |
| Acesso em linha: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9651 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964328459&doi=10.1016%2fj.anpedi.2016.02.007&partnerID=40&md5=c3e4f73055723a5d7d39238f162d2332 |
| Access Level: | acceso abierto |
| Palavra-chave: | Central nervous system tumours, Citarabina liposomal, Diseminación leptomeníngea, Ependimoma, Ependymoma, Intratecal, Intrathecal, Leptomeningeal dissemination, Liposomal cytarabine, Medulloblastoma, Meduloblastoma, Tumores del sistema nervioso central |
| Resumo: | Leptomeningeal dissemination in paediatric central nervous system (CNS) tumours is associated with a poor outcome, and new therapeutic strategies are desperately needed. One of the main difficulties in the treatment of CNS tumours is blood brain barrier penetration. Intrathecal therapy has shown to be effective in several paediatric tumours. The aim of this article is to review the data available on the use of liposomal cytarabine for paediatric patients with leptomeningeal dissemination of CNS tumours, including the pharmacology, administration route, safety and efficacy data. |
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