Mitochondrial DNA deletions in the cerebrospinal fluid of patients with idiopathic REM sleep behaviour disorder

Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) represents the prodromal stage of Lewy body disorders (Parkinson's disease (PD) and dementia with Lewy bodies (DLB)) which are linked to variations in circulating cell-free mitochondrial DNA (cf-mtDNA). Here, we assessed whethe...

Descripción completa

Detalles Bibliográficos
Autores: Puigros Serra, Margalida, Calderón, Anna, Martín-Ruiz, Daniel, Serradell, Mònica, Fernández Ortiga, Manel, Muñoz-Lopetegi, Amaia, Mayà, Gerard, Santamaria, Joan, Gaig, Carles, Colell Riera, Anna, Tolosa, Eduardo, Iranzo, Alex, Trullas, Ramón
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/366002
Acceso en línea:http://hdl.handle.net/10261/366002
https://api.elsevier.com/content/abstract/scopus_id/85188124635
Access Level:acceso abierto
Palabra clave:Dementia with Lewy bodies
Digital PCR
Idiopathic REM sleep behaviour disorder
Mitochondrial DNA
Parkinson's disease
Descripción
Sumario:Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) represents the prodromal stage of Lewy body disorders (Parkinson's disease (PD) and dementia with Lewy bodies (DLB)) which are linked to variations in circulating cell-free mitochondrial DNA (cf-mtDNA). Here, we assessed whether altered cf-mtDNA release and integrity are already present in IRBD.

Similares en LA Referencia