A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma

Patients with a first episode psychosis (FEP) who are admitted for the first time to a psychiatric hospital frequently have experienced prior psychological trauma. Additionally, 40-80% develop posttraumatic stress symptoms, which are summarized as a post-psychotic post-traumatic syndrome (PPS). Eye...

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Autores: Valiente Gomez, Alicia|||0000-0003-0220-2397, Pujol, Nuria, Moreno Alcázar, Ana|||0000-0002-3392-5590, Radua, Joaquim|||0000-0003-1240-5438, Monteagudo-Gimeno, Eila|||0000-0002-8301-9406, Gardoki-Souto, Itxaso|||0000-0002-0775-1275, Hogg, Bridget|||0000-0002-2405-0593, Álvarez Alonso, Maria José, Safont, Gemma|||0000-0001-5122-9161, Lupo, Walter, Pérez Solà, Víctor|||0000-0002-5825-2337, Amann, Benedikt L.|||0000-0002-4407-1519
Tipo de documento: artigo
Data de publicação:2020
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:252479
Acesso em linha:https://ddd.uab.cat/record/252479
https://dx.doi.org/urn:doi:10.3389/fpsyt.2019.01023
Access Level:Acceso aberto
Palavra-chave:First episode psychosis
Psychological trauma
Post-psychotic posttraumatic stress
Comorbidity
EMDR therapy
Treatment as usual
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spelling A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological TraumaA Protocol DesignValiente Gomez, Alicia|||0000-0003-0220-2397Pujol, NuriaMoreno Alcázar, Ana|||0000-0002-3392-5590Radua, Joaquim|||0000-0003-1240-5438Monteagudo-Gimeno, Eila|||0000-0002-8301-9406Gardoki-Souto, Itxaso|||0000-0002-0775-1275Hogg, Bridget|||0000-0002-2405-0593Álvarez Alonso, Maria JoséSafont, Gemma|||0000-0001-5122-9161Lupo, WalterPérez Solà, Víctor|||0000-0002-5825-2337Amann, Benedikt L.|||0000-0002-4407-1519First episode psychosisPsychological traumaPost-psychotic posttraumatic stressComorbidityEMDR therapyTreatment as usualPatients with a first episode psychosis (FEP) who are admitted for the first time to a psychiatric hospital frequently have experienced prior psychological trauma. Additionally, 40-80% develop posttraumatic stress symptoms, which are summarized as a post-psychotic post-traumatic syndrome (PPS). Eye Movement Desensitization and reprocessing (EMDR) therapy could be an effective psychotherapy to treat a PPS and prior psychological traumas in this population. To assess if EMDR therapy leads to: 1) a reduction of relapses after intervention, 2) an improvement of trauma-related, psychotic and affective symptoms, 3) an improvement of overall functioning, and 4) an improvement in quality of life. This is a multicenter phase II rater-blinded randomized controlled trial in which 80 FEP patients with a history of psychological trauma will be randomly assigned to EMDR (n = 40) or to TAU (n = 40). Traumatic events will be measured by the Global Assessment of Posttraumatic Stress Questionnaire, the Cumulative Trauma Screening, the Impact of Event Scale-Revised, the Dissociative Experiences Scale, the Childhood Trauma Scale, the Holmes-Rahe Life Stress Inventory, and the Dissociative Experiences Questionnaire. Clinical symptomatology will be evaluated using the Suicide and Drug Consumption module of the International Neuropsychiatric Interview, Structured Clinical Interview for Positive and Negative Syndrome Scale, Young's Scale for Mania Evaluation, and Beck Depression II Questionnaire. Functionality will be assessed with the Global Assessment of Functioning and the Quality of Life with the Standardized Instrument developed by the EuroQol Group. The cognitive insight and adherence to the treatment will be assessed with the Beck Cognitive Insight Scale and the Drug Attitude Inventory. All variables will be measured at baseline, post-treatment and at 12-month follow-up. This study will provide evidence of whether EMDR therapy is effective in reducing trauma and clinical symptoms, reducing relapses and in improving functionality and quality of life in patients with FEP and a history of trauma. , identifier: NCT03991377. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252479https://dx.doi.org/urn:doi:10.3389/fpsyt.2019.01023reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00009open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2524792026-06-06T12:50:31Z
dc.title.none.fl_str_mv A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
A Protocol Design
title A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
spellingShingle A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
Valiente Gomez, Alicia|||0000-0003-0220-2397
First episode psychosis
Psychological trauma
Post-psychotic posttraumatic stress
Comorbidity
EMDR therapy
Treatment as usual
title_short A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
title_full A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
title_fullStr A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
title_full_unstemmed A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
title_sort A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma
dc.creator.none.fl_str_mv Valiente Gomez, Alicia|||0000-0003-0220-2397
Pujol, Nuria
Moreno Alcázar, Ana|||0000-0002-3392-5590
Radua, Joaquim|||0000-0003-1240-5438
Monteagudo-Gimeno, Eila|||0000-0002-8301-9406
Gardoki-Souto, Itxaso|||0000-0002-0775-1275
Hogg, Bridget|||0000-0002-2405-0593
Álvarez Alonso, Maria José
Safont, Gemma|||0000-0001-5122-9161
Lupo, Walter
Pérez Solà, Víctor|||0000-0002-5825-2337
Amann, Benedikt L.|||0000-0002-4407-1519
author Valiente Gomez, Alicia|||0000-0003-0220-2397
author_facet Valiente Gomez, Alicia|||0000-0003-0220-2397
Pujol, Nuria
Moreno Alcázar, Ana|||0000-0002-3392-5590
Radua, Joaquim|||0000-0003-1240-5438
Monteagudo-Gimeno, Eila|||0000-0002-8301-9406
Gardoki-Souto, Itxaso|||0000-0002-0775-1275
Hogg, Bridget|||0000-0002-2405-0593
Álvarez Alonso, Maria José
Safont, Gemma|||0000-0001-5122-9161
Lupo, Walter
Pérez Solà, Víctor|||0000-0002-5825-2337
Amann, Benedikt L.|||0000-0002-4407-1519
author_role author
author2 Pujol, Nuria
Moreno Alcázar, Ana|||0000-0002-3392-5590
Radua, Joaquim|||0000-0003-1240-5438
Monteagudo-Gimeno, Eila|||0000-0002-8301-9406
Gardoki-Souto, Itxaso|||0000-0002-0775-1275
Hogg, Bridget|||0000-0002-2405-0593
Álvarez Alonso, Maria José
Safont, Gemma|||0000-0001-5122-9161
Lupo, Walter
Pérez Solà, Víctor|||0000-0002-5825-2337
Amann, Benedikt L.|||0000-0002-4407-1519
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv First episode psychosis
Psychological trauma
Post-psychotic posttraumatic stress
Comorbidity
EMDR therapy
Treatment as usual
topic First episode psychosis
Psychological trauma
Post-psychotic posttraumatic stress
Comorbidity
EMDR therapy
Treatment as usual
description Patients with a first episode psychosis (FEP) who are admitted for the first time to a psychiatric hospital frequently have experienced prior psychological trauma. Additionally, 40-80% develop posttraumatic stress symptoms, which are summarized as a post-psychotic post-traumatic syndrome (PPS). Eye Movement Desensitization and reprocessing (EMDR) therapy could be an effective psychotherapy to treat a PPS and prior psychological traumas in this population. To assess if EMDR therapy leads to: 1) a reduction of relapses after intervention, 2) an improvement of trauma-related, psychotic and affective symptoms, 3) an improvement of overall functioning, and 4) an improvement in quality of life. This is a multicenter phase II rater-blinded randomized controlled trial in which 80 FEP patients with a history of psychological trauma will be randomly assigned to EMDR (n = 40) or to TAU (n = 40). Traumatic events will be measured by the Global Assessment of Posttraumatic Stress Questionnaire, the Cumulative Trauma Screening, the Impact of Event Scale-Revised, the Dissociative Experiences Scale, the Childhood Trauma Scale, the Holmes-Rahe Life Stress Inventory, and the Dissociative Experiences Questionnaire. Clinical symptomatology will be evaluated using the Suicide and Drug Consumption module of the International Neuropsychiatric Interview, Structured Clinical Interview for Positive and Negative Syndrome Scale, Young's Scale for Mania Evaluation, and Beck Depression II Questionnaire. Functionality will be assessed with the Global Assessment of Functioning and the Quality of Life with the Standardized Instrument developed by the EuroQol Group. The cognitive insight and adherence to the treatment will be assessed with the Beck Cognitive Insight Scale and the Drug Attitude Inventory. All variables will be measured at baseline, post-treatment and at 12-month follow-up. This study will provide evidence of whether EMDR therapy is effective in reducing trauma and clinical symptoms, reducing relapses and in improving functionality and quality of life in patients with FEP and a history of trauma. , identifier: NCT03991377.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/252479
https://dx.doi.org/urn:doi:10.3389/fpsyt.2019.01023
url https://ddd.uab.cat/record/252479
https://dx.doi.org/urn:doi:10.3389/fpsyt.2019.01023
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00009
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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