Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques

Background/Aims: Ruthenium plaques are used for the treatment of ocular tumors. The aim of this work is the comparison between simulated absorbed dose distributions tallied in an anthropomorphic phantom, obtained from ideal homogeneous plaques, and real eye plaques in which the actual heterogeneous...

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Autores: Zaragoza Serrano, Francisco José|||0000-0001-5973-156X, Eichmann, M., Flühs, D.
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/177416
Acceso en línea:https://hdl.handle.net/2117/177416
https://dx.doi.org/10.1159/000492599
Access Level:acceso abierto
Palabra clave:Monte Carlo method
Eye--Diseases
Uvea
Monte Carlo simulation
Brachytherapy
PENELOPE
Ruthenium
Eye plaques
Beta emitter
Treatment planning
Uveal melanoma
Montecarlo, Mètode de
Ulls--Malalties
Úvea
Àrees temàtiques de la UPC::Física
Àrees temàtiques de la UPC::Ciències de la visió
Àrees temàtiques de la UPC::Enginyeria biomèdica
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spelling Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaquesZaragoza Serrano, Francisco José|||0000-0001-5973-156XEichmann, M.Flühs, D.Monte Carlo methodEye--DiseasesUveaMonte Carlo simulationBrachytherapyPENELOPERutheniumEye plaquesBeta emitterTreatment planningUveal melanomaMontecarlo, Mètode deUlls--MalaltiesÚveaÀrees temàtiques de la UPC::FísicaÀrees temàtiques de la UPC::Ciències de la visióÀrees temàtiques de la UPC::Enginyeria biomèdicaBackground/Aims: Ruthenium plaques are used for the treatment of ocular tumors. The aim of this work is the comparison between simulated absorbed dose distributions tallied in an anthropomorphic phantom, obtained from ideal homogeneous plaques, and real eye plaques in which the actual heterogeneous distribution of 106Ru was measured. The placement of the plaques with respect to the tumor location was taken into consideration to optimize the effectiveness of the treatment. Methods: The generic CCA and CCB, and the specific CCA1364 and CCB1256 106Ru eye plaques were modeled with the Monte Carlo code PENELOPE. To compare the suitability of each treatment for an anterior, equatorial and posterior tumor location, cumulative dose-volume histograms for the tumors and structures at risk were calculated. Results: Eccentric placements of the plaques, taking into account the inhomogeneities of the emitter map, can substantially reduce the dose delivered to structures at risk while maintaining the prescribed dose at the tumor apex. Conclusions: The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures. © 2018 S. Karger AG, Basel20192019-06-0120202020-02-11journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/177416https://dx.doi.org/10.1159/000492599reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1774162026-05-27T15:37:01Z
dc.title.none.fl_str_mv Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
title Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
spellingShingle Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
Zaragoza Serrano, Francisco José|||0000-0001-5973-156X
Monte Carlo method
Eye--Diseases
Uvea
Monte Carlo simulation
Brachytherapy
PENELOPE
Ruthenium
Eye plaques
Beta emitter
Treatment planning
Uveal melanoma
Montecarlo, Mètode de
Ulls--Malalties
Úvea
Àrees temàtiques de la UPC::Física
Àrees temàtiques de la UPC::Ciències de la visió
Àrees temàtiques de la UPC::Enginyeria biomèdica
title_short Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
title_full Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
title_fullStr Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
title_full_unstemmed Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
title_sort Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques
dc.creator.none.fl_str_mv Zaragoza Serrano, Francisco José|||0000-0001-5973-156X
Eichmann, M.
Flühs, D.
author Zaragoza Serrano, Francisco José|||0000-0001-5973-156X
author_facet Zaragoza Serrano, Francisco José|||0000-0001-5973-156X
Eichmann, M.
Flühs, D.
author_role author
author2 Eichmann, M.
Flühs, D.
author2_role author
author
dc.subject.none.fl_str_mv Monte Carlo method
Eye--Diseases
Uvea
Monte Carlo simulation
Brachytherapy
PENELOPE
Ruthenium
Eye plaques
Beta emitter
Treatment planning
Uveal melanoma
Montecarlo, Mètode de
Ulls--Malalties
Úvea
Àrees temàtiques de la UPC::Física
Àrees temàtiques de la UPC::Ciències de la visió
Àrees temàtiques de la UPC::Enginyeria biomèdica
topic Monte Carlo method
Eye--Diseases
Uvea
Monte Carlo simulation
Brachytherapy
PENELOPE
Ruthenium
Eye plaques
Beta emitter
Treatment planning
Uveal melanoma
Montecarlo, Mètode de
Ulls--Malalties
Úvea
Àrees temàtiques de la UPC::Física
Àrees temàtiques de la UPC::Ciències de la visió
Àrees temàtiques de la UPC::Enginyeria biomèdica
description Background/Aims: Ruthenium plaques are used for the treatment of ocular tumors. The aim of this work is the comparison between simulated absorbed dose distributions tallied in an anthropomorphic phantom, obtained from ideal homogeneous plaques, and real eye plaques in which the actual heterogeneous distribution of 106Ru was measured. The placement of the plaques with respect to the tumor location was taken into consideration to optimize the effectiveness of the treatment. Methods: The generic CCA and CCB, and the specific CCA1364 and CCB1256 106Ru eye plaques were modeled with the Monte Carlo code PENELOPE. To compare the suitability of each treatment for an anterior, equatorial and posterior tumor location, cumulative dose-volume histograms for the tumors and structures at risk were calculated. Results: Eccentric placements of the plaques, taking into account the inhomogeneities of the emitter map, can substantially reduce the dose delivered to structures at risk while maintaining the prescribed dose at the tumor apex. Conclusions: The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures. © 2018 S. Karger AG, Basel
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-06-01
2020
2020-02-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/177416
https://dx.doi.org/10.1159/000492599
url https://hdl.handle.net/2117/177416
https://dx.doi.org/10.1159/000492599
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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