Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage

Asla Roca, Queralt|||0000-0001-6049-8048; Garrido, M.; Urgell, Eulàlia|||0000-0003-3519-1022; Terzan, S.; Santos, Alicia|||0000-0002-2179-6189; Fernández, M.; Varghese, N.; Atila, C.; Calabrese, A.; Biagetti, Betina|||0000-0002-8837-4343; Plessow, F.; Gich, Ignasi|||0000-0003-3975-6588; Christ-Crain, Mirjam|||0000-0002-6336-0965; Eckert, A.; Webb, S. M.|||0000-0001-7052-6436; Lawson, E.A.; Aulinas, Anna|||0000-0002-1205-7114

Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage

Increasing evidence supports the presence of oxytocin deficiency (OXT-D) in patients with hypopituitarism and hypothalamic damage (HHD), that might be associated with neuropsychological deficits and sexual dysfunction, leading to worse quality of life (QoL). Therefore, identifying a provocative test...

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Autores:	Asla Roca, Queralt\|\|\|0000-0001-6049-8048, Garrido, M., Urgell, Eulàlia\|\|\|0000-0003-3519-1022, Terzan, S., Santos, Alicia\|\|\|0000-0002-2179-6189, Fernández, M., Varghese, N., Atila, C., Calabrese, A., Biagetti, Betina\|\|\|0000-0002-8837-4343, Plessow, F., Gich, Ignasi\|\|\|0000-0003-3975-6588, Christ-Crain, Mirjam\|\|\|0000-0002-6336-0965, Eckert, A., Webb, S. M.\|\|\|0000-0001-7052-6436, Lawson, E.A., Aulinas, Anna\|\|\|0000-0002-1205-7114
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:320380
Acceso en línea:	https://ddd.uab.cat/record/320380 https://dx.doi.org/urn:doi:10.1038/s41598-025-86566-y
Access Level:	acceso abierto
Palabra clave:	Arginine-vasopressin deficiency Corticotropin-releasing hormone Hypopituitarism Hypothalamic damage Oxytocin Pituitary disease

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spelling	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damagea randomized, crossover, placebo-controlled trialAsla Roca, Queralt\|\|\|0000-0001-6049-8048Garrido, M.Urgell, Eulàlia\|\|\|0000-0003-3519-1022Terzan, S.Santos, Alicia\|\|\|0000-0002-2179-6189Fernández, M.Varghese, N.Atila, C.Calabrese, A.Biagetti, Betina\|\|\|0000-0002-8837-4343Plessow, F.Gich, Ignasi\|\|\|0000-0003-3975-6588Christ-Crain, Mirjam\|\|\|0000-0002-6336-0965Eckert, A.Webb, S. M.\|\|\|0000-0001-7052-6436Lawson, E.A.Aulinas, Anna\|\|\|0000-0002-1205-7114Arginine-vasopressin deficiencyCorticotropin-releasing hormoneHypopituitarismHypothalamic damageOxytocinPituitary diseaseIncreasing evidence supports the presence of oxytocin deficiency (OXT-D) in patients with hypopituitarism and hypothalamic damage (HHD), that might be associated with neuropsychological deficits and sexual dysfunction, leading to worse quality of life (QoL). Therefore, identifying a provocative test to diagnose an OXT-D will be important. Corticotropin-releasing hormone (CRH) is a candidate for such a test as it increases oxytocin secretion in animal models. This study aimed to examine the effects of CRH on oxytocin release in HHD compared to healthy controls (HC) and to describe the psychopathology, sexual function and QoL and their associations with oxytocin. This is a single-blind, randomized, placebo-controlled, proof-of-concept study (NCT 04902235) with crossover assignment (CRH vs. placebo). Nineteen HHD patients (10 females) and 20 HC (11 females) completed two visits, receiving CRH or placebo in random order and completed validated questionnaires to assess psychopathology, sexual function and QoL. Samples were collected over 120 min to assess oxytocin. Linear mixed-effects regression model evaluated the change in oxytocin after CRH/placebo in HHD vs. HC. CRH administration did not impact oxytocin concentrations across groups over time (p = 0.97). HHD had greater psychopathology (most ps < 0.05), sexual dysfunction (p < 0.03) and worse QoL (p < 0.001) compared to HC, nevertheless, baseline oxytocin concentrations and area under the curve of oxytocin were not significantly associated with psychopathology, sexual function or QoL, neither in HHD or HC. In conclusion, CRH administration does not appear to be a suitable provocative test for diagnosing OXT-D in HHD. Identifying a reliable diagnostic test for OXT-D remains crucial. Alternative provocative tests or biomarkers should be explored. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/320380https://dx.doi.org/urn:doi:10.1038/s41598-025-86566-yreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01165open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3203802026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage a randomized, crossover, placebo-controlled trial
title	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage
spellingShingle	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage Asla Roca, Queralt\|\|\|0000-0001-6049-8048 Arginine-vasopressin deficiency Corticotropin-releasing hormone Hypopituitarism Hypothalamic damage Oxytocin Pituitary disease
title_short	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage
title_full	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage
title_fullStr	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage
title_full_unstemmed	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage
title_sort	Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage
dc.creator.none.fl_str_mv	Asla Roca, Queralt\|\|\|0000-0001-6049-8048 Garrido, M. Urgell, Eulàlia\|\|\|0000-0003-3519-1022 Terzan, S. Santos, Alicia\|\|\|0000-0002-2179-6189 Fernández, M. Varghese, N. Atila, C. Calabrese, A. Biagetti, Betina\|\|\|0000-0002-8837-4343 Plessow, F. Gich, Ignasi\|\|\|0000-0003-3975-6588 Christ-Crain, Mirjam\|\|\|0000-0002-6336-0965 Eckert, A. Webb, S. M.\|\|\|0000-0001-7052-6436 Lawson, E.A. Aulinas, Anna\|\|\|0000-0002-1205-7114
author	Asla Roca, Queralt\|\|\|0000-0001-6049-8048
author_facet	Asla Roca, Queralt\|\|\|0000-0001-6049-8048 Garrido, M. Urgell, Eulàlia\|\|\|0000-0003-3519-1022 Terzan, S. Santos, Alicia\|\|\|0000-0002-2179-6189 Fernández, M. Varghese, N. Atila, C. Calabrese, A. Biagetti, Betina\|\|\|0000-0002-8837-4343 Plessow, F. Gich, Ignasi\|\|\|0000-0003-3975-6588 Christ-Crain, Mirjam\|\|\|0000-0002-6336-0965 Eckert, A. Webb, S. M.\|\|\|0000-0001-7052-6436 Lawson, E.A. Aulinas, Anna\|\|\|0000-0002-1205-7114
author_role	author
author2	Garrido, M. Urgell, Eulàlia\|\|\|0000-0003-3519-1022 Terzan, S. Santos, Alicia\|\|\|0000-0002-2179-6189 Fernández, M. Varghese, N. Atila, C. Calabrese, A. Biagetti, Betina\|\|\|0000-0002-8837-4343 Plessow, F. Gich, Ignasi\|\|\|0000-0003-3975-6588 Christ-Crain, Mirjam\|\|\|0000-0002-6336-0965 Eckert, A. Webb, S. M.\|\|\|0000-0001-7052-6436 Lawson, E.A. Aulinas, Anna\|\|\|0000-0002-1205-7114
author2_role	author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Arginine-vasopressin deficiency Corticotropin-releasing hormone Hypopituitarism Hypothalamic damage Oxytocin Pituitary disease
topic	Arginine-vasopressin deficiency Corticotropin-releasing hormone Hypopituitarism Hypothalamic damage Oxytocin Pituitary disease
description	Increasing evidence supports the presence of oxytocin deficiency (OXT-D) in patients with hypopituitarism and hypothalamic damage (HHD), that might be associated with neuropsychological deficits and sexual dysfunction, leading to worse quality of life (QoL). Therefore, identifying a provocative test to diagnose an OXT-D will be important. Corticotropin-releasing hormone (CRH) is a candidate for such a test as it increases oxytocin secretion in animal models. This study aimed to examine the effects of CRH on oxytocin release in HHD compared to healthy controls (HC) and to describe the psychopathology, sexual function and QoL and their associations with oxytocin. This is a single-blind, randomized, placebo-controlled, proof-of-concept study (NCT 04902235) with crossover assignment (CRH vs. placebo). Nineteen HHD patients (10 females) and 20 HC (11 females) completed two visits, receiving CRH or placebo in random order and completed validated questionnaires to assess psychopathology, sexual function and QoL. Samples were collected over 120 min to assess oxytocin. Linear mixed-effects regression model evaluated the change in oxytocin after CRH/placebo in HHD vs. HC. CRH administration did not impact oxytocin concentrations across groups over time (p = 0.97). HHD had greater psychopathology (most ps < 0.05), sexual dysfunction (p < 0.03) and worse QoL (p < 0.001) compared to HC, nevertheless, baseline oxytocin concentrations and area under the curve of oxytocin were not significantly associated with psychopathology, sexual function or QoL, neither in HHD or HC. In conclusion, CRH administration does not appear to be a suitable provocative test for diagnosing OXT-D in HHD. Identifying a reliable diagnostic test for OXT-D remains crucial. Alternative provocative tests or biomarkers should be explored.
publishDate	2025
dc.date.none.fl_str_mv	2 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/320380 https://dx.doi.org/urn:doi:10.1038/s41598-025-86566-y
url	https://ddd.uab.cat/record/320380 https://dx.doi.org/urn:doi:10.1038/s41598-025-86566-y
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01165
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
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dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
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Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage

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