Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography

Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in a...

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Autores: Roman, M, Louro, J, Posso, M, Vidal, C, Bargallo, X, Vazquez, I, Quintana, MJ, Alcantara, R, Saladie, F, del Riego, J, Penalva, L, Sala, M, Castells, X
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p9962
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9962
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125039019&doi=10.3390%2fijerph19052625&partnerID=40&md5=c6522595bc14e10290a79a29c8b7cedd
Access Level:acceso abierto
Palavra-chave:breast neoplasms
mass screening
longitudinal studies
benign breast disease
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spelling Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening MammographyRoman, MLouro, JPosso, MVidal, CBargallo, XVazquez, IQuintana, MJAlcantara, RSaladie, Fdel Riego, JPenalva, LSala, MCastells, Xbreast neoplasmsmass screeninglongitudinal studiesbenign breast diseaseAssessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9962https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125039019&doi=10.3390%2fijerph19052625&partnerID=40&md5=c6522595bc14e10290a79a29c8b7ceddInternational Journal of Environmental Research and Public HealthISSN: 16617827ISSNe: 16604601reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p99622026-06-14T12:41:47Z
dc.title.none.fl_str_mv Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
title Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
spellingShingle Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
Roman, M
breast neoplasms
mass screening
longitudinal studies
benign breast disease
title_short Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
title_full Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
title_fullStr Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
title_full_unstemmed Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
title_sort Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
dc.creator.none.fl_str_mv Roman, M
Louro, J
Posso, M
Vidal, C
Bargallo, X
Vazquez, I
Quintana, MJ
Alcantara, R
Saladie, F
del Riego, J
Penalva, L
Sala, M
Castells, X
author Roman, M
author_facet Roman, M
Louro, J
Posso, M
Vidal, C
Bargallo, X
Vazquez, I
Quintana, MJ
Alcantara, R
Saladie, F
del Riego, J
Penalva, L
Sala, M
Castells, X
author_role author
author2 Louro, J
Posso, M
Vidal, C
Bargallo, X
Vazquez, I
Quintana, MJ
Alcantara, R
Saladie, F
del Riego, J
Penalva, L
Sala, M
Castells, X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv breast neoplasms
mass screening
longitudinal studies
benign breast disease
topic breast neoplasms
mass screening
longitudinal studies
benign breast disease
description Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9962
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125039019&doi=10.3390%2fijerph19052625&partnerID=40&md5=c6522595bc14e10290a79a29c8b7cedd
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9962
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125039019&doi=10.3390%2fijerph19052625&partnerID=40&md5=c6522595bc14e10290a79a29c8b7cedd
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv International Journal of Environmental Research and Public Health
ISSN: 16617827
ISSNe: 16604601
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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