Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019

Epidemiology; HIV/HCV coinfection; Spain

Detalles Bibliográficos
Autores: Fanciulli, Chiara, Berenguer, Juan, Busca, Carmen, Vivancos, María J., Téllez, María J., Domínguez-Domínguez, Lourdes, Navarro Mercadé, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/8205
Acceso en línea:https://hdl.handle.net/11351/8205
http://hdl.handle.net/11351/8205
Access Level:acceso abierto
Palabra clave:Hepatitis C - Epidemiologia
Infeccions per VIH - Epidemiologia
DISEASES::Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
ENFERMEDADES::virosis::coinfección
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
title Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
spellingShingle Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
Fanciulli, Chiara
Hepatitis C - Epidemiologia
Infeccions per VIH - Epidemiologia
DISEASES::Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
ENFERMEDADES::virosis::coinfección
title_short Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
title_full Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
title_fullStr Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
title_full_unstemmed Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
title_sort Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
dc.creator.none.fl_str_mv Fanciulli, Chiara
Berenguer, Juan
Busca, Carmen
Vivancos, María J.
Téllez, María J.
Domínguez-Domínguez, Lourdes
Navarro Mercadé, Jordi
author Fanciulli, Chiara
author_facet Fanciulli, Chiara
Berenguer, Juan
Busca, Carmen
Vivancos, María J.
Téllez, María J.
Domínguez-Domínguez, Lourdes
Navarro Mercadé, Jordi
author_role author
author2 Berenguer, Juan
Busca, Carmen
Vivancos, María J.
Téllez, María J.
Domínguez-Domínguez, Lourdes
Navarro Mercadé, Jordi
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Fanciulli C, Berenguer J] Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain. Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. [Busca C] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario La Paz (IdiPAZ), Madrid, Spain. [Vivancos MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Ramón y Cajal (Irycis), Madrid, Spain. [Téllez MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Clínico San Carlos, Madrid, Spain. [Domínguez L] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain. [Navarro J] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hepatitis C - Epidemiologia
Infeccions per VIH - Epidemiologia
DISEASES::Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
ENFERMEDADES::virosis::coinfección
topic Hepatitis C - Epidemiologia
Infeccions per VIH - Epidemiologia
DISEASES::Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
ENFERMEDADES::virosis::coinfección
description Epidemiology; HIV/HCV coinfection; Spain
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8205
http://hdl.handle.net/11351/8205
url https://hdl.handle.net/11351/8205
http://hdl.handle.net/11351/8205
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv HIV Medicine;23(7)
https://doi.org/10.1111/hiv.13229
dc.rights.none.fl_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019Fanciulli, ChiaraBerenguer, JuanBusca, CarmenVivancos, María J.Téllez, María J.Domínguez-Domínguez, LourdesNavarro Mercadé, JordiHepatitis C - EpidemiologiaInfeccions per VIH - EpidemiologiaDISEASES::Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV InfectionsDISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis CDISEASES::Virus Diseases::CoinfectionENFERMEDADES::virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIHENFERMEDADES::virosis::hepatitis viral humana::hepatitis CENFERMEDADES::virosis::coinfecciónEpidemiology; HIV/HCV coinfection; SpainEpidemiologia; Coinfecció pel VIH/VHC; EspanyaEpidemiologia; Coinfección por el VIH/VHC; EspañaObjectives We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015–2018. Methods The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population.This work was supported in part by the Spanish AIDS Research Network (RD16/0025/0017, RD16/0025/0018), which is included in the Spanish I+D+I Plan and is co-funded by the ISCIII-Subdirección General de Evaluación and European Funding for Regional Development (FEDER). The sponsors had no role in the study design, the collection, analysis and interpretation of data, the writing of the report, or the decision to submit the article for publication.WileyInstitut Català de la Salut[Fanciulli C, Berenguer J] Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain. Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. [Busca C] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario La Paz (IdiPAZ), Madrid, Spain. [Vivancos MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Ramón y Cajal (Irycis), Madrid, Spain. [Téllez MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Clínico San Carlos, Madrid, Spain. [Domínguez L] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain. [Navarro J] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8205http://hdl.handle.net/11351/8205Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésHIV Medicine;23(7)https://doi.org/10.1111/hiv.13229Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/82052026-05-29T05:05:01Z
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