Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts

The Rel/NF-κB transcription factor family has myriad roles in immunity, development, and differentiation in animals, and was considered a key innovation for animal multicellularity. Rel homology domain-containing proteins were previously hypothesized to have originated in a last common ancestor of a...

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Detalles Bibliográficos
Autores: Leger, Michelle M., Ros I Rocher, Nuria Montserrat, Najle, Sebastián R., Ruiz-Trillo, Iñaki
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/272058
Acceso en línea:http://hdl.handle.net/10261/272058
Access Level:acceso abierto
Palabra clave:NF-κB
Rel homology domain
Transcription factors
Opisthokonts
NF-kappa B
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spelling Rel/NF-κB Transcription Factors Emerged at the Onset of OpisthokontsLeger, Michelle M.Ros I Rocher, Nuria MontserratNajle, Sebastián R.Ruiz-Trillo, IñakiNF-κBRel homology domainTranscription factorsOpisthokontsNF-kappa BThe Rel/NF-κB transcription factor family has myriad roles in immunity, development, and differentiation in animals, and was considered a key innovation for animal multicellularity. Rel homology domain-containing proteins were previously hypothesized to have originated in a last common ancestor of animals and some of their closest unicellular relatives. However, key taxa were missing from previous analyses, necessitating a systematic investigation into the distribution and evolution of these proteins. Here, we address this knowledge gap by surveying taxonomically broad data from eukaryotes, with a special emphasis on lineages closely related to animals. We report an earlier origin for Rel/NF-κB proteins than previously described, in the last common ancestor of animals and fungi, and show that even in the sister group to fungi, these proteins contain elements that in animals are necessary for the subcellular regulation of Rel/NF-κB.This work was supported by a European Research Council Consolidator Grant (ERC-2012-CO-616960) grant and a grant (BFU2017-90114-P) from Ministerio de Economía y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) to I.R.-T. M.M.L. was supported by a Marie Skłodowska-Curie Individual Fellowship under the EU Framework Programme for Research and Innovation Horizon 2020 (Project ID 747789) and an Ayuda Juan de la Cierva-Incorporación postdoctoral fellowship (IJC2018-036657-I) from the Spanish Ministry of Sciece and Innovation. N.R.-R. was supported by a “Formación del Profesorado Universitario (FPU13/01840)” PhD scholarship from the Spanish Ministerio de Educación, Cultura y Deporte (MECD).Peer reviewedOxford University PressEuropean Research CouncilMinisterio de Economía y Competitividad (España)Agencia Estatal de Investigación (España)European CommissionMinisterio de Ciencia e Innovación (España)Ministerio de Educación, Cultura y Deporte (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/272058reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/616960info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-90114-Pinfo:eu-repo/grantAgreement/EC/H2020/747789info:eu-repo/grantAgreement/MICINN//IJC2018-036657-Iinfo:eu-repo/grantAgreement/MECD//FPU13%2F01840The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1093/gbe/evab289https://doi.org/10.1093/gbe/evab289Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2720582026-05-22T06:33:51Z
dc.title.none.fl_str_mv Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
title Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
spellingShingle Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
Leger, Michelle M.
NF-κB
Rel homology domain
Transcription factors
Opisthokonts
NF-kappa B
title_short Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
title_full Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
title_fullStr Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
title_full_unstemmed Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
title_sort Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
dc.creator.none.fl_str_mv Leger, Michelle M.
Ros I Rocher, Nuria Montserrat
Najle, Sebastián R.
Ruiz-Trillo, Iñaki
author Leger, Michelle M.
author_facet Leger, Michelle M.
Ros I Rocher, Nuria Montserrat
Najle, Sebastián R.
Ruiz-Trillo, Iñaki
author_role author
author2 Ros I Rocher, Nuria Montserrat
Najle, Sebastián R.
Ruiz-Trillo, Iñaki
author2_role author
author
author
dc.contributor.none.fl_str_mv European Research Council
Ministerio de Economía y Competitividad (España)
Agencia Estatal de Investigación (España)
European Commission
Ministerio de Ciencia e Innovación (España)
Ministerio de Educación, Cultura y Deporte (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv NF-κB
Rel homology domain
Transcription factors
Opisthokonts
NF-kappa B
topic NF-κB
Rel homology domain
Transcription factors
Opisthokonts
NF-kappa B
description The Rel/NF-κB transcription factor family has myriad roles in immunity, development, and differentiation in animals, and was considered a key innovation for animal multicellularity. Rel homology domain-containing proteins were previously hypothesized to have originated in a last common ancestor of animals and some of their closest unicellular relatives. However, key taxa were missing from previous analyses, necessitating a systematic investigation into the distribution and evolution of these proteins. Here, we address this knowledge gap by surveying taxonomically broad data from eukaryotes, with a special emphasis on lineages closely related to animals. We report an earlier origin for Rel/NF-κB proteins than previously described, in the last common ancestor of animals and fungi, and show that even in the sister group to fungi, these proteins contain elements that in animals are necessary for the subcellular regulation of Rel/NF-κB.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/272058
url http://hdl.handle.net/10261/272058
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/616960
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-90114-P
info:eu-repo/grantAgreement/EC/H2020/747789
info:eu-repo/grantAgreement/MICINN//IJC2018-036657-I
info:eu-repo/grantAgreement/MECD//FPU13%2F01840
The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1093/gbe/evab289
https://doi.org/10.1093/gbe/evab289
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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