Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease
The cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes and associat...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:255451 |
| Acceso en línea: | https://ddd.uab.cat/record/255451 https://dx.doi.org/urn:doi:10.1186/s12883-021-02179-8 |
| Access Level: | acceso abierto |
| Palabra clave: | Cerebrovascular disease Mean arterial pressure Cerebral blood flow Cerebral autoregulation Diffuse correlation spectroscopy Diffuse optics |
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oai:ddd.uab.cat:255451 |
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España |
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| dc.title.none.fl_str_mv |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| spellingShingle |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease Gregori-Pla, Clara|||0000-0002-6623-0031 Cerebrovascular disease Mean arterial pressure Cerebral blood flow Cerebral autoregulation Diffuse correlation spectroscopy Diffuse optics |
| title_short |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_full |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_fullStr |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_full_unstemmed |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_sort |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| dc.creator.none.fl_str_mv |
Gregori-Pla, Clara|||0000-0002-6623-0031 Mesquita, Rickson C. Favilla, Christopher G. Busch, David R. Blanco, Igor|||0000-0001-7636-1177 Zirak, Peyman|||0000-0002-0331-6292 Frisk, Lisa Kobayashi Avtzi, Stella|||0000-0002-8893-3969 Maruccia, Federica|||0000-0002-3774-7875 Giacalone, Giacomo Cotta, Gianluca Camps-Renom, Pol|||0000-0001-6587-6271 Mullen, Michael T. Martí-Fàbregas, Joan|||0000-0001-9229-8649 Prats Sánchez, Luis Antonio|||0000-0002-3192-4631 Martínez-Domeño, Alejandro|||0000-0002-9933-3192 Kasner, Scott E. Greenberg, Joel H. Zhou, Chao Edlow, Brian L. Putt, Mary E. Detre, John A. Yodh, Arjun G. Durduran, Turgut|||0000-0001-5838-1027 Delgado Mederos, Raquel|||0000-0003-3737-7226 |
| author |
Gregori-Pla, Clara|||0000-0002-6623-0031 |
| author_facet |
Gregori-Pla, Clara|||0000-0002-6623-0031 Mesquita, Rickson C. Favilla, Christopher G. Busch, David R. Blanco, Igor|||0000-0001-7636-1177 Zirak, Peyman|||0000-0002-0331-6292 Frisk, Lisa Kobayashi Avtzi, Stella|||0000-0002-8893-3969 Maruccia, Federica|||0000-0002-3774-7875 Giacalone, Giacomo Cotta, Gianluca Camps-Renom, Pol|||0000-0001-6587-6271 Mullen, Michael T. Martí-Fàbregas, Joan|||0000-0001-9229-8649 Prats Sánchez, Luis Antonio|||0000-0002-3192-4631 Martínez-Domeño, Alejandro|||0000-0002-9933-3192 Kasner, Scott E. Greenberg, Joel H. Zhou, Chao Edlow, Brian L. Putt, Mary E. Detre, John A. Yodh, Arjun G. Durduran, Turgut|||0000-0001-5838-1027 Delgado Mederos, Raquel|||0000-0003-3737-7226 |
| author_role |
author |
| author2 |
Mesquita, Rickson C. Favilla, Christopher G. Busch, David R. Blanco, Igor|||0000-0001-7636-1177 Zirak, Peyman|||0000-0002-0331-6292 Frisk, Lisa Kobayashi Avtzi, Stella|||0000-0002-8893-3969 Maruccia, Federica|||0000-0002-3774-7875 Giacalone, Giacomo Cotta, Gianluca Camps-Renom, Pol|||0000-0001-6587-6271 Mullen, Michael T. Martí-Fàbregas, Joan|||0000-0001-9229-8649 Prats Sánchez, Luis Antonio|||0000-0002-3192-4631 Martínez-Domeño, Alejandro|||0000-0002-9933-3192 Kasner, Scott E. Greenberg, Joel H. Zhou, Chao Edlow, Brian L. Putt, Mary E. Detre, John A. Yodh, Arjun G. Durduran, Turgut|||0000-0001-5838-1027 Delgado Mederos, Raquel|||0000-0003-3737-7226 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Cerebrovascular disease Mean arterial pressure Cerebral blood flow Cerebral autoregulation Diffuse correlation spectroscopy Diffuse optics |
| topic |
Cerebrovascular disease Mean arterial pressure Cerebral blood flow Cerebral autoregulation Diffuse correlation spectroscopy Diffuse optics |
| description |
The cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes and associated systemic blood pressure changes has not been studied, even though blood pressure is a major driver of cerebral blood flow. Transcranial DCS data from four studies measuring bilateral frontal microvascular cerebral blood flow in healthy controls (n = 15), patients with asymptomatic severe internal carotid artery stenosis (ICA, n = 27), and patients with acute ischemic stroke (AIS, n = 72) were aggregated. DCS-measured CBF was measured in response to a short head-of-bed (HOB) position manipulation protocol (supine/elevated/supine, 5 min at each position). In a sub-group (AIS, n = 26; ICA, n = 14; control, n = 15), mean arterial pressure (MAP) was measured dynamically during the protocol. After elevated positioning, DCS CBF returned to baseline supine values in controls (p = 0.890) but not in patients with AIS (9.6% [6.0,13.3], mean 95% CI, p < 0.001) or ICA stenosis (8.6% [3.1,14.0], p = 0.003)). MAP in AIS patients did not return to baseline values (2.6 mmHg [0.5, 4.7], p = 0.018), but in ICA stenosis patients and controls did. Instead ipsilesional but not contralesional CBF was correlated with MAP (AIS 6.0%/mmHg [- 2.4,14.3], p = 0.038; ICA stenosis 11.0%/mmHg [2.4,19.5], p < 0.001). The observed associations between ipsilateral CBF and MAP suggest that short HOB position changes may elicit deficits in cerebral autoregulation in cerebrovascular disorders. Additional research is required to further characterize this phenomenon. The online version contains supplementary material available at 10.1186/s12883-021-02179-8. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/255451 https://dx.doi.org/urn:doi:10.1186/s12883-021-02179-8 |
| url |
https://ddd.uab.cat/record/255451 https://dx.doi.org/urn:doi:10.1186/s12883-021-02179-8 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PHOTODEMENTIA Ministerio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PHOTOMETABO Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 DPI2015-64358-C2-1-R Ministerio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PRE2018-085082 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/0557 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 MEDPHOTAGE Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 DTS16/00087 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1380 European Commission https://doi.org/10.13039/501100000780 654148 European Commission https://doi.org/10.13039/501100000780 713729 European Commission https://doi.org/10.13039/501100000780 317526 Fundació la Marató de TV3 https://doi.org/10.13039/100008666 201709.30 Fundació la Marató de TV3 https://doi.org/10.13039/100008666 201709.31 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular diseaseGregori-Pla, Clara|||0000-0002-6623-0031Mesquita, Rickson C.Favilla, Christopher G.Busch, David R.Blanco, Igor|||0000-0001-7636-1177Zirak, Peyman|||0000-0002-0331-6292Frisk, Lisa KobayashiAvtzi, Stella|||0000-0002-8893-3969Maruccia, Federica|||0000-0002-3774-7875Giacalone, GiacomoCotta, GianlucaCamps-Renom, Pol|||0000-0001-6587-6271Mullen, Michael T.Martí-Fàbregas, Joan|||0000-0001-9229-8649Prats Sánchez, Luis Antonio|||0000-0002-3192-4631Martínez-Domeño, Alejandro|||0000-0002-9933-3192Kasner, Scott E.Greenberg, Joel H.Zhou, ChaoEdlow, Brian L.Putt, Mary E.Detre, John A.Yodh, Arjun G.Durduran, Turgut|||0000-0001-5838-1027Delgado Mederos, Raquel|||0000-0003-3737-7226Cerebrovascular diseaseMean arterial pressureCerebral blood flowCerebral autoregulationDiffuse correlation spectroscopyDiffuse opticsThe cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes and associated systemic blood pressure changes has not been studied, even though blood pressure is a major driver of cerebral blood flow. Transcranial DCS data from four studies measuring bilateral frontal microvascular cerebral blood flow in healthy controls (n = 15), patients with asymptomatic severe internal carotid artery stenosis (ICA, n = 27), and patients with acute ischemic stroke (AIS, n = 72) were aggregated. DCS-measured CBF was measured in response to a short head-of-bed (HOB) position manipulation protocol (supine/elevated/supine, 5 min at each position). In a sub-group (AIS, n = 26; ICA, n = 14; control, n = 15), mean arterial pressure (MAP) was measured dynamically during the protocol. After elevated positioning, DCS CBF returned to baseline supine values in controls (p = 0.890) but not in patients with AIS (9.6% [6.0,13.3], mean 95% CI, p < 0.001) or ICA stenosis (8.6% [3.1,14.0], p = 0.003)). MAP in AIS patients did not return to baseline values (2.6 mmHg [0.5, 4.7], p = 0.018), but in ICA stenosis patients and controls did. Instead ipsilesional but not contralesional CBF was correlated with MAP (AIS 6.0%/mmHg [- 2.4,14.3], p = 0.038; ICA stenosis 11.0%/mmHg [2.4,19.5], p < 0.001). The observed associations between ipsilateral CBF and MAP suggest that short HOB position changes may elicit deficits in cerebral autoregulation in cerebrovascular disorders. Additional research is required to further characterize this phenomenon. The online version contains supplementary material available at 10.1186/s12883-021-02179-8.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255451https://dx.doi.org/urn:doi:10.1186/s12883-021-02179-8reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PHOTODEMENTIAMinisterio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PHOTOMETABOMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 DPI2015-64358-C2-1-RMinisterio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PRE2018-085082Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/0557Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 MEDPHOTAGEMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 DTS16/00087Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1380European Commission https://doi.org/10.13039/501100000780 654148European Commission https://doi.org/10.13039/501100000780 713729European Commission https://doi.org/10.13039/501100000780 317526Fundació la Marató de TV3 https://doi.org/10.13039/100008666 201709.30Fundació la Marató de TV3 https://doi.org/10.13039/100008666 201709.31open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2554512026-06-06T12:50:31Z |
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