Rethinking organoid technology through bioengineering

In recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step in this direction has also been the derivation of organoids. This technology generally relies on traditional three-dimensio...

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Authors: Garreta, Elena, Kamm, Roger D., Chuva de Sousa Lopes, Susana M., Lancaster, Madeline A., Weiss, Ron, Trepat Guixer, Xavier, Hyun, Insoo, Montserrat, Núria
Format: article
Status:Versión aceptada para publicación
Publication Date:2020
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173024
Online Access:https://hdl.handle.net/2445/173024
Access Level:Open access
Keyword:Cèl·lules mare
Bioenginyeria
Stem cells
Bioengineering
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spelling Rethinking organoid technology through bioengineeringGarreta, ElenaKamm, Roger D.Chuva de Sousa Lopes, Susana M.Lancaster, Madeline A.Weiss, RonTrepat Guixer, XavierHyun, InsooMontserrat, NúriaCèl·lules mareBioenginyeriaStem cellsBioengineeringIn recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step in this direction has also been the derivation of organoids. This technology generally relies on traditional three-dimensional culture techniques that exploit cell-autonomous self-organization responses of hPSCs with minimal control over the external inputs supplied to the system. The convergence of stem cell biology and bioengineering offers the possibility to provide these stimuli in a controlled fashion, resulting in the development of naturally inspired approaches to overcome major limitations of this nascent technology. Based on the current developments, we emphasize the achievements and ongoing challenges of bringing together hPSC organoid differentiation, bioengineering and ethics. This Review underlines the need for providing engineering solutions to gain control of self-organization and functionality of hPSC-derived organoids. We expect that this knowledge will guide the community to generate higher-grade hPSC-derived organoids for further applications in developmental biology, drug screening, disease modelling and personalized medicine.202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion11 p.application/pdfhttps://hdl.handle.net/2445/173024Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1038/s41563-020-00804-4Nature Materials, 2020, p. 145-155https://doi.org/10.1038/s41563-020-00804-4info:eu-repo/grantAgreement/EC/H2020/640525info:eu-repo/grantAgreement/EC/FP7/616480 info:eu-repo/grantAgreement/EC/H2020/725722info:eu-repo/grantAgreement/EC/H2020/757710(c) Springer Nature Limited, 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1730242026-05-29T05:05:01Z
dc.title.none.fl_str_mv Rethinking organoid technology through bioengineering
title Rethinking organoid technology through bioengineering
spellingShingle Rethinking organoid technology through bioengineering
Garreta, Elena
Cèl·lules mare
Bioenginyeria
Stem cells
Bioengineering
title_short Rethinking organoid technology through bioengineering
title_full Rethinking organoid technology through bioengineering
title_fullStr Rethinking organoid technology through bioengineering
title_full_unstemmed Rethinking organoid technology through bioengineering
title_sort Rethinking organoid technology through bioengineering
dc.creator.none.fl_str_mv Garreta, Elena
Kamm, Roger D.
Chuva de Sousa Lopes, Susana M.
Lancaster, Madeline A.
Weiss, Ron
Trepat Guixer, Xavier
Hyun, Insoo
Montserrat, Núria
author Garreta, Elena
author_facet Garreta, Elena
Kamm, Roger D.
Chuva de Sousa Lopes, Susana M.
Lancaster, Madeline A.
Weiss, Ron
Trepat Guixer, Xavier
Hyun, Insoo
Montserrat, Núria
author_role author
author2 Kamm, Roger D.
Chuva de Sousa Lopes, Susana M.
Lancaster, Madeline A.
Weiss, Ron
Trepat Guixer, Xavier
Hyun, Insoo
Montserrat, Núria
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules mare
Bioenginyeria
Stem cells
Bioengineering
topic Cèl·lules mare
Bioenginyeria
Stem cells
Bioengineering
description In recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step in this direction has also been the derivation of organoids. This technology generally relies on traditional three-dimensional culture techniques that exploit cell-autonomous self-organization responses of hPSCs with minimal control over the external inputs supplied to the system. The convergence of stem cell biology and bioengineering offers the possibility to provide these stimuli in a controlled fashion, resulting in the development of naturally inspired approaches to overcome major limitations of this nascent technology. Based on the current developments, we emphasize the achievements and ongoing challenges of bringing together hPSC organoid differentiation, bioengineering and ethics. This Review underlines the need for providing engineering solutions to gain control of self-organization and functionality of hPSC-derived organoids. We expect that this knowledge will guide the community to generate higher-grade hPSC-derived organoids for further applications in developmental biology, drug screening, disease modelling and personalized medicine.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173024
url https://hdl.handle.net/2445/173024
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1038/s41563-020-00804-4
Nature Materials, 2020, p. 145-155
https://doi.org/10.1038/s41563-020-00804-4
info:eu-repo/grantAgreement/EC/H2020/640525
info:eu-repo/grantAgreement/EC/FP7/616480
info:eu-repo/grantAgreement/EC/H2020/725722
info:eu-repo/grantAgreement/EC/H2020/757710
dc.rights.none.fl_str_mv (c) Springer Nature Limited, 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Nature Limited, 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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