Shared heritability and functional enrichment across six solid cancers

Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan P; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; Conti, David V; Casey, Graham; Gaudet, Mia M; Huyghe, Jeroen R; Albanes, Demetrius; Aldrich, Melinda C; Andrew, Angeline S; Andrulis, Irene L; Anton-Culver, Hoda; Antoniou, Antonis C; Antonenkova, Natalia N; Arnold, Susanne M; Aronson, Kristan J; Arun, Banu K; Bandera, Elisa V; Barkardottir, Rosa B; Barnes, Daniel R; Batra, Jyotsna; Beckmann, Matthias W; Benitez, Javier; Benlloch, Sara; Berchuck, Andrew; Berndt, Sonja I; Bickeböller, Heike; Bien, Stephanie A; Blomqvist, Carl; Boccia, Stefania; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Brauch, Hiltrud; Brenner, Hermann; Brenton, James D; Brook, Mark N; Brunet, Joan; Brunnström, Hans; Buchanan, Daniel D; Burwinkel, Barbara; Butzow, Ralf; Cadoni, Gabriella; Caldés, Trinidad; Caligo, Maria A; Campbell, Ian; Campbell, Peter T; Cancel-Tassin, Géraldine; Cannon-Albright, Lisa; Campa, Daniele; Caporaso, Neil; Carvalho, André L; Chan, Andrew T; Chang-Claude, Jenny; Chanock, Stephen J; Chen, Chu; Christiani, David C; Claes, Kathleen B M; Claessens, Frank; Clements, Judith; Collée, J Margriet; Correa, Marcia Cruz; Couch, Fergus J; Cox, Angela; Cunningham, Julie M; Cybulski, Cezary; Czene, Kamila; Daly, Mary B; deFazio, Anna; Devilee, Peter; Diez, Orland; Gago-Dominguez, Manuela; Donovan, Jenny L; Dörk, Thilo; Duell, Eric J; Dunning, Alison M; Dwek, Miriam; Eccles, Diana M; Edlund, Christopher K; Edwards, Digna R Velez; Ellberg, Carolina; Evans, D Gareth; Fasching, Peter A; Ferris, Robert L; Liloglou, Triantafillos; Figueiredo, Jane C; Fletcher, Olivia; Fortner, Renée T; Fostira, Florentia; Franceschi, Silvia; Friedman, Eitan; Gallinger, Steven J; Ganz, Patricia A; Garber, Judy; García-Sáenz, José A; Gayther, Simon A; Giles, Graham G; Godwin, Andrew K; Goldberg, Mark S; Goldgar, David E; Goode, Ellen L; Goodman, Marc T; Goodman, Gary; Grankvist, Kjell; Greene, Mark H; Gronberg, Henrik; Gronwald, Jacek; Guénel, Pascal; Håkansson, Niclas; Hall, Per; Hamann, Ute; Hamdy, Freddie C; Hamilton, Robert J; Hampe, Jochen; Haugen, Aage; Heitz, Florian; Herrero, Rolando; Hillemanns, Peter; Hoffmeister, Michael; Høgdall, Estrid; Hong, Yun-Chul; Hopper, John L; Houlston, Richard; Hulick, Peter J; Hunter, David J; Huntsman, David G; Idos, Gregory; Imyanitov, Evgeny N; Ingles, Sue Ann; Isaacs, Claudine; Jakubowska, Anna; James, Paul; Jenkins, Mark A; Johansson, Mattias; Johansson, Mikael; John, Esther M; Joshi, Amit D; Kaneva, Radka; Karlan, Beth Y; Kelemen, Linda E; Kühl, Tabea; Khaw, Kay-Tee; Khusnutdinova, Elza; Kibel, Adam S; Kiemeney, Lambertus A; Kim, Jeri; Kjaer, Susanne K; Knight, Julia A; Kogevinas, Manolis; Kote-Jarai, Zsofia; Koutros, Stella; Kristensen, Vessela N; Kupryjanczyk, Jolanta; Lacko, Martin; Lam, Stephan; Lambrechts, Diether; Landi, Maria Teresa; Lazarus, Philip; Le, Nhu D; Lee, Eunjung; Lejbkowicz, Flavio; Lenz, Heinz-Josef; Leslie, Goska; Lessel, Davor; Lester, Jenny; Levine, Douglas A; Li, Li; Li, Christopher I; Lindblom, Annika; Lindor, Noralane M; Liu, Geoffrey; Loupakis, Fotios; Lubiński, Jan; Maehle, Lovise; Maier, Christiane; Mannermaa, Arto; Marchand, Loic Le; Margolin, Sara; May, Taymaa; McGuffog, Lesley; Meindl, Alfons; Middha, Pooja; Miller, Austin; Milne, Roger L; MacInnis, Robert J; Modugno, Francesmary; Montagna, Marco; Moreno, Victor; Moysich, Kirsten B; Mucci, Lorelei; Muir, Kenneth; Mulligan, Anna Marie; Nathanson, Katherine L; Neal, David E; Ness, Andrew R; Neuhausen, Susan L; Nevanlinna, Heli; Newcomb, Polly A; Newcomb, Lisa F; Nielsen, Finn Cilius; Nikitina-Zake, Liene; Nordestgaard, Børge G; Nussbaum, Robert L; Offit, Kenneth; Olah, Edith; Olama, Ali Amin Al; Olopade, Olufunmilayo I; Olshan, Andrew F; Olsson, Håkan; Osorio, Ana; Pandha, Hardev; Park, Jong Y; Pashayan, Nora; Parsons, Michael T; Pejovic, Tanja; Penney, Kathryn L; Peters, Wilbert H M; Phelan, Catherine M; Phipps, Amanda I; Plaseska-Karanfilska, Dijana; Pring, Miranda; Prokofyeva, Darya; Radice, Paolo; Stefansson, Kari; Ramus, Susan J; Raskin, Leon; Rennert, Gad; Rennert, Hedy S; van Rensburg, Elizabeth J; Riggan, Marjorie J; Risch, Harvey A; Risch, Angela; Roobol, Monique J; Rosenstein, Barry S; Rossing, Mary Anne; De Ruyck, Kim; Saloustros, Emmanouil; Sandler, Dale P; Sawyer, Elinor J; Schabath, Matthew B; Schleutker, Johanna; Schmidt, Marjanka K; Setiawan, V Wendy; Shen, Hongbing; Siegel, Erin M; Sieh, Weiva; Singer, Christian F; Slattery, Martha L; Sorensen, Karina Dalsgaard; Southey, Melissa C; Spurdle, Amanda B; Stanford, Janet L; Stevens, Victoria L; Stintzing, Sebastian; Stone, Jennifer; Sundfeldt, Karin; Sutphen, Rebecca; Swerdlow, Anthony J; Tajara, Eloiza H; Tangen, Catherine M; Tardón, Adonina; Taylor, Jack A; Teare, M Dawn; Teixeira, Manuel R; Terry, Mary Beth; Terry, Kathryn L; Thibodeau, Stephen N; Thomassen, Mads; Bjørge, Line; Tischkowitz, Marc; Toland, Amanda E; Torres, Diana; Townsend, Paul A; Travis, Ruth C; Tung, Nadine; Tworoger, Shelley S; Ulrich, Cornelia M; Usmani, Nawaid; Vachon, Celine M; Van Nieuwenhuysen, Els; Vega, Ana; Aguado-Barrera, Miguel Elías; Wang, Qin; Webb, Penelope M; Weinberg, Clarice R; Weinstein, Stephanie; Weissler, Mark C; Weitzel, Jeffrey N; West, Catharine M L; White, Emily; Whittemore, Alice S; Wichmann, H-Erich; Wiklund, Fredrik; Winqvist, Robert; Wolk, Alicja; Woll, Penella; Woods, Michael; Wu, Anna H; Wu, Xifeng; Yannoukakos, Drakoulis; Zheng, Wei; Zienolddiny, Shanbeh; Ziogas, Argyrios; Zorn, Kristin K; Lane, Jacqueline M; Saxena, Richa; Thomas, Duncan; Hung, Rayjean J; Diergaarde, Brenda; McKay, James; Peters, Ulrike; Hsu, Li; García-Closas, Montserrat; Eeles, Rosalind A; Chenevix-Trench, Georgia; Brennan, Paul J; Haiman, Christopher A; Simard, Jacques; Easton, Douglas F; Gruber, Stephen B; Pharoah, Paul D P; Price, Alkes L; Pasaniuc, Bogdan; Amos, Christopher I; Kraft, Peter; Lindström, Sara

Shared heritability and functional enrichment across six solid cancers

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate...

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Detalles Bibliográficos
Autores:	Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen B M, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, deFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, Ganz, Patricia A, Garber, Judy, García-Sáenz, José A, Gayther, Simon A, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Goode, Ellen L, Goodman, Marc T, Goodman, Gary, Grankvist, Kjell, Greene, Mark H, Gronberg, Henrik, Gronwald, Jacek, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C, Hamilton, Robert J, Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Høgdall, Estrid, Hong, Yun-Chul, Hopper, John L, Houlston, Richard, Hulick, Peter J, Hunter, David J, Huntsman, David G, Idos, Gregory, Imyanitov, Evgeny N, Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A, Johansson, Mattias, Johansson, Mikael, John, Esther M, Joshi, Amit D, Kaneva, Radka, Karlan, Beth Y, Kelemen, Linda E, Kühl, Tabea, Khaw, Kay-Tee, Khusnutdinova, Elza, Kibel, Adam S, Kiemeney, Lambertus A, Kim, Jeri, Kjaer, Susanne K, Knight, Julia A, Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N, Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D, Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz-Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A, Li, Li, Li, Christopher I, Lindblom, Annika, Lindor, Noralane M, Liu, Geoffrey, Loupakis, Fotios, Lubiński, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Marchand, Loic Le, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L, MacInnis, Robert J, Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B, Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L, Neal, David E, Ness, Andrew R, Neuhausen, Susan L, Nevanlinna, Heli, Newcomb, Polly A, Newcomb, Lisa F, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Børge G, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olama, Ali Amin Al, Olopade, Olufunmilayo I, Olshan, Andrew F, Olsson, Håkan, Osorio, Ana, Pandha, Hardev, Park, Jong Y, Pashayan, Nora, Parsons, Michael T, Pejovic, Tanja, Penney, Kathryn L, Peters, Wilbert H M, Phelan, Catherine M, Phipps, Amanda I, Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, van Rensburg, Elizabeth J, Riggan, Marjorie J, Risch, Harvey A, Risch, Angela, Roobol, Monique J, Rosenstein, Barry S, Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schabath, Matthew B, Schleutker, Johanna, Schmidt, Marjanka K, Setiawan, V Wendy, Shen, Hongbing, Siegel, Erin M, Sieh, Weiva, Singer, Christian F, Slattery, Martha L, Sorensen, Karina Dalsgaard, Southey, Melissa C, Spurdle, Amanda B, Stanford, Janet L, Stevens, Victoria L, Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J, Tajara, Eloiza H, Tangen, Catherine M, Tardón, Adonina, Taylor, Jack A, Teare, M Dawn, Teixeira, Manuel R, Terry, Mary Beth, Terry, Kathryn L, Thibodeau, Stephen N, Thomassen, Mads, Bjørge, Line, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Townsend, Paul A, Travis, Ruth C, Tung, Nadine, Tworoger, Shelley S, Ulrich, Cornelia M, Usmani, Nawaid, Vachon, Celine M, Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elías, Wang, Qin, Webb, Penelope M, Weinberg, Clarice R, Weinstein, Stephanie, Weissler, Mark C, Weitzel, Jeffrey N, West, Catharine M L, White, Emily, Whittemore, Alice S, Wichmann, H-Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H, Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K, Lane, Jacqueline M, Saxena, Richa, Thomas, Duncan, Hung, Rayjean J, Diergaarde, Brenda, McKay, James, Peters, Ulrike, Hsu, Li, García-Closas, Montserrat, Eeles, Rosalind A, Chenevix-Trench, Georgia, Brennan, Paul J, Haiman, Christopher A, Simard, Jacques, Easton, Douglas F, Gruber, Stephen B, Pharoah, Paul D P, Price, Alkes L, Pasaniuc, Bogdan, Amos, Christopher I, Kraft, Peter, Lindström, Sara
Tipo de recurso:	artículo
Fecha de publicación:	2019
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/7477
Acceso en línea:	http://hdl.handle.net/20.500.12105/7477
Access Level:	acceso abierto
Palabra clave:	Breast Neoplasms Case-Control Studies Colorectal Neoplasms European Continental Ancestry Group Female Genetic Predisposition to Disease Genome-Wide Association Study

id	ES_8323ea9967ca8fc2adcbadfc809df4fb
oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/7477
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Shared heritability and functional enrichment across six solid cancers
title	Shared heritability and functional enrichment across six solid cancers
spellingShingle	Shared heritability and functional enrichment across six solid cancers Jiang, Xia Breast Neoplasms Case-Control Studies Colorectal Neoplasms European Continental Ancestry Group Female Genetic Predisposition to Disease Genome-Wide Association Study
title_short	Shared heritability and functional enrichment across six solid cancers
title_full	Shared heritability and functional enrichment across six solid cancers
title_fullStr	Shared heritability and functional enrichment across six solid cancers
title_full_unstemmed	Shared heritability and functional enrichment across six solid cancers
title_sort	Shared heritability and functional enrichment across six solid cancers
dc.creator.none.fl_str_mv	Jiang, Xia Finucane, Hilary K Schumacher, Fredrick R Schmit, Stephanie L Tyrer, Jonathan P Han, Younghun Michailidou, Kyriaki Lesseur, Corina Kuchenbaecker, Karoline B Dennis, Joe Conti, David V Casey, Graham Gaudet, Mia M Huyghe, Jeroen R Albanes, Demetrius Aldrich, Melinda C Andrew, Angeline S Andrulis, Irene L Anton-Culver, Hoda Antoniou, Antonis C Antonenkova, Natalia N Arnold, Susanne M Aronson, Kristan J Arun, Banu K Bandera, Elisa V Barkardottir, Rosa B Barnes, Daniel R Batra, Jyotsna Beckmann, Matthias W Benitez, Javier Benlloch, Sara Berchuck, Andrew Berndt, Sonja I Bickeböller, Heike Bien, Stephanie A Blomqvist, Carl Boccia, Stefania Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Brenton, James D Brook, Mark N Brunet, Joan Brunnström, Hans Buchanan, Daniel D Burwinkel, Barbara Butzow, Ralf Cadoni, Gabriella Caldés, Trinidad Caligo, Maria A Campbell, Ian Campbell, Peter T Cancel-Tassin, Géraldine Cannon-Albright, Lisa Campa, Daniele Caporaso, Neil Carvalho, André L Chan, Andrew T Chang-Claude, Jenny Chanock, Stephen J Chen, Chu Christiani, David C Claes, Kathleen B M Claessens, Frank Clements, Judith Collée, J Margriet Correa, Marcia Cruz Couch, Fergus J Cox, Angela Cunningham, Julie M Cybulski, Cezary Czene, Kamila Daly, Mary B deFazio, Anna Devilee, Peter Diez, Orland Gago-Dominguez, Manuela Donovan, Jenny L Dörk, Thilo Duell, Eric J Dunning, Alison M Dwek, Miriam Eccles, Diana M Edlund, Christopher K Edwards, Digna R Velez Ellberg, Carolina Evans, D Gareth Fasching, Peter A Ferris, Robert L Liloglou, Triantafillos Figueiredo, Jane C Fletcher, Olivia Fortner, Renée T Fostira, Florentia Franceschi, Silvia Friedman, Eitan Gallinger, Steven J Ganz, Patricia A Garber, Judy García-Sáenz, José A Gayther, Simon A Giles, Graham G Godwin, Andrew K Goldberg, Mark S Goldgar, David E Goode, Ellen L Goodman, Marc T Goodman, Gary Grankvist, Kjell Greene, Mark H Gronberg, Henrik Gronwald, Jacek Guénel, Pascal Håkansson, Niclas Hall, Per Hamann, Ute Hamdy, Freddie C Hamilton, Robert J Hampe, Jochen Haugen, Aage Heitz, Florian Herrero, Rolando Hillemanns, Peter Hoffmeister, Michael Høgdall, Estrid Hong, Yun-Chul Hopper, John L Houlston, Richard Hulick, Peter J Hunter, David J Huntsman, David G Idos, Gregory Imyanitov, Evgeny N Ingles, Sue Ann Isaacs, Claudine Jakubowska, Anna James, Paul Jenkins, Mark A Johansson, Mattias Johansson, Mikael John, Esther M Joshi, Amit D Kaneva, Radka Karlan, Beth Y Kelemen, Linda E Kühl, Tabea Khaw, Kay-Tee Khusnutdinova, Elza Kibel, Adam S Kiemeney, Lambertus A Kim, Jeri Kjaer, Susanne K Knight, Julia A Kogevinas, Manolis Kote-Jarai, Zsofia Koutros, Stella Kristensen, Vessela N Kupryjanczyk, Jolanta Lacko, Martin Lam, Stephan Lambrechts, Diether Landi, Maria Teresa Lazarus, Philip Le, Nhu D Lee, Eunjung Lejbkowicz, Flavio Lenz, Heinz-Josef Leslie, Goska Lessel, Davor Lester, Jenny Levine, Douglas A Li, Li Li, Christopher I Lindblom, Annika Lindor, Noralane M Liu, Geoffrey Loupakis, Fotios Lubiński, Jan Maehle, Lovise Maier, Christiane Mannermaa, Arto Marchand, Loic Le Margolin, Sara May, Taymaa McGuffog, Lesley Meindl, Alfons Middha, Pooja Miller, Austin Milne, Roger L MacInnis, Robert J Modugno, Francesmary Montagna, Marco Moreno, Victor Moysich, Kirsten B Mucci, Lorelei Muir, Kenneth Mulligan, Anna Marie Nathanson, Katherine L Neal, David E Ness, Andrew R Neuhausen, Susan L Nevanlinna, Heli Newcomb, Polly A Newcomb, Lisa F Nielsen, Finn Cilius Nikitina-Zake, Liene Nordestgaard, Børge G Nussbaum, Robert L Offit, Kenneth Olah, Edith Olama, Ali Amin Al Olopade, Olufunmilayo I Olshan, Andrew F Olsson, Håkan Osorio, Ana Pandha, Hardev Park, Jong Y Pashayan, Nora Parsons, Michael T Pejovic, Tanja Penney, Kathryn L Peters, Wilbert H M Phelan, Catherine M Phipps, Amanda I Plaseska-Karanfilska, Dijana Pring, Miranda Prokofyeva, Darya Radice, Paolo Stefansson, Kari Ramus, Susan J Raskin, Leon Rennert, Gad Rennert, Hedy S van Rensburg, Elizabeth J Riggan, Marjorie J Risch, Harvey A Risch, Angela Roobol, Monique J Rosenstein, Barry S Rossing, Mary Anne De Ruyck, Kim Saloustros, Emmanouil Sandler, Dale P Sawyer, Elinor J Schabath, Matthew B Schleutker, Johanna Schmidt, Marjanka K Setiawan, V Wendy Shen, Hongbing Siegel, Erin M Sieh, Weiva Singer, Christian F Slattery, Martha L Sorensen, Karina Dalsgaard Southey, Melissa C Spurdle, Amanda B Stanford, Janet L Stevens, Victoria L Stintzing, Sebastian Stone, Jennifer Sundfeldt, Karin Sutphen, Rebecca Swerdlow, Anthony J Tajara, Eloiza H Tangen, Catherine M Tardón, Adonina Taylor, Jack A Teare, M Dawn Teixeira, Manuel R Terry, Mary Beth Terry, Kathryn L Thibodeau, Stephen N Thomassen, Mads Bjørge, Line Tischkowitz, Marc Toland, Amanda E Torres, Diana Townsend, Paul A Travis, Ruth C Tung, Nadine Tworoger, Shelley S Ulrich, Cornelia M Usmani, Nawaid Vachon, Celine M Van Nieuwenhuysen, Els Vega, Ana Aguado-Barrera, Miguel Elías Wang, Qin Webb, Penelope M Weinberg, Clarice R Weinstein, Stephanie Weissler, Mark C Weitzel, Jeffrey N West, Catharine M L White, Emily Whittemore, Alice S Wichmann, H-Erich Wiklund, Fredrik Winqvist, Robert Wolk, Alicja Woll, Penella Woods, Michael Wu, Anna H Wu, Xifeng Yannoukakos, Drakoulis Zheng, Wei Zienolddiny, Shanbeh Ziogas, Argyrios Zorn, Kristin K Lane, Jacqueline M Saxena, Richa Thomas, Duncan Hung, Rayjean J Diergaarde, Brenda McKay, James Peters, Ulrike Hsu, Li García-Closas, Montserrat Eeles, Rosalind A Chenevix-Trench, Georgia Brennan, Paul J Haiman, Christopher A Simard, Jacques Easton, Douglas F Gruber, Stephen B Pharoah, Paul D P Price, Alkes L Pasaniuc, Bogdan Amos, Christopher I Kraft, Peter Lindström, Sara
author	Jiang, Xia
author_facet	Jiang, Xia Finucane, Hilary K Schumacher, Fredrick R Schmit, Stephanie L Tyrer, Jonathan P Han, Younghun Michailidou, Kyriaki Lesseur, Corina Kuchenbaecker, Karoline B Dennis, Joe Conti, David V Casey, Graham Gaudet, Mia M Huyghe, Jeroen R Albanes, Demetrius Aldrich, Melinda C Andrew, Angeline S Andrulis, Irene L Anton-Culver, Hoda Antoniou, Antonis C Antonenkova, Natalia N Arnold, Susanne M Aronson, Kristan J Arun, Banu K Bandera, Elisa V Barkardottir, Rosa B Barnes, Daniel R Batra, Jyotsna Beckmann, Matthias W Benitez, Javier Benlloch, Sara Berchuck, Andrew Berndt, Sonja I Bickeböller, Heike Bien, Stephanie A Blomqvist, Carl Boccia, Stefania Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Brenton, James D Brook, Mark N Brunet, Joan Brunnström, Hans Buchanan, Daniel D Burwinkel, Barbara Butzow, Ralf Cadoni, Gabriella Caldés, Trinidad Caligo, Maria A Campbell, Ian Campbell, Peter T Cancel-Tassin, Géraldine Cannon-Albright, Lisa Campa, Daniele Caporaso, Neil Carvalho, André L Chan, Andrew T Chang-Claude, Jenny Chanock, Stephen J Chen, Chu Christiani, David C Claes, Kathleen B M Claessens, Frank Clements, Judith Collée, J Margriet Correa, Marcia Cruz Couch, Fergus J Cox, Angela Cunningham, Julie M Cybulski, Cezary Czene, Kamila Daly, Mary B deFazio, Anna Devilee, Peter Diez, Orland Gago-Dominguez, Manuela Donovan, Jenny L Dörk, Thilo Duell, Eric J Dunning, Alison M Dwek, Miriam Eccles, Diana M Edlund, Christopher K Edwards, Digna R Velez Ellberg, Carolina Evans, D Gareth Fasching, Peter A Ferris, Robert L Liloglou, Triantafillos Figueiredo, Jane C Fletcher, Olivia Fortner, Renée T Fostira, Florentia Franceschi, Silvia Friedman, Eitan Gallinger, Steven J Ganz, Patricia A Garber, Judy García-Sáenz, José A Gayther, Simon A Giles, Graham G Godwin, Andrew K Goldberg, Mark S Goldgar, David E Goode, Ellen L Goodman, Marc T Goodman, Gary Grankvist, Kjell Greene, Mark H Gronberg, Henrik Gronwald, Jacek Guénel, Pascal Håkansson, Niclas Hall, Per Hamann, Ute Hamdy, Freddie C Hamilton, Robert J Hampe, Jochen Haugen, Aage Heitz, Florian Herrero, Rolando Hillemanns, Peter Hoffmeister, Michael Høgdall, Estrid Hong, Yun-Chul Hopper, John L Houlston, Richard Hulick, Peter J Hunter, David J Huntsman, David G Idos, Gregory Imyanitov, Evgeny N Ingles, Sue Ann Isaacs, Claudine Jakubowska, Anna James, Paul Jenkins, Mark A Johansson, Mattias Johansson, Mikael John, Esther M Joshi, Amit D Kaneva, Radka Karlan, Beth Y Kelemen, Linda E Kühl, Tabea Khaw, Kay-Tee Khusnutdinova, Elza Kibel, Adam S Kiemeney, Lambertus A Kim, Jeri Kjaer, Susanne K Knight, Julia A Kogevinas, Manolis Kote-Jarai, Zsofia Koutros, Stella Kristensen, Vessela N Kupryjanczyk, Jolanta Lacko, Martin Lam, Stephan Lambrechts, Diether Landi, Maria Teresa Lazarus, Philip Le, Nhu D Lee, Eunjung Lejbkowicz, Flavio Lenz, Heinz-Josef Leslie, Goska Lessel, Davor Lester, Jenny Levine, Douglas A Li, Li Li, Christopher I Lindblom, Annika Lindor, Noralane M Liu, Geoffrey Loupakis, Fotios Lubiński, Jan Maehle, Lovise Maier, Christiane Mannermaa, Arto Marchand, Loic Le Margolin, Sara May, Taymaa McGuffog, Lesley Meindl, Alfons Middha, Pooja Miller, Austin Milne, Roger L MacInnis, Robert J Modugno, Francesmary Montagna, Marco Moreno, Victor Moysich, Kirsten B Mucci, Lorelei Muir, Kenneth Mulligan, Anna Marie Nathanson, Katherine L Neal, David E Ness, Andrew R Neuhausen, Susan L Nevanlinna, Heli Newcomb, Polly A Newcomb, Lisa F Nielsen, Finn Cilius Nikitina-Zake, Liene Nordestgaard, Børge G Nussbaum, Robert L Offit, Kenneth Olah, Edith Olama, Ali Amin Al Olopade, Olufunmilayo I Olshan, Andrew F Olsson, Håkan Osorio, Ana Pandha, Hardev Park, Jong Y Pashayan, Nora Parsons, Michael T Pejovic, Tanja Penney, Kathryn L Peters, Wilbert H M Phelan, Catherine M Phipps, Amanda I Plaseska-Karanfilska, Dijana Pring, Miranda Prokofyeva, Darya Radice, Paolo Stefansson, Kari Ramus, Susan J Raskin, Leon Rennert, Gad Rennert, Hedy S van Rensburg, Elizabeth J Riggan, Marjorie J Risch, Harvey A Risch, Angela Roobol, Monique J Rosenstein, Barry S Rossing, Mary Anne De Ruyck, Kim Saloustros, Emmanouil Sandler, Dale P Sawyer, Elinor J Schabath, Matthew B Schleutker, Johanna Schmidt, Marjanka K Setiawan, V Wendy Shen, Hongbing Siegel, Erin M Sieh, Weiva Singer, Christian F Slattery, Martha L Sorensen, Karina Dalsgaard Southey, Melissa C Spurdle, Amanda B Stanford, Janet L Stevens, Victoria L Stintzing, Sebastian Stone, Jennifer Sundfeldt, Karin Sutphen, Rebecca Swerdlow, Anthony J Tajara, Eloiza H Tangen, Catherine M Tardón, Adonina Taylor, Jack A Teare, M Dawn Teixeira, Manuel R Terry, Mary Beth Terry, Kathryn L Thibodeau, Stephen N Thomassen, Mads Bjørge, Line Tischkowitz, Marc Toland, Amanda E Torres, Diana Townsend, Paul A Travis, Ruth C Tung, Nadine Tworoger, Shelley S Ulrich, Cornelia M Usmani, Nawaid Vachon, Celine M Van Nieuwenhuysen, Els Vega, Ana Aguado-Barrera, Miguel Elías Wang, Qin Webb, Penelope M Weinberg, Clarice R Weinstein, Stephanie Weissler, Mark C Weitzel, Jeffrey N West, Catharine M L White, Emily Whittemore, Alice S Wichmann, H-Erich Wiklund, Fredrik Winqvist, Robert Wolk, Alicja Woll, Penella Woods, Michael Wu, Anna H Wu, Xifeng Yannoukakos, Drakoulis Zheng, Wei Zienolddiny, Shanbeh Ziogas, Argyrios Zorn, Kristin K Lane, Jacqueline M Saxena, Richa Thomas, Duncan Hung, Rayjean J Diergaarde, Brenda McKay, James Peters, Ulrike Hsu, Li García-Closas, Montserrat Eeles, Rosalind A Chenevix-Trench, Georgia Brennan, Paul J Haiman, Christopher A Simard, Jacques Easton, Douglas F Gruber, Stephen B Pharoah, Paul D P Price, Alkes L Pasaniuc, Bogdan Amos, Christopher I Kraft, Peter Lindström, Sara
author_role	author
author2	Finucane, Hilary K Schumacher, Fredrick R Schmit, Stephanie L Tyrer, Jonathan P Han, Younghun Michailidou, Kyriaki Lesseur, Corina Kuchenbaecker, Karoline B Dennis, Joe Conti, David V Casey, Graham Gaudet, Mia M Huyghe, Jeroen R Albanes, Demetrius Aldrich, Melinda C Andrew, Angeline S Andrulis, Irene L Anton-Culver, Hoda Antoniou, Antonis C Antonenkova, Natalia N Arnold, Susanne M Aronson, Kristan J Arun, Banu K Bandera, Elisa V Barkardottir, Rosa B Barnes, Daniel R Batra, Jyotsna Beckmann, Matthias W Benitez, Javier Benlloch, Sara Berchuck, Andrew Berndt, Sonja I Bickeböller, Heike Bien, Stephanie A Blomqvist, Carl Boccia, Stefania Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Brenton, James D Brook, Mark N Brunet, Joan Brunnström, Hans Buchanan, Daniel D Burwinkel, Barbara Butzow, Ralf Cadoni, Gabriella Caldés, Trinidad Caligo, Maria A Campbell, Ian Campbell, Peter T Cancel-Tassin, Géraldine Cannon-Albright, Lisa Campa, Daniele Caporaso, Neil Carvalho, André L Chan, Andrew T Chang-Claude, Jenny Chanock, Stephen J Chen, Chu Christiani, David C Claes, Kathleen B M Claessens, Frank Clements, Judith Collée, J Margriet Correa, Marcia Cruz Couch, Fergus J Cox, Angela Cunningham, Julie M Cybulski, Cezary Czene, Kamila Daly, Mary B deFazio, Anna Devilee, Peter Diez, Orland Gago-Dominguez, Manuela Donovan, Jenny L Dörk, Thilo Duell, Eric J Dunning, Alison M Dwek, Miriam Eccles, Diana M Edlund, Christopher K Edwards, Digna R Velez Ellberg, Carolina Evans, D Gareth Fasching, Peter A Ferris, Robert L Liloglou, Triantafillos Figueiredo, Jane C Fletcher, Olivia Fortner, Renée T Fostira, Florentia Franceschi, Silvia Friedman, Eitan Gallinger, Steven J Ganz, Patricia A Garber, Judy García-Sáenz, José A Gayther, Simon A Giles, Graham G Godwin, Andrew K Goldberg, Mark S Goldgar, David E Goode, Ellen L Goodman, Marc T Goodman, Gary Grankvist, Kjell Greene, Mark H Gronberg, Henrik Gronwald, Jacek Guénel, Pascal Håkansson, Niclas Hall, Per Hamann, Ute Hamdy, Freddie C Hamilton, Robert J Hampe, Jochen Haugen, Aage Heitz, Florian Herrero, Rolando Hillemanns, Peter Hoffmeister, Michael Høgdall, Estrid Hong, Yun-Chul Hopper, John L Houlston, Richard Hulick, Peter J Hunter, David J Huntsman, David G Idos, Gregory Imyanitov, Evgeny N Ingles, Sue Ann Isaacs, Claudine Jakubowska, Anna James, Paul Jenkins, Mark A Johansson, Mattias Johansson, Mikael John, Esther M Joshi, Amit D Kaneva, Radka Karlan, Beth Y Kelemen, Linda E Kühl, Tabea Khaw, Kay-Tee Khusnutdinova, Elza Kibel, Adam S Kiemeney, Lambertus A Kim, Jeri Kjaer, Susanne K Knight, Julia A Kogevinas, Manolis Kote-Jarai, Zsofia Koutros, Stella Kristensen, Vessela N Kupryjanczyk, Jolanta Lacko, Martin Lam, Stephan Lambrechts, Diether Landi, Maria Teresa Lazarus, Philip Le, Nhu D Lee, Eunjung Lejbkowicz, Flavio Lenz, Heinz-Josef Leslie, Goska Lessel, Davor Lester, Jenny Levine, Douglas A Li, Li Li, Christopher I Lindblom, Annika Lindor, Noralane M Liu, Geoffrey Loupakis, Fotios Lubiński, Jan Maehle, Lovise Maier, Christiane Mannermaa, Arto Marchand, Loic Le Margolin, Sara May, Taymaa McGuffog, Lesley Meindl, Alfons Middha, Pooja Miller, Austin Milne, Roger L MacInnis, Robert J Modugno, Francesmary Montagna, Marco Moreno, Victor Moysich, Kirsten B Mucci, Lorelei Muir, Kenneth Mulligan, Anna Marie Nathanson, Katherine L Neal, David E Ness, Andrew R Neuhausen, Susan L Nevanlinna, Heli Newcomb, Polly A Newcomb, Lisa F Nielsen, Finn Cilius Nikitina-Zake, Liene Nordestgaard, Børge G Nussbaum, Robert L Offit, Kenneth Olah, Edith Olama, Ali Amin Al Olopade, Olufunmilayo I Olshan, Andrew F Olsson, Håkan Osorio, Ana Pandha, Hardev Park, Jong Y Pashayan, Nora Parsons, Michael T Pejovic, Tanja Penney, Kathryn L Peters, Wilbert H M Phelan, Catherine M Phipps, Amanda I Plaseska-Karanfilska, Dijana Pring, Miranda Prokofyeva, Darya Radice, Paolo Stefansson, Kari Ramus, Susan J Raskin, Leon Rennert, Gad Rennert, Hedy S van Rensburg, Elizabeth J Riggan, Marjorie J Risch, Harvey A Risch, Angela Roobol, Monique J Rosenstein, Barry S Rossing, Mary Anne De Ruyck, Kim Saloustros, Emmanouil Sandler, Dale P Sawyer, Elinor J Schabath, Matthew B Schleutker, Johanna Schmidt, Marjanka K Setiawan, V Wendy Shen, Hongbing Siegel, Erin M Sieh, Weiva Singer, Christian F Slattery, Martha L Sorensen, Karina Dalsgaard Southey, Melissa C Spurdle, Amanda B Stanford, Janet L Stevens, Victoria L Stintzing, Sebastian Stone, Jennifer Sundfeldt, Karin Sutphen, Rebecca Swerdlow, Anthony J Tajara, Eloiza H Tangen, Catherine M Tardón, Adonina Taylor, Jack A Teare, M Dawn Teixeira, Manuel R Terry, Mary Beth Terry, Kathryn L Thibodeau, Stephen N Thomassen, Mads Bjørge, Line Tischkowitz, Marc Toland, Amanda E Torres, Diana Townsend, Paul A Travis, Ruth C Tung, Nadine Tworoger, Shelley S Ulrich, Cornelia M Usmani, Nawaid Vachon, Celine M Van Nieuwenhuysen, Els Vega, Ana Aguado-Barrera, Miguel Elías Wang, Qin Webb, Penelope M Weinberg, Clarice R Weinstein, Stephanie Weissler, Mark C Weitzel, Jeffrey N West, Catharine M L White, Emily Whittemore, Alice S Wichmann, H-Erich Wiklund, Fredrik Winqvist, Robert Wolk, Alicja Woll, Penella Woods, Michael Wu, Anna H Wu, Xifeng Yannoukakos, Drakoulis Zheng, Wei Zienolddiny, Shanbeh Ziogas, Argyrios Zorn, Kristin K Lane, Jacqueline M Saxena, Richa Thomas, Duncan Hung, Rayjean J Diergaarde, Brenda McKay, James Peters, Ulrike Hsu, Li García-Closas, Montserrat Eeles, Rosalind A Chenevix-Trench, Georgia Brennan, Paul J Haiman, Christopher A Simard, Jacques Easton, Douglas F Gruber, Stephen B Pharoah, Paul D P Price, Alkes L Pasaniuc, Bogdan Amos, Christopher I Kraft, Peter Lindström, Sara
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Cancer Research UK (Reino Unido) NIHR - Comprehensive Biomedical Research Centre Guy ’ s & St. Thomas ’ NHS Foundation Trust NIHR - Oxford Biomedical Research Centre (Reino Unido) German Cancer Research Center Consejo Nacional de Ciencia y Tecnología (México) King College London National Health and Medical Research Council (Australia) Canadian Institutes of Health Research The BREast Oncology GAlician Network (BREOGAN Dietmar-Hopp Foundation Helmholtz Society and the German Cancer Research Center (DKFZ) Asociación Española Contra el Cáncer
dc.subject.none.fl_str_mv	Breast Neoplasms Case-Control Studies Colorectal Neoplasms European Continental Ancestry Group Female Genetic Predisposition to Disease Genome-Wide Association Study
topic	Breast Neoplasms Case-Control Studies Colorectal Neoplasms European Continental Ancestry Group Female Genetic Predisposition to Disease Genome-Wide Association Study
description	Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
publishDate	2019
dc.date.none.fl_str_mv	2019 2019-04-22 2019 2019-01-25 2019 2019-01-25
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/7477
url	http://hdl.handle.net/20.500.12105/7477
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	ES PI12 02125 ES PI13 01136
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Nature Publishing Group
publisher.none.fl_str_mv	Nature Publishing Group
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869412112310206464
spelling	Shared heritability and functional enrichment across six solid cancersJiang, XiaFinucane, Hilary KSchumacher, Fredrick RSchmit, Stephanie LTyrer, Jonathan PHan, YounghunMichailidou, KyriakiLesseur, CorinaKuchenbaecker, Karoline BDennis, JoeConti, David VCasey, GrahamGaudet, Mia MHuyghe, Jeroen RAlbanes, DemetriusAldrich, Melinda CAndrew, Angeline SAndrulis, Irene LAnton-Culver, HodaAntoniou, Antonis CAntonenkova, Natalia NArnold, Susanne MAronson, Kristan JArun, Banu KBandera, Elisa VBarkardottir, Rosa BBarnes, Daniel RBatra, JyotsnaBeckmann, Matthias WBenitez, JavierBenlloch, SaraBerchuck, AndrewBerndt, Sonja IBickeböller, HeikeBien, Stephanie ABlomqvist, CarlBoccia, StefaniaBogdanova, Natalia VBojesen, Stig EBolla, Manjeet KBrauch, HiltrudBrenner, HermannBrenton, James DBrook, Mark NBrunet, JoanBrunnström, HansBuchanan, Daniel DBurwinkel, BarbaraButzow, RalfCadoni, GabriellaCaldés, TrinidadCaligo, Maria ACampbell, IanCampbell, Peter TCancel-Tassin, GéraldineCannon-Albright, LisaCampa, DanieleCaporaso, NeilCarvalho, André LChan, Andrew TChang-Claude, JennyChanock, Stephen JChen, ChuChristiani, David CClaes, Kathleen B MClaessens, FrankClements, JudithCollée, J MargrietCorrea, Marcia CruzCouch, Fergus JCox, AngelaCunningham, Julie MCybulski, CezaryCzene, KamilaDaly, Mary BdeFazio, AnnaDevilee, PeterDiez, OrlandGago-Dominguez, ManuelaDonovan, Jenny LDörk, ThiloDuell, Eric JDunning, Alison MDwek, MiriamEccles, Diana MEdlund, Christopher KEdwards, Digna R VelezEllberg, CarolinaEvans, D GarethFasching, Peter AFerris, Robert LLiloglou, TriantafillosFigueiredo, Jane CFletcher, OliviaFortner, Renée TFostira, FlorentiaFranceschi, SilviaFriedman, EitanGallinger, Steven JGanz, Patricia AGarber, JudyGarcía-Sáenz, José AGayther, Simon AGiles, Graham GGodwin, Andrew KGoldberg, Mark SGoldgar, David EGoode, Ellen LGoodman, Marc TGoodman, GaryGrankvist, KjellGreene, Mark HGronberg, HenrikGronwald, JacekGuénel, PascalHåkansson, NiclasHall, PerHamann, UteHamdy, Freddie CHamilton, Robert JHampe, JochenHaugen, AageHeitz, FlorianHerrero, RolandoHillemanns, PeterHoffmeister, MichaelHøgdall, EstridHong, Yun-ChulHopper, John LHoulston, RichardHulick, Peter JHunter, David JHuntsman, David GIdos, GregoryImyanitov, Evgeny NIngles, Sue AnnIsaacs, ClaudineJakubowska, AnnaJames, PaulJenkins, Mark AJohansson, MattiasJohansson, MikaelJohn, Esther MJoshi, Amit DKaneva, RadkaKarlan, Beth YKelemen, Linda EKühl, TabeaKhaw, Kay-TeeKhusnutdinova, ElzaKibel, Adam SKiemeney, Lambertus AKim, JeriKjaer, Susanne KKnight, Julia AKogevinas, ManolisKote-Jarai, ZsofiaKoutros, StellaKristensen, Vessela NKupryjanczyk, JolantaLacko, MartinLam, StephanLambrechts, DietherLandi, Maria TeresaLazarus, PhilipLe, Nhu DLee, EunjungLejbkowicz, FlavioLenz, Heinz-JosefLeslie, GoskaLessel, DavorLester, JennyLevine, Douglas ALi, LiLi, Christopher ILindblom, AnnikaLindor, Noralane MLiu, GeoffreyLoupakis, FotiosLubiński, JanMaehle, LoviseMaier, ChristianeMannermaa, ArtoMarchand, Loic LeMargolin, SaraMay, TaymaaMcGuffog, LesleyMeindl, AlfonsMiddha, PoojaMiller, AustinMilne, Roger LMacInnis, Robert JModugno, FrancesmaryMontagna, MarcoMoreno, VictorMoysich, Kirsten BMucci, LoreleiMuir, KennethMulligan, Anna MarieNathanson, Katherine LNeal, David ENess, Andrew RNeuhausen, Susan LNevanlinna, HeliNewcomb, Polly ANewcomb, Lisa FNielsen, Finn CiliusNikitina-Zake, LieneNordestgaard, Børge GNussbaum, Robert LOffit, KennethOlah, EdithOlama, Ali Amin AlOlopade, Olufunmilayo IOlshan, Andrew FOlsson, HåkanOsorio, AnaPandha, HardevPark, Jong YPashayan, NoraParsons, Michael TPejovic, TanjaPenney, Kathryn LPeters, Wilbert H MPhelan, Catherine MPhipps, Amanda IPlaseska-Karanfilska, DijanaPring, MirandaProkofyeva, DaryaRadice, PaoloStefansson, KariRamus, Susan JRaskin, LeonRennert, GadRennert, Hedy Svan Rensburg, Elizabeth JRiggan, Marjorie JRisch, Harvey ARisch, AngelaRoobol, Monique JRosenstein, Barry SRossing, Mary AnneDe Ruyck, KimSaloustros, EmmanouilSandler, Dale PSawyer, Elinor JSchabath, Matthew BSchleutker, JohannaSchmidt, Marjanka KSetiawan, V WendyShen, HongbingSiegel, Erin MSieh, WeivaSinger, Christian FSlattery, Martha LSorensen, Karina DalsgaardSouthey, Melissa CSpurdle, Amanda BStanford, Janet LStevens, Victoria LStintzing, SebastianStone, JenniferSundfeldt, KarinSutphen, RebeccaSwerdlow, Anthony JTajara, Eloiza HTangen, Catherine MTardón, AdoninaTaylor, Jack ATeare, M DawnTeixeira, Manuel RTerry, Mary BethTerry, Kathryn LThibodeau, Stephen NThomassen, MadsBjørge, LineTischkowitz, MarcToland, Amanda ETorres, DianaTownsend, Paul ATravis, Ruth CTung, NadineTworoger, Shelley SUlrich, Cornelia MUsmani, NawaidVachon, Celine MVan Nieuwenhuysen, ElsVega, AnaAguado-Barrera, Miguel ElíasWang, QinWebb, Penelope MWeinberg, Clarice RWeinstein, StephanieWeissler, Mark CWeitzel, Jeffrey NWest, Catharine M LWhite, EmilyWhittemore, Alice SWichmann, H-ErichWiklund, FredrikWinqvist, RobertWolk, AlicjaWoll, PenellaWoods, MichaelWu, Anna HWu, XifengYannoukakos, DrakoulisZheng, WeiZienolddiny, ShanbehZiogas, ArgyriosZorn, Kristin KLane, Jacqueline MSaxena, RichaThomas, DuncanHung, Rayjean JDiergaarde, BrendaMcKay, JamesPeters, UlrikeHsu, LiGarcía-Closas, MontserratEeles, Rosalind AChenevix-Trench, GeorgiaBrennan, Paul JHaiman, Christopher ASimard, JacquesEaston, Douglas FGruber, Stephen BPharoah, Paul D PPrice, Alkes LPasaniuc, BogdanAmos, Christopher IKraft, PeterLindström, SaraBreast NeoplasmsCase-Control StudiesColorectal NeoplasmsEuropean Continental Ancestry GroupFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyQuantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.Nature Publishing GroupCancer Research UK (Reino Unido)NIHR - Comprehensive Biomedical Research CentreGuy ’ s & St. Thomas ’ NHS Foundation TrustNIHR - Oxford Biomedical Research Centre (Reino Unido)German Cancer Research CenterConsejo Nacional de Ciencia y Tecnología (México)King College LondonNational Health and Medical Research Council (Australia)Canadian Institutes of Health ResearchThe BREast Oncology GAlician Network (BREOGANDietmar-Hopp FoundationHelmholtz Society and the German Cancer Research Center (DKFZ)Asociación Española Contra el Cáncer20192019-04-2220192019-01-2520192019-01-25journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7477reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PI12 02125ES PI13 01136open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/74772026-06-12T12:43:37Z
score	15,811543

Shared heritability and functional enrichment across six solid cancers

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