Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila

© 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Detalhes bibliográficos
Autores: Silvestri, Alessandra, Gil-Gómez, Antonio, Vitale, Milena, Braga, Daniele, Demitri, Christian, Brescia, Paola, Madaghiele, Marta, Spadoni, Ilaria, Jones, Bryan, Fornasa, Giulia, Mouries, Juliette, Carloni, Sara, Lizier, Michela, Romero-Gómez, Manuel, Penna, Giuseppe, Sannino, Alessandro, Rescigno, Maria
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349788
Acesso em linha:http://hdl.handle.net/10261/349788
Access Level:acceso abierto
Palavra-chave:Microbiota
Obesity
Metabolic syndrome
Superabsorbent hydrogel
Akkermansia muciniphila
Gut health
Gut-liver axis
Intestinal barrier
Intestinal permeability
NAFLD
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spelling Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphilaSilvestri, AlessandraGil-Gómez, AntonioVitale, MilenaBraga, DanieleDemitri, ChristianBrescia, PaolaMadaghiele, MartaSpadoni, IlariaJones, BryanFornasa, GiuliaMouries, JulietteCarloni, SaraLizier, MichelaRomero-Gómez, ManuelPenna, GiuseppeSannino, AlessandroRescigno, MariaMicrobiotaObesityMetabolic syndromeSuperabsorbent hydrogelAkkermansia muciniphilaGut healthGut-liver axisIntestinal barrierIntestinal permeabilityNAFLD© 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).The rising prevalence of obesity and metabolic disorders worldwide highlights the urgent need to find new long-term and clinically meaningful weight-loss therapies. Here, we evaluate the therapeutic potential and the mechanism of action of a biomimetic cellulose-based oral superabsorbent hydrogel (OSH). Treatment with OSH exerts effects on intestinal tissue and gut microbiota composition, functioning like a protective dynamic exoskeleton. It protects from gut barrier permeability disruption and induces rapid and consistent changes in the gut microbiota composition, specifically fostering Akkermansia muciniphila expansion. The mechanobiological, physical, and chemical structures of the gel are required for A. muciniphila growth. OSH treatment induces weight loss and reduces fat accumulation, in both preventative and therapeutic settings. OSH usage also prevents liver steatosis, immune infiltration, and fibrosis, limiting the progression of non-alcoholic fatty liver disease. Our work shows the potential of using OSH as a non-systemic mechanobiological approach to treat metabolic syndrome and its comorbidities.The research leading to these results has received funding from Gelesis S.r.l.; Gelesis is a biotechnology company that develops novel therapies for gastrointestinal-related chronic diseases. We acknowledge a fellowship from the Consejería de Salud y Familias, Junta de Andalucía, to A.G.-G. (RH-122-2020).Peer reviewedCell PressGelesisJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/349788reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.xcrm.2023.101235Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3497882026-05-22T06:33:51Z
dc.title.none.fl_str_mv Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
title Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
spellingShingle Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
Silvestri, Alessandra
Microbiota
Obesity
Metabolic syndrome
Superabsorbent hydrogel
Akkermansia muciniphila
Gut health
Gut-liver axis
Intestinal barrier
Intestinal permeability
NAFLD
title_short Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
title_full Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
title_fullStr Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
title_full_unstemmed Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
title_sort Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila
dc.creator.none.fl_str_mv Silvestri, Alessandra
Gil-Gómez, Antonio
Vitale, Milena
Braga, Daniele
Demitri, Christian
Brescia, Paola
Madaghiele, Marta
Spadoni, Ilaria
Jones, Bryan
Fornasa, Giulia
Mouries, Juliette
Carloni, Sara
Lizier, Michela
Romero-Gómez, Manuel
Penna, Giuseppe
Sannino, Alessandro
Rescigno, Maria
author Silvestri, Alessandra
author_facet Silvestri, Alessandra
Gil-Gómez, Antonio
Vitale, Milena
Braga, Daniele
Demitri, Christian
Brescia, Paola
Madaghiele, Marta
Spadoni, Ilaria
Jones, Bryan
Fornasa, Giulia
Mouries, Juliette
Carloni, Sara
Lizier, Michela
Romero-Gómez, Manuel
Penna, Giuseppe
Sannino, Alessandro
Rescigno, Maria
author_role author
author2 Gil-Gómez, Antonio
Vitale, Milena
Braga, Daniele
Demitri, Christian
Brescia, Paola
Madaghiele, Marta
Spadoni, Ilaria
Jones, Bryan
Fornasa, Giulia
Mouries, Juliette
Carloni, Sara
Lizier, Michela
Romero-Gómez, Manuel
Penna, Giuseppe
Sannino, Alessandro
Rescigno, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Gelesis
Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Microbiota
Obesity
Metabolic syndrome
Superabsorbent hydrogel
Akkermansia muciniphila
Gut health
Gut-liver axis
Intestinal barrier
Intestinal permeability
NAFLD
topic Microbiota
Obesity
Metabolic syndrome
Superabsorbent hydrogel
Akkermansia muciniphila
Gut health
Gut-liver axis
Intestinal barrier
Intestinal permeability
NAFLD
description © 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/349788
url http://hdl.handle.net/10261/349788
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.xcrm.2023.101235
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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