UPR: An Upstream Signal to EMT Induction in Cancer

© 2019 by the authors.

Detalles Bibliográficos
Autores: Santamaría, Patricia G., Mazón, María J., Eraso, Pilar, Portillo, Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/207728
Acceso en línea:http://hdl.handle.net/10261/207728
Access Level:acceso abierto
Palabra clave:Epithelial-mesenchymal transition
Endoplasmic reticulum stress
Metastasis
Plasticity
Unfolded protein
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spelling UPR: An Upstream Signal to EMT Induction in CancerSantamaría, Patricia G.Mazón, María J.Eraso, PilarPortillo, FranciscoEpithelial-mesenchymal transitionEndoplasmic reticulum stressMetastasisPlasticityUnfolded protein© 2019 by the authors.The endoplasmic reticulum (ER) is the organelle where newly synthesized proteins enter the secretory pathway. Different physiological and pathological conditions may perturb the secretory capacity of cells and lead to the accumulation of misfolded and unfolded proteins. To relieve the produced stress, cells evoke an adaptive signalling network, the unfolded protein response (UPR), aimed at recovering protein homeostasis. Tumour cells must confront intrinsic and extrinsic pressures during cancer progression that produce a proteostasis imbalance and ER stress. To overcome this situation, tumour cells activate the UPR as a pro-survival mechanism. UPR activation has been documented in most types of human tumours and accumulating evidence supports a crucial role for UPR in the establishment, progression, metastasis and chemoresistance of tumours as well as its involvement in the acquisition of other hallmarks of cancer. In this review, we will analyse the role of UPR in cancer development highlighting the ability of tumours to exploit UPR signalling to promote epithelial-mesenchymal transition (EMT).This research was funded by the Spanish Ministerio de Economía y Competitividad (MICINN) (SAF2013-44739-R and SAF2016-76504-R, EU-FEDER funds), Instituto de Salud Carlos III (CIBERONC 16/12/00295, EU-FEDER funds), and Worldwide Cancer Research (AICR-12-1057 and WWCR-16-0295).Multidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)European CommissionInstituto de Salud Carlos IIIWorldwide Cancer ResearchConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/207728reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-44739-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76504-Rhttp://dx.doi.org/10.3390/jcm8050624Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2077282026-05-22T06:33:51Z
dc.title.none.fl_str_mv UPR: An Upstream Signal to EMT Induction in Cancer
title UPR: An Upstream Signal to EMT Induction in Cancer
spellingShingle UPR: An Upstream Signal to EMT Induction in Cancer
Santamaría, Patricia G.
Epithelial-mesenchymal transition
Endoplasmic reticulum stress
Metastasis
Plasticity
Unfolded protein
title_short UPR: An Upstream Signal to EMT Induction in Cancer
title_full UPR: An Upstream Signal to EMT Induction in Cancer
title_fullStr UPR: An Upstream Signal to EMT Induction in Cancer
title_full_unstemmed UPR: An Upstream Signal to EMT Induction in Cancer
title_sort UPR: An Upstream Signal to EMT Induction in Cancer
dc.creator.none.fl_str_mv Santamaría, Patricia G.
Mazón, María J.
Eraso, Pilar
Portillo, Francisco
author Santamaría, Patricia G.
author_facet Santamaría, Patricia G.
Mazón, María J.
Eraso, Pilar
Portillo, Francisco
author_role author
author2 Mazón, María J.
Eraso, Pilar
Portillo, Francisco
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Instituto de Salud Carlos III
Worldwide Cancer Research
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Epithelial-mesenchymal transition
Endoplasmic reticulum stress
Metastasis
Plasticity
Unfolded protein
topic Epithelial-mesenchymal transition
Endoplasmic reticulum stress
Metastasis
Plasticity
Unfolded protein
description © 2019 by the authors.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/207728
url http://hdl.handle.net/10261/207728
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
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info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-44739-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76504-R
http://dx.doi.org/10.3390/jcm8050624
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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