Differential trypanocidal activity of novel macrolide antibiotics; correlation to genetic lineage

Here we report the systematic study of the anti-trypanocidal activity of some new products derived from S. diastatus on 14 different T. cruzi strains spanning the six genetic lineages of T. cruzi. As the traditional growth inhibition curves giving similar IC 50 showed great differences on antibiotic...

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Detalles Bibliográficos
Autores: Aquilino, Carolina, González Rubio, María Luisa, Seco Martín, Elena María, Escudero, Leticia, Corvo, Laura, Soto, Manuel, Fresno, Manuel, Malpartida, Francisco, Bonay, Pedro
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/100642
Acceso en línea:http://hdl.handle.net/10261/100642
Access Level:acceso abierto
Descripción
Sumario:Here we report the systematic study of the anti-trypanocidal activity of some new products derived from S. diastatus on 14 different T. cruzi strains spanning the six genetic lineages of T. cruzi. As the traditional growth inhibition curves giving similar IC 50 showed great differences on antibiotic and lineage tested, we decided to preserve the wealth of information derived from each inhibition curve and used an algorithm related to potency of the drugs, combined in a matrix data set used to generate a cluster tree. The cluster thus generated based just on drug susceptibility data closely resembles the phylogenies of the lineages derived from genetic data and provides a novel approach to correlate genetic data with phenotypes related to pathogenesis of Chagas disease. Furthermore we provide clues on the drugs mechanism of action. © 2012 Aquilino et al.

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