Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial
IMPORTANCE: Breast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVE: To evaluate the effect of 2 interventi...
| Autores: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/118863 |
| Acceso en línea: | https://hdl.handle.net/2445/118863 |
| Access Level: | acceso abierto |
| Palabra clave: | Assaigs clínics Cuina mediterrània Medicina preventiva Càncer de mama Dones Clinical trials Mediterranean cooking Preventive medicine Breast cancer Women |
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Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trialToledo Atucha, EstefaníaSalas Salvadó, JordiDonat Vargas, CarolinaBuil Cosiales, PilarEstruch Riba, RamonRos Rahola, EmilioCorella Piquer, DoloresFitó Colomer, MontserratHu, Frank B.Arós, FernandoGómez Gracia, EnriqueRomaguera, DoraOrtega Calvo, ManuelSerra Majem, LluísPintó Sala, XavierSchröder, Helmut, 1958-Basora, JosepSorlí, José V.Bulló, MònicaSerra-Mir, MercèMartínez-González, Miguel Ángel, 1957-Assaigs clínicsCuina mediterràniaMedicina preventivaCàncer de mamaDonesClinical trialsMediterranean cookingPreventive medicineBreast cancerWomenIMPORTANCE: Breast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVE: To evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat diet (control) on breast cancer incidence. DESIGN, SETTING, AND PARTICIPANTS: The PREDIMED study is a 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 to 2009, 4282 women aged 60 to 80 years and at high cardiovascular disease risk were recruited after invitation by their primary care physicians. INTERVENTIONS: Participants were randomly allocated to a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURES: Breast cancer incidence was a prespecified secondary outcome of the trial for women without a prior history of breast cancer (n = 4152). RESULTS: After a median follow-up of 4.8 years, we identified 35 confirmed incident cases of breast cancer. Observed rates (per 1000 person-years) were 1.1 for the Mediterranean diet with extra-virgin olive oil group, 1.8 for the Mediterranean diet with nuts group, and 2.9 for the control group. The multivariable-adjusted hazard ratios vs the control group were 0.32 (95% CI, 0.13-0.79) for the Mediterranean diet with extra-virgin olive oil group and 0.59 (95% CI, 0.26-1.35) for the Mediterranean diet with nuts group. In analyses with yearly cumulative updated dietary exposures, the hazard ratio for each additional 5% of calories from extra-virgin olive oil was 0.72 (95% CI, 0.57-0.90). CONCLUSIONS AND RELEVANCE: This is the first randomized trial finding an effect of a long-term dietary intervention on breast cancer incidence. Our results suggest a beneficial effect of a Mediterranean diet supplemented with extra-virgin olive oil in the primary prevention of breast cancer. These results come from a secondary analysis of a previous trial and are based on few incident cases and, therefore, need to be confirmed in longer-term and larger studies.American Medical Association2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/118863Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1001/jamainternmed.2015.4838JAMA Internal Medicine, 2015, vol. 175, num. 11, p. 1752-1760https://doi.org/10.1001/jamainternmed.2015.4838(c) American Medical Association, 2015info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1188632026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial |
| title |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial |
| spellingShingle |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial Toledo Atucha, Estefanía Assaigs clínics Cuina mediterrània Medicina preventiva Càncer de mama Dones Clinical trials Mediterranean cooking Preventive medicine Breast cancer Women |
| title_short |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial |
| title_full |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial |
| title_fullStr |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial |
| title_full_unstemmed |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial |
| title_sort |
Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED Trial: A randomized clinical trial |
| dc.creator.none.fl_str_mv |
Toledo Atucha, Estefanía Salas Salvadó, Jordi Donat Vargas, Carolina Buil Cosiales, Pilar Estruch Riba, Ramon Ros Rahola, Emilio Corella Piquer, Dolores Fitó Colomer, Montserrat Hu, Frank B. Arós, Fernando Gómez Gracia, Enrique Romaguera, Dora Ortega Calvo, Manuel Serra Majem, Lluís Pintó Sala, Xavier Schröder, Helmut, 1958- Basora, Josep Sorlí, José V. Bulló, Mònica Serra-Mir, Mercè Martínez-González, Miguel Ángel, 1957- |
| author |
Toledo Atucha, Estefanía |
| author_facet |
Toledo Atucha, Estefanía Salas Salvadó, Jordi Donat Vargas, Carolina Buil Cosiales, Pilar Estruch Riba, Ramon Ros Rahola, Emilio Corella Piquer, Dolores Fitó Colomer, Montserrat Hu, Frank B. Arós, Fernando Gómez Gracia, Enrique Romaguera, Dora Ortega Calvo, Manuel Serra Majem, Lluís Pintó Sala, Xavier Schröder, Helmut, 1958- Basora, Josep Sorlí, José V. Bulló, Mònica Serra-Mir, Mercè Martínez-González, Miguel Ángel, 1957- |
| author_role |
author |
| author2 |
Salas Salvadó, Jordi Donat Vargas, Carolina Buil Cosiales, Pilar Estruch Riba, Ramon Ros Rahola, Emilio Corella Piquer, Dolores Fitó Colomer, Montserrat Hu, Frank B. Arós, Fernando Gómez Gracia, Enrique Romaguera, Dora Ortega Calvo, Manuel Serra Majem, Lluís Pintó Sala, Xavier Schröder, Helmut, 1958- Basora, Josep Sorlí, José V. Bulló, Mònica Serra-Mir, Mercè Martínez-González, Miguel Ángel, 1957- |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Assaigs clínics Cuina mediterrània Medicina preventiva Càncer de mama Dones Clinical trials Mediterranean cooking Preventive medicine Breast cancer Women |
| topic |
Assaigs clínics Cuina mediterrània Medicina preventiva Càncer de mama Dones Clinical trials Mediterranean cooking Preventive medicine Breast cancer Women |
| description |
IMPORTANCE: Breast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVE: To evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat diet (control) on breast cancer incidence. DESIGN, SETTING, AND PARTICIPANTS: The PREDIMED study is a 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 to 2009, 4282 women aged 60 to 80 years and at high cardiovascular disease risk were recruited after invitation by their primary care physicians. INTERVENTIONS: Participants were randomly allocated to a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURES: Breast cancer incidence was a prespecified secondary outcome of the trial for women without a prior history of breast cancer (n = 4152). RESULTS: After a median follow-up of 4.8 years, we identified 35 confirmed incident cases of breast cancer. Observed rates (per 1000 person-years) were 1.1 for the Mediterranean diet with extra-virgin olive oil group, 1.8 for the Mediterranean diet with nuts group, and 2.9 for the control group. The multivariable-adjusted hazard ratios vs the control group were 0.32 (95% CI, 0.13-0.79) for the Mediterranean diet with extra-virgin olive oil group and 0.59 (95% CI, 0.26-1.35) for the Mediterranean diet with nuts group. In analyses with yearly cumulative updated dietary exposures, the hazard ratio for each additional 5% of calories from extra-virgin olive oil was 0.72 (95% CI, 0.57-0.90). CONCLUSIONS AND RELEVANCE: This is the first randomized trial finding an effect of a long-term dietary intervention on breast cancer incidence. Our results suggest a beneficial effect of a Mediterranean diet supplemented with extra-virgin olive oil in the primary prevention of breast cancer. These results come from a secondary analysis of a previous trial and are based on few incident cases and, therefore, need to be confirmed in longer-term and larger studies. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/118863 |
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https://hdl.handle.net/2445/118863 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1001/jamainternmed.2015.4838 JAMA Internal Medicine, 2015, vol. 175, num. 11, p. 1752-1760 https://doi.org/10.1001/jamainternmed.2015.4838 |
| dc.rights.none.fl_str_mv |
(c) American Medical Association, 2015 info:eu-repo/semantics/openAccess |
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(c) American Medical Association, 2015 |
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openAccess |
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application/pdf |
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American Medical Association |
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American Medical Association |
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Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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