Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidom...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:289590 |
| Acceso en línea: | https://ddd.uab.cat/record/289590 https://dx.doi.org/urn:doi:10.3389/fimmu.2022.822272 |
| Access Level: | acceso abierto |
| Palabra clave: | Elite controllers (ECs) HIV infection Kreb's cycle Lipidomics Long-term Mass spectrometry Metabolomics Viral |
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| dc.title.none.fl_str_mv |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control |
| title |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control |
| spellingShingle |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control Masip, Jenifer|||0000-0002-9233-5195 Elite controllers (ECs) HIV infection Kreb's cycle Lipidomics Long-term Mass spectrometry Metabolomics Viral |
| title_short |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control |
| title_full |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control |
| title_fullStr |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control |
| title_full_unstemmed |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control |
| title_sort |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control |
| dc.creator.none.fl_str_mv |
Masip, Jenifer|||0000-0002-9233-5195 Rallón, Norma|||0000-0002-4643-247X Yeregui, Elena|||0000-0003-2994-4219 Olona, Montserrat|||0000-0001-5303-9361 Resino, Salvador|||0000-0001-8783-0450 Benito, José Miguel|||0000-0002-7172-049X Viladés, Consuelo|||0000-0002-2991-9593 García-Pardo, Graciano|||0000-0003-0274-6001 Alcami, Jose|||0000-0003-0023-7377 Ruiz-Mateos, Ezequiel|||0000-0001-6747-7813 Gómez-Bertomeu, Frederic Vargas Laguna, Montserrat|||0000-0001-7650-0587 Navarro Vilasaro, Marta|||0000-0002-3784-4405 Oteo, José A.|||0000-0001-7080-6542 Pineda, Juan A.|||0000-0002-3751-0296 Martí, Anna Alba, Verónica|||0000-0002-5925-9573 Vidal, Francesc|||0000-0002-6692-6186 Peraire, Joaquim|||0000-0001-7808-5479 Rull, Anna|||0000-0002-8907-7754 |
| author |
Masip, Jenifer|||0000-0002-9233-5195 |
| author_facet |
Masip, Jenifer|||0000-0002-9233-5195 Rallón, Norma|||0000-0002-4643-247X Yeregui, Elena|||0000-0003-2994-4219 Olona, Montserrat|||0000-0001-5303-9361 Resino, Salvador|||0000-0001-8783-0450 Benito, José Miguel|||0000-0002-7172-049X Viladés, Consuelo|||0000-0002-2991-9593 García-Pardo, Graciano|||0000-0003-0274-6001 Alcami, Jose|||0000-0003-0023-7377 Ruiz-Mateos, Ezequiel|||0000-0001-6747-7813 Gómez-Bertomeu, Frederic Vargas Laguna, Montserrat|||0000-0001-7650-0587 Navarro Vilasaro, Marta|||0000-0002-3784-4405 Oteo, José A.|||0000-0001-7080-6542 Pineda, Juan A.|||0000-0002-3751-0296 Martí, Anna Alba, Verónica|||0000-0002-5925-9573 Vidal, Francesc|||0000-0002-6692-6186 Peraire, Joaquim|||0000-0001-7808-5479 Rull, Anna|||0000-0002-8907-7754 |
| author_role |
author |
| author2 |
Rallón, Norma|||0000-0002-4643-247X Yeregui, Elena|||0000-0003-2994-4219 Olona, Montserrat|||0000-0001-5303-9361 Resino, Salvador|||0000-0001-8783-0450 Benito, José Miguel|||0000-0002-7172-049X Viladés, Consuelo|||0000-0002-2991-9593 García-Pardo, Graciano|||0000-0003-0274-6001 Alcami, Jose|||0000-0003-0023-7377 Ruiz-Mateos, Ezequiel|||0000-0001-6747-7813 Gómez-Bertomeu, Frederic Vargas Laguna, Montserrat|||0000-0001-7650-0587 Navarro Vilasaro, Marta|||0000-0002-3784-4405 Oteo, José A.|||0000-0001-7080-6542 Pineda, Juan A.|||0000-0002-3751-0296 Martí, Anna Alba, Verónica|||0000-0002-5925-9573 Vidal, Francesc|||0000-0002-6692-6186 Peraire, Joaquim|||0000-0001-7808-5479 Rull, Anna|||0000-0002-8907-7754 |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Elite controllers (ECs) HIV infection Kreb's cycle Lipidomics Long-term Mass spectrometry Metabolomics Viral |
| topic |
Elite controllers (ECs) HIV infection Kreb's cycle Lipidomics Long-term Mass spectrometry Metabolomics Viral |
| description |
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunological HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF] in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunological control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunological control (less than 5 years; no-LTEC patients). Long-term viral and immunological HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biological processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/289590 https://dx.doi.org/urn:doi:10.3389/fimmu.2022.822272 |
| url |
https://ddd.uab.cat/record/289590 https://dx.doi.org/urn:doi:10.3389/fimmu.2022.822272 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00004 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01127 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01337 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00973 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00326 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0006 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0013 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0020 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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1869412050546982912 |
| spelling |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV ControlMasip, Jenifer|||0000-0002-9233-5195Rallón, Norma|||0000-0002-4643-247XYeregui, Elena|||0000-0003-2994-4219Olona, Montserrat|||0000-0001-5303-9361Resino, Salvador|||0000-0001-8783-0450Benito, José Miguel|||0000-0002-7172-049XViladés, Consuelo|||0000-0002-2991-9593García-Pardo, Graciano|||0000-0003-0274-6001Alcami, Jose|||0000-0003-0023-7377Ruiz-Mateos, Ezequiel|||0000-0001-6747-7813Gómez-Bertomeu, FredericVargas Laguna, Montserrat|||0000-0001-7650-0587Navarro Vilasaro, Marta|||0000-0002-3784-4405Oteo, José A.|||0000-0001-7080-6542Pineda, Juan A.|||0000-0002-3751-0296Martí, AnnaAlba, Verónica|||0000-0002-5925-9573Vidal, Francesc|||0000-0002-6692-6186Peraire, Joaquim|||0000-0001-7808-5479Rull, Anna|||0000-0002-8907-7754Elite controllers (ECs)HIV infectionKreb's cycleLipidomicsLong-termMass spectrometryMetabolomicsViralLong-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunological HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF] in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunological control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunological control (less than 5 years; no-LTEC patients). Long-term viral and immunological HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biological processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/289590https://dx.doi.org/urn:doi:10.3389/fimmu.2022.822272reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00004Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01127Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01337Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00973Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00326Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0006Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0013Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0020open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2895902026-06-06T12:50:31Z |
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15.301603 |