Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population

Background and aim Albuminuria is an indicator of sub-clinical organ damage and a marker of cardiovascular risk and renal disease. A percentage of hypertensive patients develop albuminuria despite being under chronic suppression of the renin-angiotensin system (RAS). We previously identified urinary...

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Autores: Santiago Hernández, Aranzazu, Martínez, Paula J., Martín Lorenzo, Marta, Ruiz Hurtado, Gema, Barderas, María G., Segura, Julián, Ruilope Urioste, Luis Miguel, Álvarez Llamas, Gloria
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/9736
Acceso en línea:http://hdl.handle.net/11268/9736
Access Level:acceso abierto
Palabra clave:Enfermedades cardiovasculares
Albuminuria
Metabolismo
Enfermedad cardiovascular
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spelling Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive populationPerfil metabolómico diferenciador asociado a la condición de normoalbuminuria en la población hipertensaSantiago Hernández, AranzazuMartínez, Paula J.Martín Lorenzo, MartaRuiz Hurtado, GemaBarderas, María G.Segura, JuliánRuilope Urioste, Luis MiguelÁlvarez Llamas, GloriaEnfermedades cardiovascularesAlbuminuriaMetabolismoEnfermedad cardiovascularMetabolismoBackground and aim Albuminuria is an indicator of sub-clinical organ damage and a marker of cardiovascular risk and renal disease. A percentage of hypertensive patients develop albuminuria despite being under chronic suppression of the renin-angiotensin system (RAS). We previously identified urinary metabolites associated with the development of albuminuria. In this study, we searched for metabolic alterations which reflect different levels within the condition of normoalbuminuria. Patients, materials and methods Urine from 48 hypertensive patients under chronic RAS suppression was analyzed. They were classified according to the albumin / creatinine ratio (ACR) into 3 groups: Normoalbuminuria (<10 mg / g); Normal-high (10–30 mg / g in men, or 20−40 mg / g in women); and moderately high albuminuria (microalbuminuria, 30−200 mg / g or 40−300 mg / g, respectively). The metabolome was analyzed by mass spectrometry and a correlation analysis was performed between altered metabolite levels and ACR. Results Oxaloacetate, 3-ureidopropionate, guanidoacetate and malate show significant variation between the normo and micro groups. Additionally, these metabolites are able to differentiate between patients in the normo and high-normal range. A significant correlation between metabolites and ACR was found. Observed variations point to alterations in the energy metabolism already in patients with albuminuria in the high-normal range. Conclusions The association between the molecular panel consisting of 3-reidopropionate, oxaloacetate, malate and guanidoacetate and different levels of albuminuria is confirmed. A metabolic fingerprint was also identified showing variations within the condition of normoalbuminuria allowing an earlier molecular stratification of patients.20212021-01-1920202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/9736reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/97362026-06-11T12:41:27Z
dc.title.none.fl_str_mv Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
Perfil metabolómico diferenciador asociado a la condición de normoalbuminuria en la población hipertensa
title Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
spellingShingle Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
Santiago Hernández, Aranzazu
Enfermedades cardiovasculares
Albuminuria
Metabolismo
Enfermedad cardiovascular
Metabolismo
title_short Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
title_full Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
title_fullStr Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
title_full_unstemmed Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
title_sort Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
dc.creator.none.fl_str_mv Santiago Hernández, Aranzazu
Martínez, Paula J.
Martín Lorenzo, Marta
Ruiz Hurtado, Gema
Barderas, María G.
Segura, Julián
Ruilope Urioste, Luis Miguel
Álvarez Llamas, Gloria
author Santiago Hernández, Aranzazu
author_facet Santiago Hernández, Aranzazu
Martínez, Paula J.
Martín Lorenzo, Marta
Ruiz Hurtado, Gema
Barderas, María G.
Segura, Julián
Ruilope Urioste, Luis Miguel
Álvarez Llamas, Gloria
author_role author
author2 Martínez, Paula J.
Martín Lorenzo, Marta
Ruiz Hurtado, Gema
Barderas, María G.
Segura, Julián
Ruilope Urioste, Luis Miguel
Álvarez Llamas, Gloria
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Enfermedades cardiovasculares
Albuminuria
Metabolismo
Enfermedad cardiovascular
Metabolismo
topic Enfermedades cardiovasculares
Albuminuria
Metabolismo
Enfermedad cardiovascular
Metabolismo
description Background and aim Albuminuria is an indicator of sub-clinical organ damage and a marker of cardiovascular risk and renal disease. A percentage of hypertensive patients develop albuminuria despite being under chronic suppression of the renin-angiotensin system (RAS). We previously identified urinary metabolites associated with the development of albuminuria. In this study, we searched for metabolic alterations which reflect different levels within the condition of normoalbuminuria. Patients, materials and methods Urine from 48 hypertensive patients under chronic RAS suppression was analyzed. They were classified according to the albumin / creatinine ratio (ACR) into 3 groups: Normoalbuminuria (<10 mg / g); Normal-high (10–30 mg / g in men, or 20−40 mg / g in women); and moderately high albuminuria (microalbuminuria, 30−200 mg / g or 40−300 mg / g, respectively). The metabolome was analyzed by mass spectrometry and a correlation analysis was performed between altered metabolite levels and ACR. Results Oxaloacetate, 3-ureidopropionate, guanidoacetate and malate show significant variation between the normo and micro groups. Additionally, these metabolites are able to differentiate between patients in the normo and high-normal range. A significant correlation between metabolites and ACR was found. Observed variations point to alterations in the energy metabolism already in patients with albuminuria in the high-normal range. Conclusions The association between the molecular panel consisting of 3-reidopropionate, oxaloacetate, malate and guanidoacetate and different levels of albuminuria is confirmed. A metabolic fingerprint was also identified showing variations within the condition of normoalbuminuria allowing an earlier molecular stratification of patients.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
2021
2021-01-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/9736
url http://hdl.handle.net/11268/9736
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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