A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes

The following article appeared in Inorganic Chemistry Frontiers 2 (2015): 75-84 and may be found at http://dx.doi.org/10.1039/C4QI00128A, reproduced by permission of The Royal Society of Chemistry

Detalhes bibliográficos
Autores: Matesanz García, Ana Isabel, Albacete, P., Perles, Josefina, Souza, Pilar
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/665382
Acesso em linha:http://hdl.handle.net/10486/665382
https://dx.doi.org/10.1039/C4QI00128A
Access Level:acceso abierto
Palavra-chave:Química
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spelling A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexesMatesanz García, Ana IsabelAlbacete, P.Perles, JosefinaSouza, PilarQuímicaThe following article appeared in Inorganic Chemistry Frontiers 2 (2015): 75-84 and may be found at http://dx.doi.org/10.1039/C4QI00128A, reproduced by permission of The Royal Society of ChemistryPreparation and characterization of the new ligand 3,5-diacetyl-1,2,4-triazol bis(4N-p -chlorophenylthiosemicarbazone), H5L1, and its bimetallic complexes [Pd(µ-H3L1)]2 and [Pt(µ-H3L1)]2, is described. The molecular structure of the complexes, determined by single crystal X-ray crystallography, reveals that each ligand coordinates, in an asymmetric dideprotonate form, to the metal ions in a square planar geometry. The new compounds synthesized have been evaluated for antiproliferative activity in vitro against NCI-H460, T-47D, A2780 and A2780cis R human cancer cell lines. The cytotoxicity data suggest that these compounds may be endowed with important antitumor properties, especially H5L1 since exhibit excellent antiproliferative activity surpassing the activity of cisplatin against three of the four tumor cell lines studied. The DNA binding ability of H5L1 and [Pt(µ-H3L1)]2 with calf thymus DNA in Tris-HCl buffer solution (pH=7.2) was explored by UV-Vis absorption spectroscopy and viscosity measurements. These data indicated that both compounds bind to DNA by a groove binding modeWe are grateful to Ministerio de Economía y Competitividad, Instituto de Salud Carlos III (PI1100659), of Spain for financial supportRoyal Society of ChemistryDepartamento de Química InorgánicaFacultad de Ciencias20142014-11-19research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/665382https://dx.doi.org/10.1039/C4QI00128Areponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6653822026-06-23T12:46:27Z
dc.title.none.fl_str_mv A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
title A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
spellingShingle A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
Matesanz García, Ana Isabel
Química
title_short A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
title_full A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
title_fullStr A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
title_full_unstemmed A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
title_sort A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes
dc.creator.none.fl_str_mv Matesanz García, Ana Isabel
Albacete, P.
Perles, Josefina
Souza, Pilar
author Matesanz García, Ana Isabel
author_facet Matesanz García, Ana Isabel
Albacete, P.
Perles, Josefina
Souza, Pilar
author_role author
author2 Albacete, P.
Perles, Josefina
Souza, Pilar
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Química Inorgánica
Facultad de Ciencias
dc.subject.none.fl_str_mv Química
topic Química
description The following article appeared in Inorganic Chemistry Frontiers 2 (2015): 75-84 and may be found at http://dx.doi.org/10.1039/C4QI00128A, reproduced by permission of The Royal Society of Chemistry
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-11-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/665382
https://dx.doi.org/10.1039/C4QI00128A
url http://hdl.handle.net/10486/665382
https://dx.doi.org/10.1039/C4QI00128A
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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