Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome

Introduction: Individuals with Down syndrome (DS) are at an ultra-high risk of developing Alzheimer's disease (AD). Diagnosis of AD onset in people with DS can be challenging due to the variable degrees of intellectual disability and cognitive impairment among individuals. Methods: Plasma sampl...

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Autores: Ledreux, A, Carmona-Iragui, M, Videla, L, Benejam, B, Barroeta, I, Lleó, A, Alcolea, D, Fortea, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19821
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19821
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
amyloid-beta
biomarker
dementia
Down syndrome
extracellular vesicle
neurofilament-light
phosphorylated Tau
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spelling Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndromeLedreux, ACarmona-Iragui, MVidela, LBenejam, BBarroeta, ILleó, AAlcolea, DFortea, JAlzheimer's diseaseamyloid-betabiomarkerdementiaDown syndromeextracellular vesicleneurofilament-lightphosphorylated TauIntroduction: Individuals with Down syndrome (DS) are at an ultra-high risk of developing Alzheimer's disease (AD). Diagnosis of AD onset in people with DS can be challenging due to the variable degrees of intellectual disability and cognitive impairment among individuals. Methods: Plasma samples from individuals with DS diagnosed with AD dementia (n = 33), prodromal AD (n = 31), or cognitively stable (n = 43) were enriched for neuron-derived extracellular vesicles (NDEV) using immunocapture with the L1CAM antibody. We used single-molecule array technology to quantify amyloid-beta (A beta) peptides, Tau, phosphorylated Tau, neurofilament light chain (NfL), and synaptosomal-associated protein 25 (SNAP25) across diagnostic groups. Results: NDEV levels of A beta 40, A beta 42, Tau, pTauT181, pTauT231, NfL, and SNAP25 were significantly higher in people with DS diagnosed with prodromal AD compared to those with no cognitive decline. Middle-aged or older women had higher levels of NDEV biomarkers compared to males. Discussion: NDEV biomarker levels can inform on the onset of AD in individuals with DS.WILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19821ALZHEIMERS & DEMENTIAISSN: 15525260ISSNe: 15525279reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p198212026-06-14T12:41:47Z
dc.title.none.fl_str_mv Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
title Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
spellingShingle Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
Ledreux, A
Alzheimer's disease
amyloid-beta
biomarker
dementia
Down syndrome
extracellular vesicle
neurofilament-light
phosphorylated Tau
title_short Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
title_full Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
title_fullStr Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
title_full_unstemmed Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
title_sort Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
dc.creator.none.fl_str_mv Ledreux, A
Carmona-Iragui, M
Videla, L
Benejam, B
Barroeta, I
Lleó, A
Alcolea, D
Fortea, J
author Ledreux, A
author_facet Ledreux, A
Carmona-Iragui, M
Videla, L
Benejam, B
Barroeta, I
Lleó, A
Alcolea, D
Fortea, J
author_role author
author2 Carmona-Iragui, M
Videla, L
Benejam, B
Barroeta, I
Lleó, A
Alcolea, D
Fortea, J
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer's disease
amyloid-beta
biomarker
dementia
Down syndrome
extracellular vesicle
neurofilament-light
phosphorylated Tau
topic Alzheimer's disease
amyloid-beta
biomarker
dementia
Down syndrome
extracellular vesicle
neurofilament-light
phosphorylated Tau
description Introduction: Individuals with Down syndrome (DS) are at an ultra-high risk of developing Alzheimer's disease (AD). Diagnosis of AD onset in people with DS can be challenging due to the variable degrees of intellectual disability and cognitive impairment among individuals. Methods: Plasma samples from individuals with DS diagnosed with AD dementia (n = 33), prodromal AD (n = 31), or cognitively stable (n = 43) were enriched for neuron-derived extracellular vesicles (NDEV) using immunocapture with the L1CAM antibody. We used single-molecule array technology to quantify amyloid-beta (A beta) peptides, Tau, phosphorylated Tau, neurofilament light chain (NfL), and synaptosomal-associated protein 25 (SNAP25) across diagnostic groups. Results: NDEV levels of A beta 40, A beta 42, Tau, pTauT181, pTauT231, NfL, and SNAP25 were significantly higher in people with DS diagnosed with prodromal AD compared to those with no cognitive decline. Middle-aged or older women had higher levels of NDEV biomarkers compared to males. Discussion: NDEV biomarker levels can inform on the onset of AD in individuals with DS.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19821
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19821
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv ALZHEIMERS & DEMENTIA
ISSN: 15525260
ISSNe: 15525279
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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