Synthesis and properties of Poly(L-lactide)-b-poly (L-phenylalanine) hybrid copolymers
Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(L-lactide-b-L-phenylalanine) copo...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/24851 |
| Acceso en línea: | https://hdl.handle.net/2117/24851 https://dx.doi.org/10.3390/ijms150813247 |
| Access Level: | acceso abierto |
| Palabra clave: | Polymers--Biodegradation Ring-opening polymerization biodegradable polymers block copolymers self-assembly polylactide polyphenylalanine ring-opening polymerization SELF-ASSEMBLY PROPERTIES BLOCK-COPOLYMERS N-CARBOXYANHYDRIDES TRIBLOCK COPOLYMER ACID) POLYLACTIDE PEPTIDE POLYMERIZATION POLYPEPTIDES POLYMERS Polímers -- Biodegradació Polimerització -- Anàlisi Àrees temàtiques de la UPC::Enginyeria química |
| Sumario: | Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(L-lactide-b-L-phenylalanine) copolymers with various block lengths were synthesized by sequential ring-opening polymerization of L-lactide and the N-carboxyanhydride of L-phenylalanine. The resulting block copolymers were characterized by NMR spectrometry, IR spectroscopy, gel permeation chromatography, MALDI-TOF and UV-vis, revealing the successful incorporation of the polyphenylalanine (PPhe) peptide into the previously formed poly(L-lactide) (PLLA) polymer chain. X-ray diffraction and DSC data also suggested that the copolymers were phase-separated in domains containing either crystalline PLLA or PPhe phases. A peculiar thermal behavior was also found by thermogravimetric analysis when polyphenylalanine blocks were incorporated into polylactide. |
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