A multicatalytic cascade for the stereoselective synthesis of 1,4-chiral nitro alcohols
Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-nitro alcohols bearing two stereocenters. Optimization of each...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:dnet:digitalcsic_::fe4f05c1ad1ad5eec7753090eb6f599b |
| Acceso en línea: | http://hdl.handle.net/10261/427112 |
| Access Level: | acceso abierto |
| Sumario: | Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-nitro alcohols bearing two stereocenters. Optimization of each step enabled the efficient and selective formation of all four diastereomers with excellent stereoselectivity (up to 97:3 dr and er) and good yields. This work highlights the potential of multicatalytic cascades for the synthesis of stereochemically rich molecules. |
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