Genetic structure of North African human populations : A complex history of admixture
North African populations show a complex genetic structure characterized by the admixture of at least four different components: Middle Eastern, sub-Saharan, European and autochthonous North African. However, there are few genome-wide studies focused on North Africa and only two Berber groups have b...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/664729 |
| Acceso en línea: | http://hdl.handle.net/10803/664729 |
| Access Level: | acceso abierto |
| Palabra clave: | North Africa Berbers Population Genetics Admixture Norte de África Bereberes Génetica de Poblaciones mezcla 575 |
| Sumario: | North African populations show a complex genetic structure characterized by the admixture of at least four different components: Middle Eastern, sub-Saharan, European and autochthonous North African. However, there are few genome-wide studies focused on North Africa and only two Berber groups have been included in those analyses. In this thesis genotype array data that increases the number of available Berber samples is introduced. This data shows a heterogenous genetic structure of North African populations, including Berbers, and a lack of genetic differentiation between Berber and Arab groups. Admixture is the main process shaping North African diversity. In the results of this thesis different admixture events are described, mainly related to sub-Saharan gene-flow and Middle Eastern expansions. Furthermore, North African gene-flow into coastal surrounding populations is analyzed, showing a recent historical North African contribution from different geographical places in the European coast and the Canary Islands populations. |
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