Validation of the neuroconnective endophenotype questionnaire (NEQ)

The link between anxiety disorders and joint hypermobility syndrome (now under hypermobility spectrum disorders, which include hypermobile Ehlers-Danlos syndrome) has been widely replicated over the past 30 years and has grown beyond the initial nosological limits. To integrate clinical and research...

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Autores: Bulbena Vilarrasa, Antonio|||0000-0003-2404-2478, Rosado, Silvia|||0000-0002-0871-3182, Cabaleiro, Marina, Martinez, María, Baeza-Velasco, Carolina, Martin, Luis-Miguel, Batlle-Vila, Santiago|||0000-0003-3657-3719, Bulbena-Cabre, Andrea|||0000-0001-7070-2014
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283015
Acceso en línea:https://ddd.uab.cat/record/283015
https://dx.doi.org/urn:doi:10.3389/fmed.2023.1039223
Access Level:acceso abierto
Palabra clave:Ehlers-Danlos syndrome
Anxiety
Psychosomatic medicine
Reliability
Validity
Joint hypermobility
Neuroconnective endophenotype
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spelling Validation of the neuroconnective endophenotype questionnaire (NEQ)a new clinical tool for medicine and psychiatry resulting from the contribution of Ehlers-Danlos syndromeBulbena Vilarrasa, Antonio|||0000-0003-2404-2478Rosado, Silvia|||0000-0002-0871-3182Cabaleiro, MarinaMartinez, MaríaBaeza-Velasco, CarolinaMartin, Luis-MiguelBatlle-Vila, Santiago|||0000-0003-3657-3719Bulbena-Cabre, Andrea|||0000-0001-7070-2014Ehlers-Danlos syndromeAnxietyPsychosomatic medicineReliabilityValidityJoint hypermobilityNeuroconnective endophenotypeThe link between anxiety disorders and joint hypermobility syndrome (now under hypermobility spectrum disorders, which include hypermobile Ehlers-Danlos syndrome) has been widely replicated over the past 30 years and has grown beyond the initial nosological limits. To integrate clinical and research progress in this field, a new neuroconnective endophenotype (NE) and its corresponding instrument, the Neuroconnective Endophenotype Questionnaire (NEQ), have been developed. This new clinical construct, created with the active participation of patients, includes both somatic and psychological dimensions and symptoms and resilience items. The NE includes five dimensions: (1) sensorial sensitivity, (2) body signs and symptoms, (3) somatic conditions, (4) polar behavioral strategies, and (5) psychological and psychopathological dimensions. The NEQ information is collected through four self-administered questionnaires (sensorial sensitivity, body signs and symptoms, polar behavioral strategies, and psychological characteristics) and a structured diagnostic part that should be completed by a trained observer. This hetero-administered part incorporates (a) psychiatric diagnoses (using structured criteria, e.g., MINI), (b) somatic disorders diagnosis, using structured criteria, and (c) assessment of joint hypermobility criteria. In a sample of 36 anxiety cases with 36 matched controls, the NEQ obtained high scores for test-retest, inter-rater reliability, and internal consistency. As for predictive validity, cases and controls significantly differed in all five dimensions and hypermobility measurements. We can conclude that the NEQ has achieved acceptable reliability and validity values and, therefore, is ready to be used and tested in different samples. This original and consistent construct including somatic and mental items may improve clinical specificity, the search for more comprehensive therapies, and their genetic and neuroimaging bases. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/283015https://dx.doi.org/urn:doi:10.3389/fmed.2023.1039223reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2830152026-06-06T12:50:31Z
dc.title.none.fl_str_mv Validation of the neuroconnective endophenotype questionnaire (NEQ)
a new clinical tool for medicine and psychiatry resulting from the contribution of Ehlers-Danlos syndrome
title Validation of the neuroconnective endophenotype questionnaire (NEQ)
spellingShingle Validation of the neuroconnective endophenotype questionnaire (NEQ)
Bulbena Vilarrasa, Antonio|||0000-0003-2404-2478
Ehlers-Danlos syndrome
Anxiety
Psychosomatic medicine
Reliability
Validity
Joint hypermobility
Neuroconnective endophenotype
title_short Validation of the neuroconnective endophenotype questionnaire (NEQ)
title_full Validation of the neuroconnective endophenotype questionnaire (NEQ)
title_fullStr Validation of the neuroconnective endophenotype questionnaire (NEQ)
title_full_unstemmed Validation of the neuroconnective endophenotype questionnaire (NEQ)
title_sort Validation of the neuroconnective endophenotype questionnaire (NEQ)
dc.creator.none.fl_str_mv Bulbena Vilarrasa, Antonio|||0000-0003-2404-2478
Rosado, Silvia|||0000-0002-0871-3182
Cabaleiro, Marina
Martinez, María
Baeza-Velasco, Carolina
Martin, Luis-Miguel
Batlle-Vila, Santiago|||0000-0003-3657-3719
Bulbena-Cabre, Andrea|||0000-0001-7070-2014
author Bulbena Vilarrasa, Antonio|||0000-0003-2404-2478
author_facet Bulbena Vilarrasa, Antonio|||0000-0003-2404-2478
Rosado, Silvia|||0000-0002-0871-3182
Cabaleiro, Marina
Martinez, María
Baeza-Velasco, Carolina
Martin, Luis-Miguel
Batlle-Vila, Santiago|||0000-0003-3657-3719
Bulbena-Cabre, Andrea|||0000-0001-7070-2014
author_role author
author2 Rosado, Silvia|||0000-0002-0871-3182
Cabaleiro, Marina
Martinez, María
Baeza-Velasco, Carolina
Martin, Luis-Miguel
Batlle-Vila, Santiago|||0000-0003-3657-3719
Bulbena-Cabre, Andrea|||0000-0001-7070-2014
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ehlers-Danlos syndrome
Anxiety
Psychosomatic medicine
Reliability
Validity
Joint hypermobility
Neuroconnective endophenotype
topic Ehlers-Danlos syndrome
Anxiety
Psychosomatic medicine
Reliability
Validity
Joint hypermobility
Neuroconnective endophenotype
description The link between anxiety disorders and joint hypermobility syndrome (now under hypermobility spectrum disorders, which include hypermobile Ehlers-Danlos syndrome) has been widely replicated over the past 30 years and has grown beyond the initial nosological limits. To integrate clinical and research progress in this field, a new neuroconnective endophenotype (NE) and its corresponding instrument, the Neuroconnective Endophenotype Questionnaire (NEQ), have been developed. This new clinical construct, created with the active participation of patients, includes both somatic and psychological dimensions and symptoms and resilience items. The NE includes five dimensions: (1) sensorial sensitivity, (2) body signs and symptoms, (3) somatic conditions, (4) polar behavioral strategies, and (5) psychological and psychopathological dimensions. The NEQ information is collected through four self-administered questionnaires (sensorial sensitivity, body signs and symptoms, polar behavioral strategies, and psychological characteristics) and a structured diagnostic part that should be completed by a trained observer. This hetero-administered part incorporates (a) psychiatric diagnoses (using structured criteria, e.g., MINI), (b) somatic disorders diagnosis, using structured criteria, and (c) assessment of joint hypermobility criteria. In a sample of 36 anxiety cases with 36 matched controls, the NEQ obtained high scores for test-retest, inter-rater reliability, and internal consistency. As for predictive validity, cases and controls significantly differed in all five dimensions and hypermobility measurements. We can conclude that the NEQ has achieved acceptable reliability and validity values and, therefore, is ready to be used and tested in different samples. This original and consistent construct including somatic and mental items may improve clinical specificity, the search for more comprehensive therapies, and their genetic and neuroimaging bases.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/283015
https://dx.doi.org/urn:doi:10.3389/fmed.2023.1039223
url https://ddd.uab.cat/record/283015
https://dx.doi.org/urn:doi:10.3389/fmed.2023.1039223
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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