The genetic impact of an Ebola outbreak on a wild gorilla population

Background Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in the...

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Autores: Fontsere, Claudia, Frandsen, Peter, Hernandez-Rodriguez, Jessica, Niemann, Jonas, Scharff-Olsen, Camilla Hjorth, Vallet, Dominique, Le Gouar, Pascaline, Menard, Nelly, Navarro, Arcadi, Siegismund, Hans R., Hvilsom, Christina, Gilbert, M. Thomas P., Kuhlwilm, Martin, Hughes, David, Marques-Bonet, Tomas
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19858
Acceso en línea:https://hdl.handle.net/20.500.13003/19858
Access Level:acceso abierto
Palabra clave:Gastrointestinal Microbiome
Disease Outbreaks
Gorilla gorilla
Hemorrhagic Fever, Ebola
Pan troglodytes
Animals
Humans
Animales
Humanos
Fiebre Hemorrágica Ebola
Microbioma Gastrointestinal
Brotes de Enfermedades
Ebola
gorilla
non-invasive samples
candidate genes
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spelling The genetic impact of an Ebola outbreak on a wild gorilla populationFontsere, ClaudiaFrandsen, PeterHernandez-Rodriguez, JessicaNiemann, JonasScharff-Olsen, Camilla HjorthVallet, DominiqueLe Gouar, PascalineMenard, NellyNavarro, ArcadiSiegismund, Hans R.Hvilsom, ChristinaGilbert, M. Thomas P.Kuhlwilm, MartinHughes, DavidMarques-Bonet, TomasGastrointestinal MicrobiomeDisease OutbreaksGorilla gorillaHemorrhagic Fever, EbolaPan troglodytesAnimalsHumansAnimalesGorilla gorillaHumanosPan troglodytesFiebre Hemorrágica EbolaMicrobioma GastrointestinalBrotes de EnfermedadesEbolagorillanon-invasive samplescandidate genesBackground Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in the resident western lowland gorilla (Gorilla gorilla gorilla) population, with a 95% mortality rate. Here, we explore the immediate genetic impact of the Ebola outbreak in the western lowland gorilla population. Results Associations with survivorship were evaluated by utilizing DNA obtained from fecal samples from 16 gorilla individuals declared missing after the outbreak (non-survivors) and 15 individuals observed before and after the epidemic (survivors). We used a target enrichment approach to capture the sequences of 123 genes previously associated with immunology and Ebola virus resistance and additionally analyzed the gut microbiome which could influence the survival after an infection. Our results indicate no changes in the population genetic diversity before and after the Ebola outbreak, and no significant differences in microbial community composition between survivors and non-survivors. However, and despite the low power for an association analysis, we do detect six nominally significant missense mutations in four genes that might be candidate variants associated with an increased chance of survival. Conclusion This study offers the first insight to the genetics of a wild great ape population before and after an Ebola outbreak using target capture experiments from fecal samples, and presents a list of candidate loci that may have facilitated their survival.BMC20212021-10-1120212021-10-11research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19858reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/198582026-06-22T12:44:07Z
dc.title.none.fl_str_mv The genetic impact of an Ebola outbreak on a wild gorilla population
title The genetic impact of an Ebola outbreak on a wild gorilla population
spellingShingle The genetic impact of an Ebola outbreak on a wild gorilla population
Fontsere, Claudia
Gastrointestinal Microbiome
Disease Outbreaks
Gorilla gorilla
Hemorrhagic Fever, Ebola
Pan troglodytes
Animals
Humans
Animales
Gorilla gorilla
Humanos
Pan troglodytes
Fiebre Hemorrágica Ebola
Microbioma Gastrointestinal
Brotes de Enfermedades
Ebola
gorilla
non-invasive samples
candidate genes
title_short The genetic impact of an Ebola outbreak on a wild gorilla population
title_full The genetic impact of an Ebola outbreak on a wild gorilla population
title_fullStr The genetic impact of an Ebola outbreak on a wild gorilla population
title_full_unstemmed The genetic impact of an Ebola outbreak on a wild gorilla population
title_sort The genetic impact of an Ebola outbreak on a wild gorilla population
dc.creator.none.fl_str_mv Fontsere, Claudia
Frandsen, Peter
Hernandez-Rodriguez, Jessica
Niemann, Jonas
Scharff-Olsen, Camilla Hjorth
Vallet, Dominique
Le Gouar, Pascaline
Menard, Nelly
Navarro, Arcadi
Siegismund, Hans R.
Hvilsom, Christina
Gilbert, M. Thomas P.
Kuhlwilm, Martin
Hughes, David
Marques-Bonet, Tomas
author Fontsere, Claudia
author_facet Fontsere, Claudia
Frandsen, Peter
Hernandez-Rodriguez, Jessica
Niemann, Jonas
Scharff-Olsen, Camilla Hjorth
Vallet, Dominique
Le Gouar, Pascaline
Menard, Nelly
Navarro, Arcadi
Siegismund, Hans R.
Hvilsom, Christina
Gilbert, M. Thomas P.
Kuhlwilm, Martin
Hughes, David
Marques-Bonet, Tomas
author_role author
author2 Frandsen, Peter
Hernandez-Rodriguez, Jessica
Niemann, Jonas
Scharff-Olsen, Camilla Hjorth
Vallet, Dominique
Le Gouar, Pascaline
Menard, Nelly
Navarro, Arcadi
Siegismund, Hans R.
Hvilsom, Christina
Gilbert, M. Thomas P.
Kuhlwilm, Martin
Hughes, David
Marques-Bonet, Tomas
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Gastrointestinal Microbiome
Disease Outbreaks
Gorilla gorilla
Hemorrhagic Fever, Ebola
Pan troglodytes
Animals
Humans
Animales
Gorilla gorilla
Humanos
Pan troglodytes
Fiebre Hemorrágica Ebola
Microbioma Gastrointestinal
Brotes de Enfermedades
Ebola
gorilla
non-invasive samples
candidate genes
topic Gastrointestinal Microbiome
Disease Outbreaks
Gorilla gorilla
Hemorrhagic Fever, Ebola
Pan troglodytes
Animals
Humans
Animales
Gorilla gorilla
Humanos
Pan troglodytes
Fiebre Hemorrágica Ebola
Microbioma Gastrointestinal
Brotes de Enfermedades
Ebola
gorilla
non-invasive samples
candidate genes
description Background Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in the resident western lowland gorilla (Gorilla gorilla gorilla) population, with a 95% mortality rate. Here, we explore the immediate genetic impact of the Ebola outbreak in the western lowland gorilla population. Results Associations with survivorship were evaluated by utilizing DNA obtained from fecal samples from 16 gorilla individuals declared missing after the outbreak (non-survivors) and 15 individuals observed before and after the epidemic (survivors). We used a target enrichment approach to capture the sequences of 123 genes previously associated with immunology and Ebola virus resistance and additionally analyzed the gut microbiome which could influence the survival after an infection. Our results indicate no changes in the population genetic diversity before and after the Ebola outbreak, and no significant differences in microbial community composition between survivors and non-survivors. However, and despite the low power for an association analysis, we do detect six nominally significant missense mutations in four genes that might be candidate variants associated with an increased chance of survival. Conclusion This study offers the first insight to the genetics of a wild great ape population before and after an Ebola outbreak using target capture experiments from fecal samples, and presents a list of candidate loci that may have facilitated their survival.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-10-11
2021
2021-10-11
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/19858
url https://hdl.handle.net/20.500.13003/19858
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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