Brain network interactions in transgender individuals with gender incongruence

Functional brain organization in transgender persons remains unclear. Our aims were to investigate global and regional connectivity differences within functional networks in transwomen and transmen with early-in-life onset gender incongruence; and to test the consistency of two available hypotheses...

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Autores: Uribe, Carme, Junqué i Plaja, Carme, 1955-, Gómez Gil, Esther, Abós, Alexandra, Mueller, Sven C., Guillamon, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183973
Acceso en línea:https://hdl.handle.net/2445/183973
Access Level:acceso abierto
Palabra clave:Imatges per ressonància magnètica
Transgèneres
Magnetic resonance imaging
Transgender people
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spelling Brain network interactions in transgender individuals with gender incongruenceUribe, CarmeJunqué i Plaja, Carme, 1955-Gómez Gil, EstherAbós, AlexandraMueller, Sven C.Guillamon, AntonioImatges per ressonància magnèticaTransgèneresMagnetic resonance imagingTransgender peopleFunctional brain organization in transgender persons remains unclear. Our aims were to investigate global and regional connectivity differences within functional networks in transwomen and transmen with early-in-life onset gender incongruence; and to test the consistency of two available hypotheses that attempted to explain gender variants: (i) a neurodevelopmental cortical hypothesis that suggests the existence of different brain phenotypes based on structural MRI data and genes polymorphisms of sex hormone receptors; (ii) a functional-based hypothesis in relation to regions involved in the own body perception. T2*-weighted images in a 3-T MRI were obtained from 29 transmen and 17 transwomen as well as 22 cisgender women and 19 cisgender men. Restingstate independent component analysis, seed-to-seed functional network and graph theory analyses were performed. Transmen, transwomen, and cisgender women had decreased connectivity compared with cisgender men in superior parietal regions, as part of the salience (SN) and the executive control (ECN) networks. Transmen also had weaker connectivity compared with cisgender men between intra-SN regions and weaker inter-network connectivity between regions of the SN, the default mode network (DMN), the ECN and the sensorimotor network. Transwomen had lower small-worldness, modularity and clustering coefficient than cisgender men. There were no differences among transmen, transwomen, and ciswomen. Together these results underline the importance of the SN interacting with DMN, ECN, and sensorimotor networks in transmen, involving regions of the entire brain with a frontal predominance. Reduced global connectivity graph-theoretical measures were a characteristic of transwomen. It is proposed that the interaction between networks is a keystone in building a gendered self. Finally, our findings suggest that both proposed hypotheses are complementary in explaining brain differences between gender variants.Elsevier B.V.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183973Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2020.116613Neuroimage, 2020, vol. 211, num. 116613https://doi.org/10.1016/j.neuroimage.2020.116613cc-by-nc-nd (c) Uribe Codesal, Carme et al., 2020https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1839732026-05-27T06:46:51Z
dc.title.none.fl_str_mv Brain network interactions in transgender individuals with gender incongruence
title Brain network interactions in transgender individuals with gender incongruence
spellingShingle Brain network interactions in transgender individuals with gender incongruence
Uribe, Carme
Imatges per ressonància magnètica
Transgèneres
Magnetic resonance imaging
Transgender people
title_short Brain network interactions in transgender individuals with gender incongruence
title_full Brain network interactions in transgender individuals with gender incongruence
title_fullStr Brain network interactions in transgender individuals with gender incongruence
title_full_unstemmed Brain network interactions in transgender individuals with gender incongruence
title_sort Brain network interactions in transgender individuals with gender incongruence
dc.creator.none.fl_str_mv Uribe, Carme
Junqué i Plaja, Carme, 1955-
Gómez Gil, Esther
Abós, Alexandra
Mueller, Sven C.
Guillamon, Antonio
author Uribe, Carme
author_facet Uribe, Carme
Junqué i Plaja, Carme, 1955-
Gómez Gil, Esther
Abós, Alexandra
Mueller, Sven C.
Guillamon, Antonio
author_role author
author2 Junqué i Plaja, Carme, 1955-
Gómez Gil, Esther
Abós, Alexandra
Mueller, Sven C.
Guillamon, Antonio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Imatges per ressonància magnètica
Transgèneres
Magnetic resonance imaging
Transgender people
topic Imatges per ressonància magnètica
Transgèneres
Magnetic resonance imaging
Transgender people
description Functional brain organization in transgender persons remains unclear. Our aims were to investigate global and regional connectivity differences within functional networks in transwomen and transmen with early-in-life onset gender incongruence; and to test the consistency of two available hypotheses that attempted to explain gender variants: (i) a neurodevelopmental cortical hypothesis that suggests the existence of different brain phenotypes based on structural MRI data and genes polymorphisms of sex hormone receptors; (ii) a functional-based hypothesis in relation to regions involved in the own body perception. T2*-weighted images in a 3-T MRI were obtained from 29 transmen and 17 transwomen as well as 22 cisgender women and 19 cisgender men. Restingstate independent component analysis, seed-to-seed functional network and graph theory analyses were performed. Transmen, transwomen, and cisgender women had decreased connectivity compared with cisgender men in superior parietal regions, as part of the salience (SN) and the executive control (ECN) networks. Transmen also had weaker connectivity compared with cisgender men between intra-SN regions and weaker inter-network connectivity between regions of the SN, the default mode network (DMN), the ECN and the sensorimotor network. Transwomen had lower small-worldness, modularity and clustering coefficient than cisgender men. There were no differences among transmen, transwomen, and ciswomen. Together these results underline the importance of the SN interacting with DMN, ECN, and sensorimotor networks in transmen, involving regions of the entire brain with a frontal predominance. Reduced global connectivity graph-theoretical measures were a characteristic of transwomen. It is proposed that the interaction between networks is a keystone in building a gendered self. Finally, our findings suggest that both proposed hypotheses are complementary in explaining brain differences between gender variants.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183973
url https://hdl.handle.net/2445/183973
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2020.116613
Neuroimage, 2020, vol. 211, num. 116613
https://doi.org/10.1016/j.neuroimage.2020.116613
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Uribe Codesal, Carme et al., 2020
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Uribe Codesal, Carme et al., 2020
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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