A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID

Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms (PSP), before...

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Detalles Bibliográficos
Autores: Utrero Rico, Alberto, Ruiz Ruigómez, María, Laguna Goya, Rocío, Arrieta Ortubay, Estíbaliz, Chivite Lacaba, Marta, González Cuadrado, Cecilia, Lalueza Blanco, Antonio, Almendro Vázquez, Patricia, Serrano, Antonio, Aguado García, José María, Lumbreras Bermejo, Carlos Juan, Paz Artal, Estela Natividad
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/4651
Acceso en línea:https://hdl.handle.net/20.500.14352/4651
Access Level:acceso abierto
Palabra clave:Long-COVID
Immunological alterations
Corticosteroids
Inmunología
2412 Inmunología
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spelling A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVIDUtrero Rico, AlbertoRuiz Ruigómez, MaríaLaguna Goya, RocíoArrieta Ortubay, EstíbalizChivite Lacaba, MartaGonzález Cuadrado, CeciliaLalueza Blanco, AntonioAlmendro Vázquez, PatriciaSerrano, AntonioAguado García, José MaríaLumbreras Bermejo, Carlos JuanPaz Artal, Estela NatividadLong-COVIDImmunological alterationsCorticosteroidsInmunología2412 InmunologíaDespite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms (PSP), before and after a 4-day prednisone course, and five post-COVID-19 patients without persistent symptoms (NSP). PSP showed a perturbed distribution of circulating mononuclear cell populations. Symptoms in PSP were accompanied by a pro-inflammatory phenotype characterized by increased conventional dendritic cells and augmented expression of antigen presentation, co-stimulation, migration, and activation markers in monocytes. The adaptive immunity compartment in PSP showed a Th1-predominance, decreased naïve and regulatory T cells, and augmentation of the PD-1 exhaustion marker. These immune alterations reverted after the corticosteroid treatment and were maintained during the 4-month follow-up, and their normalization correlated with clinical amelioration. The current work highlights an immunopathogenic basis together with a possible role for steroids in the treatment for long-COVID.MPDIUniversidad Complutense de Madrid20212021-10-2620212021-10-26journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/4651reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/46512026-06-02T12:44:21Z
dc.title.none.fl_str_mv A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
spellingShingle A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
Utrero Rico, Alberto
Long-COVID
Immunological alterations
Corticosteroids
Inmunología
2412 Inmunología
title_short A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_full A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_fullStr A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_full_unstemmed A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_sort A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
dc.creator.none.fl_str_mv Utrero Rico, Alberto
Ruiz Ruigómez, María
Laguna Goya, Rocío
Arrieta Ortubay, Estíbaliz
Chivite Lacaba, Marta
González Cuadrado, Cecilia
Lalueza Blanco, Antonio
Almendro Vázquez, Patricia
Serrano, Antonio
Aguado García, José María
Lumbreras Bermejo, Carlos Juan
Paz Artal, Estela Natividad
author Utrero Rico, Alberto
author_facet Utrero Rico, Alberto
Ruiz Ruigómez, María
Laguna Goya, Rocío
Arrieta Ortubay, Estíbaliz
Chivite Lacaba, Marta
González Cuadrado, Cecilia
Lalueza Blanco, Antonio
Almendro Vázquez, Patricia
Serrano, Antonio
Aguado García, José María
Lumbreras Bermejo, Carlos Juan
Paz Artal, Estela Natividad
author_role author
author2 Ruiz Ruigómez, María
Laguna Goya, Rocío
Arrieta Ortubay, Estíbaliz
Chivite Lacaba, Marta
González Cuadrado, Cecilia
Lalueza Blanco, Antonio
Almendro Vázquez, Patricia
Serrano, Antonio
Aguado García, José María
Lumbreras Bermejo, Carlos Juan
Paz Artal, Estela Natividad
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Long-COVID
Immunological alterations
Corticosteroids
Inmunología
2412 Inmunología
topic Long-COVID
Immunological alterations
Corticosteroids
Inmunología
2412 Inmunología
description Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms (PSP), before and after a 4-day prednisone course, and five post-COVID-19 patients without persistent symptoms (NSP). PSP showed a perturbed distribution of circulating mononuclear cell populations. Symptoms in PSP were accompanied by a pro-inflammatory phenotype characterized by increased conventional dendritic cells and augmented expression of antigen presentation, co-stimulation, migration, and activation markers in monocytes. The adaptive immunity compartment in PSP showed a Th1-predominance, decreased naïve and regulatory T cells, and augmentation of the PD-1 exhaustion marker. These immune alterations reverted after the corticosteroid treatment and were maintained during the 4-month follow-up, and their normalization correlated with clinical amelioration. The current work highlights an immunopathogenic basis together with a possible role for steroids in the treatment for long-COVID.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-10-26
2021
2021-10-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/4651
url https://hdl.handle.net/20.500.14352/4651
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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